Sct secretin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sctprovided by MGI
Official Full Name: secretinprovided by MGI
Primary source: MGI:MGI:99466
See related: Ensembl:ENSMUSG00000038580 AllianceGenome:MGI:99466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone. [provided by RefSeq, Jul 2015]
Expression: Biased expression in placenta adult (RPKM 726.5), duodenum adult (RPKM 163.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.59 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140858243..140859082, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141278329..141279174, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of secretin gene knockout on the diversity, composition, and function of gut microbiota in adult male mice.
Title: Effects of secretin gene knockout on the diversity, composition, and function of gut microbiota in adult male mice.
Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Title: Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice.
Title: Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice.
Transcript level of Bcl-2 and Bcl-xL is reduced in the cerebellum of Sct-deficient mice.
Title: Secretin Prevents Apoptosis in the Developing Cerebellum Through Bcl-2 and Bcl-xL.
increases TGF-beta1 levels by a microRNA 125b-dependent mechanism
Title: Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(-/-) mice by diminishing senescence of cholangiocytes.
The increased calcium response mediated by secretin in the absence of GLP-1R was paralleled by an increased glucose-dependent insulin response, indicating that the heterodimeric receptor complexes modulate secretin responses.
Title: Coexpressed Class B G Protein-Coupled Secretin and GLP-1 Receptors Self- and Cross-Associate: Impact on Pancreatic Islets.
Study demonstrates that secretin-induced dendritic oxytocin release from supraoptic neurons enhances social recognition. The newly defined secretin-oxytocin system may lead to a possible treatment for social deficits.
Title: Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition.
Secretin expression is not detected under delayed implantation but is stimulated after estrogen activation and under artificial decidualization.
Title: Progesterone regulates secretin expression in mouse uterus during early pregnancy.
Results suggest a role in motor coordination and motor learning for SCT expressed in cerebellar Purkinje cells
Title: The knockout of secretin in cerebellar Purkinje cells impairs mouse motor coordination and motor learning.
a novel positive feedback pathway involving secretin and CD36 to enhance intestinal lipid absorption is being proposed.
Title: Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables digestive hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diet induced thermogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gastrin-induced gastric acid secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gastrin-induced gastric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pancreatic juice secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of somatostatin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of somatostatin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287171.2 → NP_001274100.1 secretin isoform 1 precursor

See identical proteins and their annotated locations for NP_001274100.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC163434

Consensus CDS

CCDS72069.1

UniProtKB/TrEMBL

Q3TJJ8, Q80ZS9

Related

ENSMUSP00000041519.7, ENSMUST00000046156.13

Conserved Domains (1) summary

smart00070
Location:32 → 58

GLUCA; Glucagon like hormones
NM_001309439.2 → NP_001296368.1 secretin isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate splice sites in internal exons, including one in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC163434

Consensus CDS

CCDS85457.1

UniProtKB/TrEMBL

A0A1B0GS37

Related

ENSMUSP00000147780.2, ENSMUST00000211667.2

Conserved Domains (1) summary

cl27746
Location:32 → 58

Hormone_2; Peptide hormone
NM_011328.4 → NP_035458.1 secretin isoform 2 preproprotein

See identical proteins and their annotated locations for NP_035458.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC163434

Consensus CDS

CCDS40184.1

UniProtKB/Swiss-Prot

Q08535

UniProtKB/TrEMBL

Q3TJJ8, Q3UKU8

Related

ENSMUSP00000128729.2, ENSMUST00000167790.3

Conserved Domains (1) summary

smart00070
Location:32 → 58

GLUCA; Glucagon like hormones

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

140858243..140859082 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322065.3 → XP_017177554.1 secretin isoform X1

UniProtKB/TrEMBL

A0A1B0GS37

Conserved Domains (1) summary

cl27746
Location:32 → 58

Hormone_2; Peptide hormone