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Rbbp5 retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit [ Mus musculus (house mouse) ]

Gene ID: 213464, updated on 5-Mar-2024

Summary

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Official Symbol
Rbbp5provided by MGI
Official Full Name
retinoblastoma binding protein 5, histone lysine methyltransferase complex subunitprovided by MGI
Primary source
MGI:MGI:1918367
See related
Ensembl:ENSMUSG00000026439 AllianceGenome:MGI:1918367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330016J05; 4933411J24Rik
Summary
Predicted to enable methylated histone binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to histone methyltransferase activity (H3-K4 specific). Acts upstream of or within histone H3-K4 methylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Is expressed in cerebral cortex and genitourinary system. Orthologous to human RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.4), cerebellum adult (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rbbp5 in Genome Data Viewer
Location:
1 E4; 1 57.24 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132405087..132436382)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132477348..132505665)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57562 Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene RIKEN cDNA 6030442K20 gene Neighboring gene STARR-seq mESC enhancer starr_02257 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:134373585-134373776 Neighboring gene transmembrane protein 81 Neighboring gene contactin 2 Neighboring gene predicted gene, 51646

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Zhang P, et al. Genes Dev, 2015 Jan 15. PMID 25593305, Free PMC Article
  2. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Jiang H, et al. Cell, 2011 Feb 18. PMID 21335234, Free PMC Article
  3. Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1. Odho Z, et al. J Biol Chem, 2010 Oct 22. PMID 20716525, Free PMC Article
  4. Evolving Catalytic Properties of the MLL Family SET Domain. Zhang Y, et al. Structure, 2015 Oct 6. PMID 26320581, Free PMC Article
  5. Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Ang YS, et al. Cell, 2011 Apr 15. PMID 21477851, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a phosphorylation switch on RbBP5 stimulates WRAD complex formation and significantly increases KMT2 (lysine [K] methyltransferase 2) enzyme methylation rates
    Title: A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.
  2. Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1.
    Title: Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1/2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
retinoblastoma-binding protein 5
Names
RBBP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357486.1 → NP_001344415.1  retinoblastoma-binding protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107846
    UniProtKB/TrEMBL
    A0A0R4J2B6
    Conserved Domains (3) summary
    PTZ00441
    Location:340 → 493
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:29 → 64
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:30 → 322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001357487.1 → NP_001344416.1  retinoblastoma-binding protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107846
    Consensus CDS
    CCDS87875.1
    UniProtKB/TrEMBL
    A0A087WST2
    Related
    ENSMUSP00000027700.10, ENSMUST00000027700.15
    Conserved Domains (3) summary
    COG2319
    Location:10 → 194
    WD40; WD40 repeat [General function prediction only]
    PTZ00441
    Location:213 → 366
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:75 → 120
    7WD40; WD40 repeat [structural motif]

  3. NM_172517.2 → NP_766105.2  retinoblastoma-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_766105.2

    Status: VALIDATED

    Source sequence(s)
    AC107846, AK049247, BY193756, CV562303
    Consensus CDS
    CCDS15286.1
    UniProtKB/Swiss-Prot
    Q3TBL4, Q3U3G1, Q6PAP0, Q6PFC2, Q8BX09
    UniProtKB/TrEMBL
    A0A0R4J2B6
    Related
    ENSMUSP00000141003.2, ENSMUST00000190997.7
    Conserved Domains (3) summary
    PTZ00441
    Location:340 → 498
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:29 → 64
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:30 → 322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    132405087..132436382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529358.4 → XP_006529421.1  retinoblastoma-binding protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J2B6
    Conserved Domains (3) summary
    PTZ00441
    Location:301 → 459
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:30 → 67
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:34 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_030252808.2 → XP_030108668.1  retinoblastoma-binding protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A0R4J2B6
    Conserved Domains (3) summary
    PTZ00441
    Location:301 → 454
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:30 → 67
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:34 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_036163427.1 → XP_036019320.1  retinoblastoma-binding protein 5 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:9 → 98
    WD40; WD40 repeat [General function prediction only]
    PTZ00441
    Location:99 → 257
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:16 → 50
    7WD40; WD40 repeat [structural motif]

  4. XM_036163429.1 → XP_036019322.1  retinoblastoma-binding protein 5 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:9 → 98
    WD40; WD40 repeat [General function prediction only]
    PTZ00441
    Location:99 → 257
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:16 → 50
    7WD40; WD40 repeat [structural motif]

  5. XM_036163434.1 → XP_036019327.1  retinoblastoma-binding protein 5 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:9 → 80
    WD40; WD40 repeat [General function prediction only]
    PTZ00441
    Location:99 → 252
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:16 → 50
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_003954377.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX09.2 GenPept UniProtKB/Swiss-Prot:Q8BX09

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