Sox5 SRY (sex determining region Y)-box 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sox5provided by MGI
Official Full Name: SRY (sex determining region Y)-box 5provided by MGI
Primary source: MGI:MGI:98367
See related: Ensembl:ENSMUSG00000041540 AllianceGenome:MGI:98367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730017D01Rik
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cartilage condensation; chondrocyte differentiation; and positive regulation of chondrocyte differentiation. Acts upstream of or within several processes, including neurogenesis; regulation of timing of neuron differentiation; and regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SOX5 (SRY-box transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 6.6), testis adult (RPKM 6.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 76.14 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (143774151..144728008, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (143828425..144782287, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ssc-MiR-21-5p and Ssc-MiR-615 Regulates the Proliferation and Apoptosis of Leydig Cells by Targeting SOX5.
Title: Ssc-MiR-21-5p and Ssc-MiR-615 Regulates the Proliferation and Apoptosis of Leydig Cells by Targeting SOX5.
Identification of a novel Sox5 transcript in mouse testis.
Title: Identification of a novel Sox5 transcript in mouse testis.
High expression levels and localization of Sox5 in dilated cardiomyopathy.
Title: High expression levels and localization of Sox5 in dilated cardiomyopathy.
SOX-5 activates a novel RORgammat enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation.
Title: SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation.
In conclusion, our current research is the first attempt to identify SOX5 as a regulator to promote MMP-9 expression and to potentiate the migration and invasion activity in rheumatoid arthritis-fibroblast-like synoviocytes. Our data highlight the relevance of SOX5 as a potential novel therapeutic target in RA.
Title: Transcription Factor SOX5 Promotes the Migration and Invasion of Fibroblast-Like Synoviocytes in Part by Regulating MMP-9 Expression in Collagen-Induced Arthritis.
Data show that SRY-box containing gene 5 protein (Sox5) can physically bind to the collapsin response mediator protein 5 (CRMP5) promoter DNA.
Title: Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.
the novel role of Tgfb2, Fbxl18, and Tle3 in formation of Sox5, Sox6, and Sox9 dependent tissues.
Title: An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos.
Low SOX5 expression is associated with Glioma.
Title: SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells.
Study revealed that Sox5 and Sox6 prevent oligodendroglial differentiation, thus ensuring that the progenitor cells first reach their proper destination and only then lose their migratory capacity
Title: Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.
This study demonstrated that Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.
Title: Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transposon induced (1) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225315

AI528773 (e-PCR)
- UniSTS:179494

Sox5 (e-PCR), detects polymorphism
- UniSTS:471106

AJ010604 (e-PCR)
- UniSTS:163404

Sox5 (e-PCR), detects polymorphism
- UniSTS:507239

Sox5 (e-PCR), detects polymorphism
- UniSTS:144489

Sox5 (e-PCR), detects polymorphism
- UniSTS:265085

Sox5 (e-PCR), detects polymorphism
- UniSTS:265086

Sox5 (e-PCR), detects polymorphism
- UniSTS:265087

Sox5 (e-PCR), detects polymorphism
- UniSTS:265088

Sox5 (e-PCR), detects polymorphism
- UniSTS:265089

RH134712 (e-PCR)
- UniSTS:217990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	ISO Inferred from Sequence Orthology more info
involved_in cartilage condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of timing of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor SOX-5

Names: SRY-box containing gene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113559.2 → NP_001107031.2 transcription factor SOX-5 isoform b

See identical proteins and their annotated locations for NP_001107031.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AC161059, AC167021, BC110478

Consensus CDS

CCDS51954.2

UniProtKB/Swiss-Prot

O88184, O89018, P35710

UniProtKB/TrEMBL

Q2TBA9

Related

ENSMUSP00000076403.6, ENSMUST00000077160.12

Conserved Domains (1) summary

cd01388
Location:507 → 578

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001243163.1 → NP_001230092.1 transcription factor SOX-5 isoform c

See identical proteins and their annotated locations for NP_001230092.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5_ coding region and lacks an in-frame exon in the 3_ coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.

Source sequence(s)

AC161059, AC167021, AK081802, BC110478

Consensus CDS

CCDS57469.1

UniProtKB/TrEMBL

B2KFM4, X2FV61

Related

ENSMUSP00000107378.2, ENSMUST00000111749.8

Conserved Domains (1) summary

cd01388
Location:471 → 542

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001347506.1 → NP_001334435.1 transcription factor SOX-5 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in a protein (isoform d) with a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC167021, AK160154

Consensus CDS

CCDS85183.1

UniProtKB/TrEMBL

Q3TVF9

Related

ENSMUSP00000107377.2, ENSMUST00000111748.8
NM_011444.3 → NP_035574.2 transcription factor SOX-5 isoform a

See identical proteins and their annotated locations for NP_035574.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC161059, AC167021, AK081802, BC110478

Consensus CDS

CCDS39702.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

UniProtKB/TrEMBL

B2KFM9

Related

ENSMUSP00000047567.8, ENSMUST00000038815.14

Conserved Domains (1) summary

cd01388
Location:555 → 626

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

143774151..144728008 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165995.1 → XP_036021888.1 transcription factor SOX-5 isoform X16

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:493 → 564

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011241579.3 → XP_011239881.1 transcription factor SOX-5 isoform X6

See identical proteins and their annotated locations for XP_011239881.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011241582.3 → XP_011239884.1 transcription factor SOX-5 isoform X16

