Stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stamprovided by MGI
Official Full Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1provided by MGI
Primary source: MGI:MGI:1329014
See related: Ensembl:ENSMUSG00000026718 AllianceGenome:MGI:1329014
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: STAM1
Summary: Predicted to enable ubiquitin-like protein ligase binding activity. Predicted to be involved in positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; and regulation of extracellular exosome assembly. Predicted to act upstream of or within protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ESCRT-0 complex. Orthologous to human STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 14.5), whole brain E14.5 (RPKM 13.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A2; 2 10.36 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (14078912..14152351)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (14073962..14148338)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the motor neuron-specific ISL1-LHX3 complex directly transactivates the Stam1 gene.
Title: Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.
ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
Title: ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
Title: Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.
Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins
Title: Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2.
plays important role in the mammalian endosomal/vacuolar protein sorting pathway
Title: Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC139881P1 (e-PCR)
- UniSTS:270901

NoName (e-PCR)
- UniSTS:234330

BE690800 (e-PCR)
- UniSTS:207289

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of exosomal secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of extracellular exosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ESCRT-0 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT-0 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal transducing adapter molecule 1

Names: STAM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356337.2 → NP_001343266.1 signal transducing adapter molecule 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoforom 1.

Source sequence(s)

AL844560, AL845434

UniProtKB/TrEMBL

Q3UMC8

Conserved Domains (2) summary

cd11964
Location:163 → 217

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

cl02544
Location:1 → 92

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
NM_001421093.1 → NP_001408022.1 signal transducing adapter molecule 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL844560, AL845434
NM_001421094.1 → NP_001408023.1 signal transducing adapter molecule 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL844560, AL845434
NM_001421095.1 → NP_001408024.1 signal transducing adapter molecule 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL844560, AL845434
NM_001421096.1 → NP_001408025.1 signal transducing adapter molecule 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL844560, AL845434
NM_001421097.1 → NP_001408026.1 signal transducing adapter molecule 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL844560, AL845434

UniProtKB/TrEMBL

Q3UGN9
NM_001421098.1 → NP_001408027.1 signal transducing adapter molecule 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL845434
NM_001421099.1 → NP_001408028.1 signal transducing adapter molecule 1 isoform 9

Status: VALIDATED

Source sequence(s)

AL844560, AL845434
NM_001421100.1 → NP_001408029.1 signal transducing adapter molecule 1 isoform 10

Status: VALIDATED

Source sequence(s)

AL844560, AL845434
NM_001421101.1 → NP_001408030.1 signal transducing adapter molecule 1 isoform 11

Status: VALIDATED

Source sequence(s)

AL844560, AL845434
NM_011484.4 → NP_035614.1 signal transducing adapter molecule 1 isoform 1

See identical proteins and their annotated locations for NP_035614.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AL844560, AL845434

Consensus CDS

CCDS15698.1

UniProtKB/Swiss-Prot

P70297

UniProtKB/TrEMBL

Q3TQ49, Q3UMC8

Related

ENSMUSP00000100025.5, ENSMUST00000102960.11

Conserved Domains (3) summary

cd11964
Location:213 → 267

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

cd03568
Location:9 → 142

VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

pfam03127
Location:306 → 377

GAT; GAT domain

RNA

NR_185242.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL844560, AL845434
NR_185243.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL844560, AL845434