Slc22a19 solute carrier family 22 (organic anion transporter), member 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a19provided by MGI
Official Full Name: solute carrier family 22 (organic anion transporter), member 19provided by MGI
Primary source: MGI:MGI:2442751
See related: Ensembl:ENSMUSG00000024757 AllianceGenome:MGI:2442751
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oat5; OAT-5; Slc22a9; D630043A20Rik
Summary: Enables organic anion transmembrane transporter activity and toxin transmembrane transporter activity. Acts upstream of or within organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in metanephros. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney adult (RPKM 62.4) See more
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Genomic context

Location:: 19 A; 19 5.34 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (7650440..7688675, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7673075..7711310, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

renal expression of Oat5 in rats (and mice) exhibits zonal and sex differences
Title: Renal expression of organic anion transporter Oat5 in rats and mice exhibits the female-dominant sex differences.
mOAT5 has a role in excretion or reabsorption of steroid sulfates in the kidney
Title: Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter.
Highly expressed in kidney. Motive forces behind Oat5 function, which provide insight into its membrane localization, need to be further resolved.
Title: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney.
mOATLP1 appears to be a novel candidate for an organic anion transporter isoform identified in the kidney.
Title: Identification of a novel murine organic anion transporter like protein 1 (OATLP1) expressed in the kidney.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables short-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables toxin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within organic anion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 19

Names: organic anion transporter 5; solute carrier family 22 (organic anion transporter), member 9; solute carrier family 22 (organic cation transporter), member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144785.2 → NP_659034.1 solute carrier family 22 member 19

See identical proteins and their annotated locations for NP_659034.1

Status: VALIDATED

Source sequence(s)

AC109225, AC130693

Consensus CDS

CCDS29532.1

UniProtKB/Swiss-Prot

Q6A4K9, Q8VCA0

Related

ENSMUSP00000025666.8, ENSMUST00000025666.8

Conserved Domains (1) summary

cl26863
Location:11 → 525

Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

7650440..7688675 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526814.3 → XP_006526877.1 solute carrier family 22 member 19 isoform X1

Conserved Domains (1) summary

cl28910
Location:109 → 495

MFS; Major Facilitator Superfamily
XM_006526815.1 → XP_006526878.1 solute carrier family 22 member 19 isoform X2

Conserved Domains (1) summary

cl28910
Location:109 → 429

MFS; Major Facilitator Superfamily