Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina3gprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 3Gprovided by MGI
Primary source: MGI:MGI:105046
See related: Ensembl:ENSMUSG00000041481 AllianceGenome:MGI:105046
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2A2; spi2; Spi2A; Spi2-1; Spi2/eb.1
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 36.5), ovary adult (RPKM 15.7) and 14 other tissues See more
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Genomic context

Location:: 12 E; 12 53.71 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (104202406..104208198)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (104236147..104241939)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that Spi2a contributes to survival of allergenic TH2 cells
Title: Antiapoptotic serine protease inhibitors contribute to survival of allergenic T(H)2 cells.
Authors define roles for an HP-regulated Serpina3g/Spi2A intracellular serpin during granulomyelocytic, B-cell, and hematopoietic stem cell (HSC) formation.
Title: Brief report: serpin Spi2A as a novel modulator of hematopoietic progenitor cell formation.
SerpinA3g plays a role in the TNF-alpha modulation of adipose tissue development and metabolism.
Title: SerpinA3g participates in the antiadipogenesis and insulin-resistance induced by tumor necrosis factor-α in 3T3-F442A cells.
inhibition of lysosomal executioner proteases by Spi2A is a physiological mechanism by which cells are protected from caspase-independent programmed cell death
Title: Serine protease inhibitor 2A inhibits caspase-independent cell death.
Pathogenic, but not nonpathogenic, anti-DNA antibodies significantly induced a number of transcripts, including CXCL1/KC, LCN2, iNOS, CX3CL1/fractalkine, SERPINA3G, and IkappaBalpha ("marker genes").
Title: Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cytokine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease inhibitor A3G

Names: alpha-1 antiproteinase; serine (or cysteine) proteinase inhibitor, clade A, member 3G; serine protease inhibitor 2-1; serine protease inhibitor 2A; serpin 2A; serpin A3G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001353612.1 → NP_001340541.1 serine protease inhibitor A3G isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents an allele found in the reference strain. This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AA000746, AA190062, AA727578, AC142112, AI153233, AI322743, BE851987

Consensus CDS

CCDS88397.1

UniProtKB/TrEMBL

F2Z405

Related

ENSMUSP00000041250.8, ENSMUST00000043315.15

Conserved Domains (1) summary

cl00137
Location:1 → 215

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
NM_001353613.1 → NP_001340542.1 serine protease inhibitor A3G isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents an allele found in the reference strain. This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC142112, AI322743

UniProtKB/TrEMBL

Q4V9W0

Conserved Domains (1) summary

cl00137
Location:1 → 177

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
NM_009251.2 → NP_033277.2 serine protease inhibitor A3G isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents an allele found in NOD and other strains and encodes isoform 1.

Source sequence(s)

AC142112, AK156462

UniProtKB/Swiss-Prot

Q5I2A0, Q6PG99

UniProtKB/TrEMBL

Q3U0Y1

Conserved Domains (1) summary

smart00093
Location:46 → 407

SERPIN; SERine Proteinase INhibitors