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Serpinb9c serine (or cysteine) peptidase inhibitor, clade B, member 9c [ Mus musculus (house mouse) ]

Gene ID: 20707, updated on 8-Feb-2024

Summary

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Official Symbol
Serpinb9cprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 9cprovided by MGI
Primary source
MGI:MGI:894669
See related
Ensembl:ENSMUSG00000021404 AllianceGenome:MGI:894669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nk9; Spi11; 3830421J05Rik
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protease binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of endopeptidase activity; protection from natural killer cell mediated cytotoxicity; and response to bacterium. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and extracellular space. Orthologous to human SERPINB9 (serpin family B member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 27.0) See more
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Genomic context

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Location:
13 A3.3; 13 13.82 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33333258..33343737, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33149275..33159754, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prohibitin pseudogene Neighboring gene craniofacial development protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34117 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9d Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9e

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). Sun J, et al. J Biol Chem, 1997 Jun 13. PMID 9182575
  2. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365
  3. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protection from natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine (or cysteine) proteinase inhibitor, clade B, member 9c
Names
ovalbumin
serine protease inhibitor 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164524.1 → NP_001157996.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK014448, BU757932, CN704519
    Consensus CDS
    CCDS49226.1
    UniProtKB/TrEMBL
    I7HJI5, Q80WW4
    Related
    ENSMUSP00000021837.4, ENSMUST00000021837.10
    Conserved Domains (1) summary
    cl00137
    Location:17 → 387
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_011453.6 → NP_035583.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform 2

    See identical proteins and their annotated locations for NP_035583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    BC051664, BU757932
    Consensus CDS
    CCDS36629.1
    UniProtKB/TrEMBL
    Q80WW4, Q9D6A7
    Related
    ENSMUSP00000105913.2, ENSMUST00000110284.8
    Conserved Domains (1) summary
    cd19956
    Location:2 → 356
    serpinB; serpin B family, ov-serpins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    33333258..33343737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516619.2 → XP_006516682.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform X2

    See identical proteins and their annotated locations for XP_006516682.1

    UniProtKB/TrEMBL
    Q80WW4, Q9D6A7
    Conserved Domains (1) summary
    cd19956
    Location:2 → 356
    serpinB; serpin B family, ov-serpins

  2. XM_006516620.1 → XP_006516683.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform X2

    See identical proteins and their annotated locations for XP_006516683.1

    UniProtKB/TrEMBL
    Q80WW4, Q9D6A7
    Conserved Domains (1) summary
    cd19956
    Location:2 → 356
    serpinB; serpin B family, ov-serpins

  3. XM_006516618.4 → XP_006516681.1  serine (or cysteine) proteinase inhibitor, clade B, member 9c isoform X1

    UniProtKB/TrEMBL
    Q80WW4
    Conserved Domains (1) summary
    cl38926
    Location:28 → 403
    serpin; SERine Proteinase INhibitors (serpin) family
Nucleotide Protein Strain
Heading Accession and Version

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