Tarbp2 TARBP2, RISC loading complex RNA binding subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tarbp2provided by MGI
Official Full Name: TARBP2, RISC loading complex RNA binding subunitprovided by MGI
Primary source: MGI:MGI:103027
See related: Ensembl:ENSMUSG00000023051 AllianceGenome:MGI:103027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prbp; TRBP
Summary: Predicted to enable several functions, including RNA binding activity; protein N-terminus binding activity; and protein homodimerization activity. Predicted to contribute to pre-miRNA binding activity. Acts upstream of or within several processes, including positive regulation of muscle cell differentiation; regulation of gene expression; and spermatid development. Part of RISC complex. Is expressed in brain and early embryo. Orthologous to human TARBP2 (TARBP2 subunit of RISC loading complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 86.4), thymus adult (RPKM 26.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 57.65 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102423327..102432112)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102516077..102523676)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling.
Title: Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling.
TARBP2, but not PRKRA, functions in miRNA biogenesis of a subclass of miRNAs, and suggesting that functional redundancy between TARBP2 and PRKRA does not involve miRNA biogenesis.
Title: Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis.
TRBP is a novel transcriptional coactivator of the Notch signaling pathway, playing an important role in neural stem cell regulation during mammalian brain development
Title: TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway.
study demonstrated that Trbp participates in the regulation of muscle differentiation and regeneration
Title: Trbp Is Required for Differentiation of Myoblasts and Normal Regeneration of Skeletal Muscle.
These data indicate that the association between PKR and TRBP integrates metabolism with translational control and inflammatory signaling and plays important roles in metabolic homeostasis and disease.
Title: A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.
Trbp (Tarbp2), an RNA-binding protein, is required for normal heart function.
Title: Trbp regulates heart function through microRNA-mediated Sox6 repression.
The mammalian Dicer-partner TRBP, a Loqs-PB homolog, tunes where Dicer cleaves pre-miR-132. [TRBP]
Title: Dicer partner proteins tune the length of mature miRNAs in flies and mammals.
Results show the crystal structure of the interface between microRNA biogenesis proteins Dicer and TRBP. Mutations in this interface prevent recruitment of TRBP to Dicer.
Title: Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis.
Tarbp2 binding to TRPC4 promotes changes of cytosolic Ca(2+) and, thereby, leads to a dynamic regulation of Dicer activity, essentially at low endogenous Dicer concentrations.
Title: Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.
Binding of Dicer to TRBP is critical for RNAi function.
Title: Characterization of the TRBP domain required for dicer interaction and function in RNA interference.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tarbp2 (e-PCR), detects polymorphism
- UniSTS:479290

Tarbp2 (e-PCR), detects polymorphism
- UniSTS:144545

BB365815 (e-PCR)
- UniSTS:209149

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info
enables siRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables siRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RISC complex assembly	ISO Inferred from Sequence Orthology more info
involved_in global gene silencing by mRNA cleavage	ISO Inferred from Sequence Orthology more info
involved_in miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural precursor cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in pre-miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of regulatory ncRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of siRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of viral transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in siRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in siRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed
part_of RISC complex	ISO Inferred from Sequence Orthology more info
part_of RISC-loading complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RISC-loading complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RISC-loading complex subunit TARBP2

Names: PRM-1 RNA-binding protein; TAR (HIV) RNA binding protein 2; TAR RNA-binding protein 2; protamine-1 RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253795.2 → NP_001240724.1 RISC-loading complex subunit TARBP2 isoform 2

See identical proteins and their annotated locations for NP_001240724.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons in the 5' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminal region, compared to isoform 1.

Source sequence(s)

AC137156

Consensus CDS

CCDS57013.1

UniProtKB/TrEMBL

Q3UNH9

Related

ENSMUSP00000097744.4, ENSMUST00000100168.10

Conserved Domains (2) summary

cd10844
Location:67 → 133

DSRM_TARBP2_rpt2; second double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

cd19893
Location:200 → 271

DSRM_TARBP2_rpt3; third double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins
NM_001416318.1 → NP_001403247.1 RISC-loading complex subunit TARBP2 isoform 3

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416319.1 → NP_001403248.1 RISC-loading complex subunit TARBP2 isoform 19

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416320.1 → NP_001403249.1 RISC-loading complex subunit TARBP2 isoform 4

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416321.1 → NP_001403250.1 RISC-loading complex subunit TARBP2 isoform 5

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416322.1 → NP_001403251.1 RISC-loading complex subunit TARBP2 isoform 5

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416323.1 → NP_001403252.1 RISC-loading complex subunit TARBP2 isoform 5

