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Zfp354a zinc finger protein 354A [ Mus musculus (house mouse) ]

Gene ID: 21408, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp354aprovided by MGI
Official Full Name
zinc finger protein 354Aprovided by MGI
Primary source
MGI:MGI:103172
See related
Ensembl:ENSMUSG00000020364 AllianceGenome:MGI:103172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kid1; Tcf17; Znf354a
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and nucleolar fragmentation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and liver and biliary system. Orthologous to human ZNF354A (zinc finger protein 354A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.5), CNS E14 (RPKM 2.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 30.97 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50950052..50963626)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51059225..51072799)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29410 Neighboring gene olfactory receptor family 1 subfamily X member 2 Neighboring gene olfactory receptor family 1 subfamily X member 6 Neighboring gene RIKEN cDNA 9230009I02 gene Neighboring gene tubulin alpha-4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. Jacob AN, et al. Somat Cell Mol Genet, 1998 Mar. PMID 9919311
  2. The transcription factor, Kid-1, is highly expressed in both eye and kidney of the mouse. Brady JP, et al. Exp Eye Res, 1997 Feb. PMID 9176064
  3. Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2. Tekki-Kessaris N, et al. Gene, 1999 Nov 15. PMID 10564808
  4. Analysis of the organization and nucleotide sequence of the chromosomal gene for the beta-subunit of rat thyrotropin. Croyle ML, et al. DNA, 1986 Aug. PMID 3017658
  5. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Kim SS, et al. Proc Natl Acad Sci U S A, 1996 Dec 24. PMID 8986806, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91222

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleolus organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 354A
Names
kidney, ischemia, and developmentally-regulated protein 1
renal transcription factor Kid-1
transcription factor 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326566.1 → NP_001313495.1  zinc finger protein 354A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate start codon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 3.
    Source sequence(s)
    AK083769, AL645962, BC050843, BY137626
    Consensus CDS
    CCDS83802.1
    UniProtKB/TrEMBL
    Q5PPR4
    Related
    ENSMUSP00000104750.2, ENSMUST00000109122.8
    Conserved Domains (5) summary
    smart00349
    Location:13 → 72
    KRAB; krueppel associated box
    COG5048
    Location:209 → 566
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462 → 482
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 52
    KRAB; KRAB box
    pfam13465
    Location:334 → 359
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001347495.1 → NP_001334424.1  zinc finger protein 354A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AL645962
    Consensus CDS
    CCDS83803.1
    UniProtKB/TrEMBL
    B1ATG3
    Related
    ENSMUSP00000104747.2, ENSMUST00000109119.8
    Conserved Domains (4) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:211 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:128 → 264
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:464 → 484
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_009329.4 → NP_033355.2  zinc finger protein 354A isoform 1

    See identical proteins and their annotated locations for NP_033355.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.
    Source sequence(s)
    AK083769, AL645962, BC050843, BY137626
    Consensus CDS
    CCDS24648.1
    UniProtKB/Swiss-Prot
    Q61751, Q9QXU0
    Related
    ENSMUSP00000099827.4, ENSMUST00000102766.10
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:184 → 567
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463 → 483
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50950052..50963626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156508.1 → XP_036012401.1  zinc finger protein 354A isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:76 → 459
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355 → 375
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006532790.1 → XP_006532853.1  zinc finger protein 354A isoform X2

    See identical proteins and their annotated locations for XP_006532853.1

    UniProtKB/Swiss-Prot
    Q61751, Q9QXU0
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:184 → 567
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463 → 483
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_011248885.1 → XP_011247187.1  zinc finger protein 354A isoform X3

    See identical proteins and their annotated locations for XP_011247187.1

    Conserved Domains (4) summary
    smart00349
    Location:13 → 73
    KRAB; krueppel associated box
    COG5048
    Location:210 → 567
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:127 → 263
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:463 → 483
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036156506.1 → XP_036012399.1  zinc finger protein 354A isoform X2

    UniProtKB/Swiss-Prot
    Q61751, Q9QXU0
    Related
    ENSMUSP00000020628.6, ENSMUST00000020628.6
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:184 → 567
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463 → 483
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_011248886.1 → XP_011247188.1  zinc finger protein 354A isoform X3

    See identical proteins and their annotated locations for XP_011247188.1

    Conserved Domains (4) summary
    smart00349
    Location:13 → 73
    KRAB; krueppel associated box
    COG5048
    Location:210 → 567
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:127 → 263
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:463 → 483
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036156507.1 → XP_036012400.1  zinc finger protein 354A isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:76 → 459
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355 → 375
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_006532789.1 → XP_006532852.1  zinc finger protein 354A isoform X1

    See identical proteins and their annotated locations for XP_006532852.1

    UniProtKB/TrEMBL
    B1ATG3
    Conserved Domains (4) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:211 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:128 → 264
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:464 → 484
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61751.2 GenPept UniProtKB/Swiss-Prot:Q61751

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