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Exog exo/endonuclease G [ Mus musculus (house mouse) ]

Gene ID: 208194, updated on 5-Mar-2024

Summary

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Official Symbol
Exogprovided by MGI
Official Full Name
exo/endonuclease Gprovided by MGI
Primary source
MGI:MGI:2143333
See related
Ensembl:ENSMUSG00000042787 AllianceGenome:MGI:2143333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Engl; Engla; Englb; ENGL-B; ENGL-a; Endogl1; Endogl2
Summary
Predicted to enable 5'-3' exonuclease activity; endoribonuclease activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Located in mitochondrion. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.0), whole brain E14.5 (RPKM 5.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Exog in Genome Data Viewer
Location:
9 F3; 9 71.33 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119274026..119294584)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119444925..119465518)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53515 Neighboring gene activin receptor IIB Neighboring gene STARR-positive B cell enhancer mm9_chr9:119353850-119354151 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119374205-119374506 Neighboring gene STARR-seq mESC enhancer starr_25473 Neighboring gene sodium channel, voltage-gated, type V, alpha Neighboring gene STARR-seq mESC enhancer starr_25474 Neighboring gene sodium channel, voltage-gated, type X, alpha Neighboring gene STARR-seq mESC enhancer starr_25475

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Szczesny B, et al. Nucleic Acids Res, 2014 Dec 1. PMID 25378300, Free PMC Article
  2. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article
  3. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
nuclease EXOG, mitochondrial
Names
endo G-like 1
endo/exonuclease (5'-3'), endonuclease G-like
endonuclease G-like 1
NP_001397518.1
NP_001397519.1
NP_001397520.1
NP_001397521.1
NP_001397522.1
NP_766044.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410589.1 → NP_001397518.1  nuclease EXOG, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052

  2. NM_001410590.1 → NP_001397519.1  nuclease EXOG, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052

  3. NM_001410591.1 → NP_001397520.1  nuclease EXOG, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052

  4. NM_001410592.1 → NP_001397521.1  nuclease EXOG, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052

  5. NM_001410593.1 → NP_001397522.1  nuclease EXOG, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052

  6. NM_172456.4 → NP_766044.1  nuclease EXOG, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_766044.1

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052
    Consensus CDS
    CCDS23616.1
    UniProtKB/Swiss-Prot
    Q3UFL2, Q8C163
    Related
    ENSMUSP00000035094.7, ENSMUST00000035094.14
    Conserved Domains (1) summary
    smart00477
    Location:77 → 287
    NUC; DNA/RNA non-specific endonuclease

RNA

  1. NR_177092.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052

  2. NR_177093.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052

  3. NR_177094.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121922, AC166052

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119274026..119294584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001172136.1: Suppressed sequence

    Description
    NM_001172136.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C163.1 GenPept UniProtKB/Swiss-Prot:Q8C163

Gene LinkOut

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