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416324.1 → NP_001403253.1 RISC-loading complex subunit TARBP2 isoform 5

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416325.1 → NP_001403254.1 RISC-loading complex subunit TARBP2 isoform 6

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416326.1 → NP_001403255.1 RISC-loading complex subunit TARBP2 isoform 7

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416327.1 → NP_001403256.1 RISC-loading complex subunit TARBP2 isoform 8

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416328.1 → NP_001403257.1 RISC-loading complex subunit TARBP2 isoform 9

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416335.1 → NP_001403264.1 RISC-loading complex subunit TARBP2 isoform 10

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416336.1 → NP_001403265.1 RISC-loading complex subunit TARBP2 isoform 11

Status: VALIDATED

Source sequence(s)

AC137156

Related

ENSMUSP00000123339.2, ENSMUST00000142194.3
NM_001416337.1 → NP_001403266.1 RISC-loading complex subunit TARBP2 isoform 12

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416338.1 → NP_001403267.1 RISC-loading complex subunit TARBP2 isoform 13

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416339.1 → NP_001403268.1 RISC-loading complex subunit TARBP2 isoform 13

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416340.1 → NP_001403269.1 RISC-loading complex subunit TARBP2 isoform 14

Status: VALIDATED

Source sequence(s)

AC137156

Related

ENSMUSP00000121748.2, ENSMUST00000146756.8
NM_001416341.1 → NP_001403270.1 RISC-loading complex subunit TARBP2 isoform 15

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416342.1 → NP_001403271.1 RISC-loading complex subunit TARBP2 isoform 16

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416343.1 → NP_001403272.1 RISC-loading complex subunit TARBP2 isoform 16

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416344.1 → NP_001403273.1 RISC-loading complex subunit TARBP2 isoform 16

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416345.1 → NP_001403274.1 RISC-loading complex subunit TARBP2 isoform 16

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416346.1 → NP_001403275.1 RISC-loading complex subunit TARBP2 isoform 17

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416347.1 → NP_001403276.1 RISC-loading complex subunit TARBP2 isoform 17

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416348.1 → NP_001403277.1 RISC-loading complex subunit TARBP2 isoform 18

Status: VALIDATED

Source sequence(s)

AC137156
NM_001416349.1 → NP_001403278.1 RISC-loading complex subunit TARBP2 isoform 17

Status: VALIDATED

Source sequence(s)

AC137156
NM_009319.4 → NP_033345.2 RISC-loading complex subunit TARBP2 isoform 1

See identical proteins and their annotated locations for NP_033345.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC137156

Consensus CDS

CCDS27886.1

UniProtKB/Swiss-Prot

P97473, Q99M41

UniProtKB/TrEMBL

A0AA74KTE6

Related

ENSMUSP00000023813.3, ENSMUST00000023813.9

Conserved Domains (3) summary

cd10844
Location:158 → 224

DSRM_TARBP2_rpt2; second double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

cd19890
Location:27 → 98

DSRM_TARBP2_rpt1; first double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

cd19893
Location:291 → 362

DSRM_TARBP2_rpt3; third double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

RNA

NR_183770.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC137156
NR_183771.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC137156

Related

ENSMUST00000131184.8
NR_183772.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC137156

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

102423327..102432112

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248453.2 → XP_030104313.1 RISC-loading complex subunit TARBP2 isoform X1

UniProtKB/Swiss-Prot

P97473, Q99M41

UniProtKB/TrEMBL

A0AA74KTE6

Conserved Domains (3) summary

cd10844
Location:158 → 224

DSRM_TARBP2_rpt2; second double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

cd19890
Location:27 → 98

DSRM_TARBP2_rpt1; first double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

cd19893
Location:291 → 362

DSRM_TARBP2_rpt3; third double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins
XM_036159303.1 → XP_036015196.1 RISC-loading complex subunit TARBP2 isoform X6

Conserved Domains (2) summary

cd19893
Location:114 → 185

DSRM_TARBP2_rpt3; third double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

cl00054
Location:2 → 47

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_036159304.1 → XP_036015197.1 RISC-loading complex subunit TARBP2 isoform X6

Conserved Domains (2) summary

cd19893
Location:114 → 185

DSRM_TARBP2_rpt3; third double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

cl00054
Location:2 → 47

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_036159300.1 → XP_036015193.1 RISC-loading complex subunit TARBP2 isoform X5

Conserved Domains (2) summary

cd10844
Location:15 → 81

DSRM_TARBP2_rpt2; second double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins

cd19893
Location:148 → 219

DSRM_TARBP2_rpt3; third double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins