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Phldb2 pleckstrin homology like domain, family B, member 2 [ Mus musculus (house mouse) ]

Gene ID: 208177, updated on 5-Mar-2024

Summary

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Official Symbol
Phldb2provided by MGI
Official Full Name
pleckstrin homology like domain, family B, member 2provided by MGI
Primary source
MGI:MGI:2444981
See related
Ensembl:ENSMUSG00000033149 AllianceGenome:MGI:2444981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LL5b; LL5beta; C820004H04Rik
Summary
Predicted to be involved in several processes, including negative regulation of focal adhesion assembly; regulation of cytoskeleton organization; and regulation of embryonic development. Predicted to be located in several cellular components, including cell leading edge; cytosol; and intermediate filament cytoskeleton. Predicted to be active in basal cortex. Predicted to colocalize with focal adhesion. Orthologous to human PHLDB2 (pleckstrin homology like domain family B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 19.0), limb E14.5 (RPKM 13.1) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 30.08 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45566593..45773961, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45746230..45953598, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40920 Neighboring gene transgelin 3 Neighboring gene STARR-seq mESC enhancer starr_40921 Neighboring gene abhydrolase domain containing 10 Neighboring gene STARR-seq mESC enhancer starr_40922 Neighboring gene predicted gene 15638 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46006394-46006690 Neighboring gene STARR-positive B cell enhancer ABC_E4173 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46011002-46011185 Neighboring gene predicted gene, 24754

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner. Xie MJ, et al. Neurosci Res, 2022 Dec. PMID 36162735
  2. PIP(3)-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover. Xie MJ, et al. Sci Rep, 2019 Mar 13. PMID 30867511, Free PMC Article
  3. CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles. Basu S, et al. Mol Biol Cell, 2015 Mar 1. PMID 25589673, Free PMC Article
  4. BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex. Hiepen C, et al. BMC Biol, 2014 May 30. PMID 24885555, Free PMC Article
  5. LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction. Kishi M, et al. J Cell Biol, 2005 Apr 25. PMID 15851520, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner.
    Title: Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner.
  2. PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
    Title: PIP(3)-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
  3. A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
    Title: CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
  4. These results provide evidence for an important contribution of the BMP2-PI3K (p55gamma/p110alpha)- PIP3-LL5beta signalling axis in mesenchymal progenitor cell chemotaxis.
    Title: BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gastrulation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basal cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology-like domain family B member 2
Names
protein LL5-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252442.1 → NP_001239371.1  pleckstrin homology-like domain family B member 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK087133, AK165251, BB851780, BC050915, BY442240
    Consensus CDS
    CCDS57031.1
    UniProtKB/TrEMBL
    D3Z069
    Related
    ENSMUSP00000075672.6, ENSMUST00000076333.12
    Conserved Domains (4) summary
    cd14673
    Location:1191 → 1295
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:1194 → 1290
    PH; PH domain
    cl02488
    Location:597 → 786
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl19107
    Location:1085 → 1155
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. NM_001357078.1 → NP_001344007.1  pleckstrin homology-like domain family B member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC164979, AC166572
    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (4) summary
    TIGR00618
    Location:523 → 1070
    sbcc; exonuclease SbcC
    COG1196
    Location:575 → 767
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1095 → 1199
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:987 → 1054
    DUF5401; Family of unknown function (DUF5401)

  3. NM_153412.4 → NP_700461.2  pleckstrin homology-like domain family B member 2 isoform 2

    See identical proteins and their annotated locations for NP_700461.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC164979, AC166572
    Consensus CDS
    CCDS28202.1
    UniProtKB/Swiss-Prot
    Q3TNI3, Q80Y16, Q8BKV3, Q8K1N2
    UniProtKB/TrEMBL
    D3Z069
    Related
    ENSMUSP00000046496.7, ENSMUST00000036355.13
    Conserved Domains (4) summary
    cd14673
    Location:1138 → 1242
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:1141 → 1237
    PH; PH domain
    cl02488
    Location:597 → 786
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl19107
    Location:1032 → 1102
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45566593..45773961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159845.1 → XP_036015738.1  pleckstrin homology-like domain family B member 2 isoform X20

    UniProtKB/TrEMBL
    F6QU68, Q8BZE3
    Related
    ENSMUSP00000119718.2, ENSMUST00000131003.8
    Conserved Domains (3) summary
    cd14673
    Location:507 → 611
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    TIGR02168
    Location:30 → 180
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17380
    Location:399 → 466
    DUF5401; Family of unknown function (DUF5401)

  2. XM_006521926.4 → XP_006521989.1  pleckstrin homology-like domain family B member 2 isoform X7

    See identical proteins and their annotated locations for XP_006521989.1

    UniProtKB/TrEMBL
    D3Z069
    Related
    ENSMUSP00000123284.2, ENSMUST00000134802.8
    Conserved Domains (3) summary
    COG1196
    Location:584 → 847
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1183 → 1287
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam02463
    Location:626 → 1168
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_006521921.4 → XP_006521984.1  pleckstrin homology-like domain family B member 2 isoform X2

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:580 → 843
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1240 → 1344
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00769
    Location:1132 → 1205
    ERM; Ezrin/radixin/moesin family

  4. XM_030249020.1 → XP_030104880.1  pleckstrin homology-like domain family B member 2 isoform X15

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:620 → 841
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1092 → 1196
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:987 → 1055
    DUF5401; Family of unknown function (DUF5401)

  5. XM_006521928.4 → XP_006521991.1  pleckstrin homology-like domain family B member 2 isoform X10

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    TIGR00618
    Location:568 → 1115
    sbcc; exonuclease SbcC
    COG1196
    Location:620 → 812
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1140 → 1244
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

  6. XM_006521923.4 → XP_006521986.1  pleckstrin homology-like domain family B member 2 isoform X5

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:620 → 812
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1201 → 1305
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00769
    Location:1093 → 1166
    ERM; Ezrin/radixin/moesin family

  7. XM_036159842.1 → XP_036015735.1  pleckstrin homology-like domain family B member 2 isoform X17

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:584 → 847
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1088 → 1192
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    TIGR02168
    Location:712 → 1053
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_006521929.4 → XP_006521992.1  pleckstrin homology-like domain family B member 2 isoform X11

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG0419
    Location:628 → 1094
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:584 → 847
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1135 → 1239
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

  9. XM_006521927.4 → XP_006521990.1  pleckstrin homology-like domain family B member 2 isoform X8

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG0419
    Location:628 → 1119
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:584 → 847
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1160 → 1264
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

  10. XM_011245859.3 → XP_011244161.1  pleckstrin homology-like domain family B member 2 isoform X3

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:584 → 847
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1221 → 1325
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam15921
    Location:642 → 1172
    CCDC158; Coiled-coil domain-containing protein 158

  11. XM_006521920.4 → XP_006521983.1  pleckstrin homology-like domain family B member 2 isoform X1

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:584 → 847
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1244 → 1348
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:1139 → 1207
    DUF5401; Family of unknown function (DUF5401)

  12. XM_030249019.1 → XP_030104879.1  pleckstrin homology-like domain family B member 2 isoform X2

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:580 → 843
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1240 → 1344
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00769
    Location:1132 → 1205
    ERM; Ezrin/radixin/moesin family

  13. XM_006521925.5 → XP_006521988.1  pleckstrin homology-like domain family B member 2 isoform X6

    See identical proteins and their annotated locations for XP_006521988.1

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:539 → 802
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1199 → 1303
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:1094 → 1162
    DUF5401; Family of unknown function (DUF5401)

  14. XM_006521922.5 → XP_006521985.1  pleckstrin homology-like domain family B member 2 isoform X4

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:550 → 813
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1210 → 1314
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:1105 → 1173
    DUF5401; Family of unknown function (DUF5401)

  15. XM_036159837.1 → XP_036015730.1  pleckstrin homology-like domain family B member 2 isoform X9

    Conserved Domains (3) summary
    COG1196
    Location:575 → 767
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1156 → 1260
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:1048 → 1115
    DUF5401; Family of unknown function (DUF5401)

  16. XM_006521924.5 → XP_006521987.1  pleckstrin homology-like domain family B member 2 isoform X6

    See identical proteins and their annotated locations for XP_006521987.1

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:539 → 802
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1199 → 1303
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:1094 → 1162
    DUF5401; Family of unknown function (DUF5401)

  17. XM_036159839.1 → XP_036015732.1  pleckstrin homology-like domain family B member 2 isoform X13

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    TIGR00618
    Location:534 → 1081
    sbcc; exonuclease SbcC
    COG1196
    Location:586 → 778
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1106 → 1210
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

  18. XM_036159843.1 → XP_036015736.1  pleckstrin homology-like domain family B member 2 isoform X18

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:575 → 796
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1047 → 1151
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:939 → 1006
    DUF5401; Family of unknown function (DUF5401)

  19. XM_036159840.1 → XP_036015733.1  pleckstrin homology-like domain family B member 2 isoform X14

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (4) summary
    TIGR00618
    Location:523 → 1070
    sbcc; exonuclease SbcC
    COG1196
    Location:575 → 767
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1095 → 1199
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:987 → 1054
    DUF5401; Family of unknown function (DUF5401)

  20. XM_036159841.1 → XP_036015734.1  pleckstrin homology-like domain family B member 2 isoform X16

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:539 → 802
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1090 → 1194
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:982 → 1049
    DUF5401; Family of unknown function (DUF5401)

  21. XM_036159838.1 → XP_036015731.1  pleckstrin homology-like domain family B member 2 isoform X12

    UniProtKB/TrEMBL
    D3Z069
    Conserved Domains (3) summary
    COG1196
    Location:539 → 802
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14673
    Location:1115 → 1219
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam17380
    Location:1007 → 1074
    DUF5401; Family of unknown function (DUF5401)

  22. XM_036159844.1 → XP_036015737.1  pleckstrin homology-like domain family B member 2 isoform X19

    Conserved Domains (3) summary
    cd14673
    Location:568 → 672
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    TIGR02168
    Location:30 → 180
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17380
    Location:460 → 527
    DUF5401; Family of unknown function (DUF5401)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1N2.2 GenPept UniProtKB/Swiss-Prot:Q8K1N2

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