Stk11 serine/threonine kinase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk11provided by MGI
Official Full Name: serine/threonine kinase 11provided by MGI
Primary source: MGI:MGI:1341870
See related: Ensembl:ENSMUSG00000003068 AllianceGenome:MGI:1341870
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lkb1; Par-4
Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
Expression: Ubiquitous expression in thymus adult (RPKM 32.5), testis adult (RPKM 30.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79951602..79966513)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80115767..80130679)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LKB1 delays atherosclerosis by inhibiting phenotypic transformation of vascular smooth muscle cells.
Title: LKB1 delays atherosclerosis by inhibiting phenotypic transformation of vascular smooth muscle cells.
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.
Title: MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.
Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6.
Title: Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6.
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.
Title: STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.
Title: MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.
AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
Title: AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model.
Title: LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model.
LKB1 Positively Regulates Dendritic Cell-induced T Cell Immunity and Suppresses Tumor Development.
Title: LKB1 Positively Regulates Dendritic Cell-induced T Cell Immunity and Suppresses Tumor Development.
Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.
Title: Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
Title: LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (246)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (20) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stk11 (e-PCR), detects polymorphism
- UniSTS:158764

MARC_3363-3364:991937109:1 (e-PCR)
- UniSTS:231020

PMC124396P1 (e-PCR)
- UniSTS:270467

RH125172 (e-PCR)
- UniSTS:161994

RH125759 (e-PCR)
- UniSTS:162511

Stk11 (e-PCR), detects polymorphism
- UniSTS:546517

Stk11 (e-PCR), detects polymorphism
- UniSTS:546518

Stk11 (e-PCR), detects polymorphism
- UniSTS:546519

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables LRR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect G1 to G0 transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Golgi localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in anoikis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vesicle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipid	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Z disc	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of intracellular protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of serine/threonine protein kinase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase STK11

Names: liver kinase B1 homolog; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1

NP_001288782.1

EC 2.7.11.1

NP_001288783.1

EC 2.7.11.1

NP_035622.1

EC 2.7.11.1

XP_006513502.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301853.2 → NP_001288782.1 serine/threonine-protein kinase STK11 isoform S

See identical proteins and their annotated locations for NP_001288782.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (S, see PMID:18774945) has a distinct C-terminus and is shorter than isoform L.

Source sequence(s)

AC159999

Consensus CDS

CCDS78854.1

UniProtKB/Swiss-Prot

Q9WTK7

Related

ENSMUSP00000114195.2, ENSMUST00000144883.8

Conserved Domains (2) summary

smart00220
Location:49 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:55 → 309

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_001301854.2 → NP_001288783.1 serine/threonine-protein kinase STK11 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform L.

Source sequence(s)

AC159999

UniProtKB/TrEMBL

E9Q811

Related

ENSMUSP00000101009.2, ENSMUST00000105370.8

Conserved Domains (2) summary

smart00220
Location:1 → 185

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:1 → 185

PKc_like; Protein Kinases, catalytic domain
NM_011492.5 → NP_035622.1 serine/threonine-protein kinase STK11 isoform L

See identical proteins and their annotated locations for NP_035622.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (L, see PMID:18774945).

Source sequence(s)

AC159999

Consensus CDS

CCDS35974.1

UniProtKB/Swiss-Prot

A0A2L1DGD8, B3VBP0, Q3TAE0, Q9WTK7

Related

ENSMUSP00000003152.8, ENSMUST00000003152.14

Conserved Domains (2) summary

smart00220
Location:49 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:55 → 309

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

RNA

NR_126043.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in the variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC159999

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79951602..79966513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513439.5 → XP_006513502.1 serine/threonine-protein kinase STK11 isoform X1

UniProtKB/TrEMBL

Q9R0P1

Conserved Domains (1) summary

cd14119
Location:79 → 291

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1