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Mterf1b mitochondrial transcription termination factor 1b [ Mus musculus (house mouse) ]

Gene ID: 208595, updated on 21-May-2024

Summary

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Official Symbol
Mterf1bprovided by MGI
Official Full Name
mitochondrial transcription termination factor 1bprovided by MGI
Primary source
MGI:MGI:3704243
See related
Ensembl:ENSMUSG00000053178 AllianceGenome:MGI:3704243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm9897
Summary
Enables sequence-specific DNA binding activity. Acts upstream of or within transcription initiation from mitochondrial promoter. Located in mitochondrion. Orthologous to human MTERF1 (mitochondrial transcription termination factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 1.7), liver E14 (RPKM 1.5) and 24 other tissues See more
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Genomic context

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See Mterf1b in Genome Data Viewer
Location:
5 A1; 5 2.34 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (4242329..4247652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (4192328..4197651)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E2737 Neighboring gene STARR-seq mESC enhancer starr_12323 Neighboring gene predicted gene, 40260 Neighboring gene cytochrome P450, family 51 Neighboring gene STARR-seq mESC enhancer starr_12324 Neighboring gene STARR-positive B cell enhancer ABC_E3561 Neighboring gene STARR-seq mESC enhancer starr_12326 Neighboring gene STARR-seq mESC enhancer starr_12327 Neighboring gene STARR-seq mESC enhancer starr_12328 Neighboring gene predicted gene, 40261 Neighboring gene STARR-seq mESC enhancer starr_12329 Neighboring gene STARR-seq mESC enhancer starr_12330 Neighboring gene STARR-seq mESC enhancer starr_12331 Neighboring gene STARR-seq mESC enhancer starr_12332 Neighboring gene STARR-seq mESC enhancer starr_12333 Neighboring gene STARR-seq mESC enhancer starr_12334 Neighboring gene predicted gene, 54299

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Terzioglu M, et al. Cell Metab, 2013 Apr 2. PMID 23562081
  2. Cloning and characterization of mouse mTERF encoding a mitochondrial transcriptional termination factor. Li X, et al. Biochem Biophys Res Commun, 2005 Jan 14. PMID 15582606
  3. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA geometric change ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA-templated transcription termination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in termination of mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transcription initiation at mitochondrial promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription termination factor 1b, mitochondrial
Names
transcription termination factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042670.2 → NP_001036135.3  transcription termination factor 1b, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AC068609
    Consensus CDS
    CCDS39004.2
    UniProtKB/Swiss-Prot
    B9EJ57, L7N482
    Related
    ENSMUSP00000135408.3, ENSMUST00000177258.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    4242329..4247652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503569.4 → XP_006503632.1  transcription termination factor 1b, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006503632.1

    UniProtKB/TrEMBL
    A0A096P6K7
    Conserved Domains (1) summary
    pfam02536
    Location:60 → 373
    mTERF
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9EJ57.1 GenPept UniProtKB/Swiss-Prot:B9EJ57

Gene LinkOut

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