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Fbxl16 F-box and leucine-rich repeat protein 16 [ Mus musculus (house mouse) ]

Gene ID: 214931, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxl16provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 16provided by MGI
Primary source
MGI:MGI:2448488
See related
Ensembl:ENSMUSG00000025738 AllianceGenome:MGI:2448488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scirr1
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adrenal gland; gut; male reproductive gland or organ; and nervous system. Orthologous to human FBXL16 (F-box and leucine rich repeat protein 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 168.0), frontal lobe adult (RPKM 157.2) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26027435..26040236)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25808461..25821262)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene STARR-positive B cell enhancer ABC_E7500 Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene microRNA 3082 Neighboring gene STIP1 homology and U-Box containing protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury. Liu T, et al. Exp Mol Med, 2007 Jun 30. PMID 17603280
  2. FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ, et al. Genes Dev, 2015 Oct 15. PMID 26494785, Free PMC Article
  3. F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Honarpour N, et al. Mol Cell Proteomics, 2014 Mar. PMID 24390425, Free PMC Article
  4. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Del Prete D, et al. J Biol Chem, 2016 Aug 12. PMID 27325702, Free PMC Article
  5. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells.
    Title: F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.
  2. SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord.
    Title: Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164225.2 → NP_001157697.1  F-box/LRR-repeat protein 16 isoform 1

    See identical proteins and their annotated locations for NP_001157697.1

    Status: VALIDATED

    Source sequence(s)
    AC134908, AC159277
    Consensus CDS
    CCDS50036.1
    UniProtKB/Swiss-Prot
    A2RT62
    UniProtKB/TrEMBL
    B2RPY3
    Related
    ENSMUSP00000048562.8, ENSMUST00000045692.9
    Conserved Domains (2) summary
    cd09293
    Location:201 → 413
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:220 → 243
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. NM_001379393.1 → NP_001366322.1  F-box/LRR-repeat protein 16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134908, AC159277
    UniProtKB/Swiss-Prot
    A2RT62
    UniProtKB/TrEMBL
    B2RPY3
    Conserved Domains (2) summary
    cd09293
    Location:201 → 413
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:220 → 243
    LRR_AMN1; leucine-rich repeat [structural motif]

  3. NM_001379394.1 → NP_001366323.1  F-box/LRR-repeat protein 16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134908, AC159277
    Conserved Domains (3) summary
    cd09293
    Location:297 → 509
    AMN1; Antagonist of mitotic exit network protein 1
    PHA03247
    Location:31 → 193
    PHA03247; large tegument protein UL36; Provisional
    sd00034
    Location:316 → 339
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26027435..26040236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RT62.1 GenPept UniProtKB/Swiss-Prot:A2RT62

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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