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Stk16 serine/threonine kinase 16 [ Mus musculus (house mouse) ]

Gene ID: 20872, updated on 11-Apr-2024

Summary

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Official Symbol
Stk16provided by MGI
Official Full Name
serine/threonine kinase 16provided by MGI
Primary source
MGI:MGI:1313271
See related
Ensembl:ENSMUSG00000026201 AllianceGenome:MGI:1313271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EDPK; Krct; MPSK; PKL12; TSF-1
Summary
Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in Golgi apparatus and Golgi-associated vesicle. Is expressed in several structures, including central nervous system; genitourinary system; gut; neural retina; and respiratory system. Orthologous to human STK16 (serine/threonine kinase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 26.8), kidney adult (RPKM 26.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C4; 1 38.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75187463..75192250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75210819..75215606)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321 Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase, beta 1-like Neighboring gene STARR-positive B cell enhancer ABC_E3282 Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene tubulin, alpha 4A Neighboring gene STARR-seq mESC enhancer starr_01353 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a novel protein serine/threonine kinase highly expressed in mouse embryo. Kurioka K, et al. Biochim Biophys Acta, 1998 Dec 22. PMID 9878782
  2. Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. Berson AE, et al. Biochem Biophys Res Commun, 1999 Jun 16. PMID 10364453
  3. Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation. Guinea B, et al. Exp Cell Res, 2006 Jan 15. PMID 16310770
  4. Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling. Ligos JM, et al. J Biol Chem, 2002 Feb 22. PMID 11741987
  5. Mammary gland development, reproductive history, and breast cancer risk. Chodosh LA, et al. Cancer Res, 1999 Apr 1. PMID 10197594

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 16
Names
TGF-beta-stimulated factor 1
embryo-derived protein kinase
kinase related to cerevisiae and thaliana
myristoylated and palmitoylated serine/threonine-protein kinase
tyrosine-protein kinase STK16
NP_001264921.1
NP_035624.3
XP_006496524.1
XP_006496525.1
XP_030108374.1
XP_030108376.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277992.1 → NP_001264921.1  serine/threonine-protein kinase 16

    See identical proteins and their annotated locations for NP_001264921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK030404, BY198855, CX200029
    Consensus CDS
    CCDS15067.1
    UniProtKB/Swiss-Prot
    O88697, Q3UEG5, Q9JMJ0, Q9JMJ1, Q9QX00
    UniProtKB/TrEMBL
    Q8BSV9
    Conserved Domains (1) summary
    cd13986
    Location:19 → 295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

  2. NM_011494.5 → NP_035624.3  serine/threonine-protein kinase 16

    See identical proteins and their annotated locations for NP_035624.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK030404, AK149539, BY237826
    Consensus CDS
    CCDS15067.1
    UniProtKB/Swiss-Prot
    O88697, Q3UEG5, Q9JMJ0, Q9JMJ1, Q9QX00
    UniProtKB/TrEMBL
    Q8BSV9
    Related
    ENSMUSP00000027401.5, ENSMUST00000027401.11
    Conserved Domains (1) summary
    cd13986
    Location:19 → 295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

RNA

  1. NR_102731.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA183397, AC166150, AK030404, BY237826

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75187463..75192250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496462.2 → XP_006496525.1  serine/threonine-protein kinase 16 isoform X2

    See identical proteins and their annotated locations for XP_006496525.1

    UniProtKB/TrEMBL
    Q8BSV9
    Conserved Domains (1) summary
    cd13986
    Location:19 → 263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

  2. XM_006496461.3 → XP_006496524.1  serine/threonine-protein kinase 16 isoform X1

    See identical proteins and their annotated locations for XP_006496524.1

    UniProtKB/Swiss-Prot
    O88697, Q3UEG5, Q9JMJ0, Q9JMJ1, Q9QX00
    UniProtKB/TrEMBL
    Q8BSV9
    Conserved Domains (1) summary
    cd13986
    Location:19 → 295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

  3. XM_030252516.2 → XP_030108376.1  serine/threonine-protein kinase 16 isoform X2

    UniProtKB/TrEMBL
    Q8BSV9
    Conserved Domains (1) summary
    cd13986
    Location:19 → 263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

  4. XM_030252514.2 → XP_030108374.1  serine/threonine-protein kinase 16 isoform X2

    UniProtKB/TrEMBL
    Q8BSV9
    Conserved Domains (1) summary
    cd13986
    Location:19 → 263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

RNA

  1. XR_004941329.1 RNA Sequence

  2. XR_004941328.1 RNA Sequence

    Related
    ENSMUST00000191108.7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88697.3 GenPept UniProtKB/Swiss-Prot:O88697

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