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Sec61g SEC61 translocon subunit gamma [ Mus musculus (house mouse) ]

Gene ID: 20335, updated on 11-Apr-2024

Summary

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Official Symbol
Sec61gprovided by MGI
Official Full Name
SEC61 translocon subunit gammaprovided by MGI
Primary source
MGI:MGI:1202066
See related
Ensembl:ENSMUSG00000078974 AllianceGenome:MGI:1202066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein transmembrane transporter activity. Predicted to be involved in posttranslational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Ssh1 translocon complex. Is expressed in lung epithelium; ovary; and seminiferous cord. Orthologous to human SEC61G (SEC61 translocon subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 73.5), placenta adult (RPKM 63.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A2; 11 9.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16451638..16458484, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16501638..16508484, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 2A Neighboring gene STARR-seq mESC enhancer starr_28683 Neighboring gene STARR-seq mESC enhancer starr_28684 Neighboring gene STARR-seq mESC enhancer starr_28685 Neighboring gene predicted gene 12012 Neighboring gene STARR-seq mESC enhancer starr_28687 Neighboring gene STARR-positive B cell enhancer ABC_E11470 Neighboring gene STARR-seq mESC enhancer starr_28688 Neighboring gene thymoma viral proto-oncogene 2, pseudogene Neighboring gene VISTA enhancer mm1103 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts. Gordon HM, et al. J Immunol, 1992 Jun 15. PMID 1602141
  2. Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Saito K, et al. Proc Natl Acad Sci U S A, 2009 May 19. PMID 19416849, Free PMC Article
  3. Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Liu Y, et al. Gene Expr Patterns, 2002 Dec. PMID 12617806
  4. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
  5. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEC61G assists EGFR-amplified glioblastoma to evade immune elimination.
    Title: SEC61G assists EGFR-amplified glioblastoma to evade immune elimination.
  2. Sec61gamma is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.
    Title: Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ssh1 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
protein transport protein Sec61 subunit gamma
Names
SEC61, gamma subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109971.1 → NP_001103441.1  protein transport protein Sec61 subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_001103441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate segment in exon 1, compared to variant 1. This causes translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK012393, AK012644, BY468217, CO808059
    Consensus CDS
    CCDS48755.1
    UniProtKB/Swiss-Prot
    P60060
    UniProtKB/TrEMBL
    Q5SWJ8
    Related
    ENSMUSP00000137362.2, ENSMUST00000178855.8
    Conserved Domains (1) summary
    cl00481
    Location:12 → 68
    SecE; SecE/Sec61-gamma subunits of protein translocation complex

  2. NM_001109972.1 → NP_001103442.1  protein transport protein Sec61 subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_001103442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate segment in exon 1, compared to variant 1. This causes translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK012644, AV456975, CO808059
    Consensus CDS
    CCDS48755.1
    UniProtKB/Swiss-Prot
    P60060
    UniProtKB/TrEMBL
    Q5SWJ8
    Related
    ENSMUSP00000105270.2, ENSMUST00000109642.8
    Conserved Domains (1) summary
    cl00481
    Location:12 → 68
    SecE; SecE/Sec61-gamma subunits of protein translocation complex

  3. NM_011343.3 → NP_035473.2  protein transport protein Sec61 subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_035473.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK012644, CO808059
    Consensus CDS
    CCDS48756.1
    UniProtKB/TrEMBL
    G3UWH0
    Related
    ENSMUSP00000132348.2, ENSMUST00000166950.8
    Conserved Domains (1) summary
    cl00481
    Location:44 → 100
    SecE; SecE/Sec61-gamma subunits of protein translocation complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    16451638..16458484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60060.1 GenPept UniProtKB/Swiss-Prot:P60060

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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