Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a4provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 4provided by MGI
Primary source: MGI:MGI:95758
See related: Ensembl:ENSMUSG00000018566 AllianceGenome:MGI:95758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GT2; twgy; Glut4; Glut-4
Summary: Enables glucose transmembrane transporter activity. Involved in cellular response to insulin stimulus. Acts upstream of or within several processes, including amylopectin biosynthetic process; brown fat cell differentiation; and glucose import in response to insulin stimulus. Located in several cellular components, including cytoplasmic vesicle; extracellular exosome; and sarcolemma. Is integral component of plasma membrane. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; brain; and genitourinary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 161.8), mammary gland adult (RPKM 97.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.93 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69833112..69839040, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69942286..69948216, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell Surface.
Title: Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell Surface.
LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes.
Title: LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes.
Bone marrow mesenchymal stem cell-derived exosomes reduce insulin resistance and obesity in mice via the PI3K/AKT signaling pathway.
Title: Bone marrow mesenchymal stem cell-derived exosomes reduce insulin resistance and obesity in mice via the PI3K/AKT signaling pathway.
Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle.
Title: Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle.
Tectorigenin targets PKACalpha to promote GLUT4 expression in skeletal muscle and improve insulin resistance in vitro and in vivo.
Title: Tectorigenin targets PKACα to promote GLUT4 expression in skeletal muscle and improve insulin resistance in vitro and in vivo.
Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4[+/-] mice.
Title: Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4(+/-) mice.
GSK3alpha phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells.
Title: GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells.
A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.
Title: A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.
MYH10 Governs Adipocyte Function and Adipogenesis through Its Interaction with GLUT4.
Title: MYH10 Governs Adipocyte Function and Adipogenesis through Its Interaction with GLUT4.
Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice.
Title: Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice.

Submit: New GeneRIF Correction See all GeneRIFs (356)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc2a4 (e-PCR), detects polymorphism
- UniSTS:547074

NoName (e-PCR)
- UniSTS:547075

Slc2a4 (e-PCR), detects polymorphism
- UniSTS:547075

Slc2a4 (e-PCR), detects polymorphism
- UniSTS:144427

Slc2a4 (e-PCR), detects polymorphism
- UniSTS:144428

Slc2a4 (e-PCR), detects polymorphism
- UniSTS:144429

D11Mit15 (e-PCR), detects polymorphism
- UniSTS:126341

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables glucose uniporter activity	ISO Inferred from Sequence Orthology more info
enables insulin-responsive glucose:proton symporter activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amylopectin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within carbohydrate transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose import in response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose import in response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose import in response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose transmembrane transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect long-term memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of brain-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect short-term memory	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
located_in insulin-responsive compartment	IDA Inferred from Direct Assay more info	PubMed
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 4

Names: glucose transporter type 4, insulin-responsive

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359114.1 → NP_001346043.1 solute carrier family 2, facilitated glucose transporter member 4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK137607, BY096615, BY226822

Conserved Domains (1) summary

cl28910
Location:1 → 382

MFS; Major Facilitator Superfamily
NM_009204.2 → NP_033230.2 solute carrier family 2, facilitated glucose transporter member 4 isoform 1

See identical proteins and their annotated locations for NP_033230.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK137607, AL596185

Consensus CDS

CCDS36201.1

UniProtKB/Swiss-Prot

P14142, Q3TPK6, Q9JJN9

UniProtKB/TrEMBL

J3QK17

Related

ENSMUSP00000018710.7, ENSMUST00000018710.13

Conserved Domains (2) summary

cd06174
Location:78 → 447

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:27 → 483

Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69833112..69839040 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245725.2 → XP_030101585.1 solute carrier family 2, facilitated glucose transporter member 4 isoform X2

Conserved Domains (1) summary

cl28910
Location:1 → 317

MFS; Major Facilitator Superfamily
XM_006532655.4 → XP_006532718.1 solute carrier family 2, facilitated glucose transporter member 4 isoform X2

See identical proteins and their annotated locations for XP_006532718.1

Conserved Domains (1) summary

cl28910
Location:1 → 317

MFS; Major Facilitator Superfamily
XM_006532654.3 → XP_006532717.1 solute carrier family 2, facilitated glucose transporter member 4 isoform X1

See identical proteins and their annotated locations for XP_006532717.1

Conserved Domains (1) summary

cl28910
Location:1 → 382

MFS; Major Facilitator Superfamily