See identical proteins and their annotated locations for XP_011239884.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:493 → 564

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011241577.3 → XP_011239879.1 transcription factor SOX-5 isoform X6

See identical proteins and their annotated locations for XP_011239879.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165997.1 → XP_036021890.1 transcription factor SOX-5 isoform X18

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:458 → 529

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165992.1 → XP_036021885.1 transcription factor SOX-5 isoform X13

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:507 → 578

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165986.1 → XP_036021879.1 transcription factor SOX-5 isoform X12

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:508 → 579

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165988.1 → XP_036021881.1 transcription factor SOX-5 isoform X12

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:508 → 579

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165996.1 → XP_036021889.1 transcription factor SOX-5 isoform X18

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:458 → 529

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165991.1 → XP_036021884.1 transcription factor SOX-5 isoform X13

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:507 → 578

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011241581.3 → XP_011239883.1 transcription factor SOX-5 isoform X12

See identical proteins and their annotated locations for XP_011239883.1

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:508 → 579

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165993.1 → XP_036021886.1 transcription factor SOX-5 isoform X13

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:507 → 578

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165987.1 → XP_036021880.1 transcription factor SOX-5 isoform X12

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:508 → 579

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011241578.3 → XP_011239880.1 transcription factor SOX-5 isoform X6

See identical proteins and their annotated locations for XP_011239880.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506938.5 → XP_006507001.1 transcription factor SOX-5 isoform X8

See identical proteins and their annotated locations for XP_006507001.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:535 → 606

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030255287.2 → XP_030111147.1 transcription factor SOX-5 isoform X9

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:534 → 605

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506931.5 → XP_006506994.1 transcription factor SOX-5 isoform X1

See identical proteins and their annotated locations for XP_006506994.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:584 → 655

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506932.5 → XP_006506995.1 transcription factor SOX-5 isoform X2

See identical proteins and their annotated locations for XP_006506995.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:583 → 654

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506942.5 → XP_006507005.1 transcription factor SOX-5 isoform X15

See identical proteins and their annotated locations for XP_006507005.1

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:499 → 570

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506934.5 → XP_006506997.1 transcription factor SOX-5 isoform X4

See identical proteins and their annotated locations for XP_006506997.1

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:549 → 620

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506935.5 → XP_006506998.1 transcription factor SOX-5 isoform X5

See identical proteins and their annotated locations for XP_006506998.1

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:548 → 619

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_017321475.3 → XP_017176964.1 transcription factor SOX-5 isoform X17

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:472 → 543

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030255290.2 → XP_030111150.1 transcription factor SOX-5 isoform X14

UniProtKB/Swiss-Prot

O88184, O89018, P35710

UniProtKB/TrEMBL

E9PVR0

Related

ENSMUSP00000133041.3, ENSMUST00000170367.9

Conserved Domains (1) summary

cd01388
Location:506 → 577

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506933.5 → XP_006506996.1 transcription factor SOX-5 isoform X3

See identical proteins and their annotated locations for XP_006506996.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:556 → 627

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506939.5 → XP_006507002.1 transcription factor SOX-5 isoform X10

See identical proteins and their annotated locations for XP_006507002.1

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:521 → 592

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011241580.4 → XP_011239882.1 transcription factor SOX-5 isoform X11

See identical proteins and their annotated locations for XP_011239882.1

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:520 → 591

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165998.1 → XP_036021891.1 transcription factor SOX-5 isoform X18

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:458 → 529

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030255289.2 → XP_030111149.1 transcription factor SOX-5 isoform X13

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:507 → 578

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506940.5 → XP_006507003.1 transcription factor SOX-5 isoform X12

See identical proteins and their annotated locations for XP_006507003.1

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:508 → 579

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506936.5 → XP_006506999.1 transcription factor SOX-5 isoform X6

See identical proteins and their annotated locations for XP_006506999.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506941.5 → XP_006507004.1 transcription factor SOX-5 isoform X13

See identical proteins and their annotated locations for XP_006507004.1

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:507 → 578

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165989.1 → XP_036021882.1 transcription factor SOX-5 isoform X12

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:508 → 579

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506937.5 → XP_006507000.1 transcription factor SOX-5 isoform X6

See identical proteins and their annotated locations for XP_006507000.1

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165999.1 → XP_036021892.1 transcription factor SOX-5 isoform X18

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:458 → 529

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165985.1 → XP_036021878.1 transcription factor SOX-5 isoform X7

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:542 → 613

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165984.1 → XP_036021877.1 transcription factor SOX-5 isoform X6

UniProtKB/Swiss-Prot

O88184, O89018, P35710

Conserved Domains (1) summary

cd01388
Location:543 → 614

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165990.1 → XP_036021883.1 transcription factor SOX-5 isoform X12

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:508 → 579

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036165994.1 → XP_036021887.1 transcription factor SOX-5 isoform X13

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:507 → 578

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036166000.1 → XP_036021893.1 transcription factor SOX-5 isoform X18

UniProtKB/TrEMBL

X2FV61

Conserved Domains (1) summary

cd01388
Location:458 → 529

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006506945.5 → XP_006507008.1 transcription factor SOX-5 isoform X20

See identical proteins and their annotated locations for XP_006507008.1

Conserved Domains (1) summary

cd01388
Location:233 → 304

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036166001.1 → XP_036021894.1 transcription factor SOX-5 isoform X19

Conserved Domains (1) summary

cd01388
Location:262 → 333

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...