Sat1 spermidine/spermine N1-acetyl transferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sat1provided by MGI
Official Full Name: spermidine/spermine N1-acetyl transferase 1provided by MGI
Primary source: MGI:MGI:98233
See related: Ensembl:ENSMUSG00000025283 AllianceGenome:MGI:98233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sat; SSAT
Summary: Predicted to enable diamine N-acetyltransferase activity; identical protein binding activity; and spermidine binding activity. Acts upstream of or within regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 89.1), placenta adult (RPKM 43.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F3; X 72.38 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (153996128..153999345, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (155213126..155216449, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus.
Title: Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus.
Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.
Title: Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.
Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.
Title: Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.
SAT1 activation plays a key role in cold and beta3-AR agonist-induced beige adipocyte biogenesis and low-grade inflammation.
Title: Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beige adipocyte biogenesis.
the level of SSAT enzyme activity affected osteoblastogenesis and hence influenced bone remodeling and the bone phenotype in mice
Title: Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype.
Enhanced SSAT expression by proximal tubule epithelial cells leads to tubular damage, and its deficiency reduces the severity of renal I/R injury through reduction of cellular damage and modulation of the innate immune response
Title: Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.
The SSAT overexpression and the concomitantly accelerated polyamine metabolism in hematopoietic cells and bone marrow microenvironment affect lineage commitment and lead to the development of a mouse myeloproliferative disease in SSAT mice.
Title: Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N¹-acetyltransferase.
the results indicate that transcriptional modulation of the SAT1 gene is not a significant component of the hyperoxaluria observed in these rat models
Title: Hyperoxaluric rats do not exhibit alterations in renal expression patterns of Slc26a1 (SAT1) mRNA or protein.
study suggests that SSAT overexpression obtained in SSAT mice enhances the anti-inflammatory actions in the acute phase of LPS-induced immune response
Title: Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N1-acetyltransferase (SSAT) overexpressing mice.
Expression of SSAT increases in kidneys subjected to endotoxic acute kidney injury and that increased polyamine back conversion and oxidation contribute to tubular damage in endotoxin-induced AKI.
Title: The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:238100

Sat1 (e-PCR), detects polymorphism
- UniSTS:531487

Sat1 (e-PCR), detects polymorphism
- UniSTS:507205

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables diamine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables spermidine binding	IBA Inferred from Biological aspect of Ancestor more info
enables spermidine binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in polyamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in polyamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in polyamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermidine acetylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermine catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: diamine acetyltransferase 1

Names: SSAT-1; polyamine N-acetyltransferase 1; putrescine acetyltransferase; spermidine/spermine N(1)-acetyltransferase 1

NP_001412931.1

EC 2.3.1.57

NP_033147.1

EC 2.3.1.57

XP_036017762.1

EC 2.3.1.57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426002.1 → NP_001412931.1 diamine acetyltransferase 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longer isoform (3).

Source sequence(s)

BX119978, BX119986

UniProtKB/TrEMBL

A2BES2
NM_009121.5 → NP_033147.1 diamine acetyltransferase 1 isoform 1

See identical proteins and their annotated locations for NP_033147.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

BX119978, BX119986

Consensus CDS

CCDS30495.1

UniProtKB/Swiss-Prot

P48026, Q3U444

Related

ENSMUSP00000026318.9, ENSMUST00000026318.15

Conserved Domains (1) summary

pfam00583
Location:48 → 144

Acetyltransf_1; Acetyltransferase (GNAT) family

RNA

NR_189657.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BX119978, BX119986
NR_189658.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BX119978, BX119986

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

153996128..153999345 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161869.1 → XP_036017762.1 diamine acetyltransferase 1 isoform X1

UniProtKB/TrEMBL

Q3V2Q2

Related

ENSMUST00000150046.2

Conserved Domains (1) summary

pfam00583
Location:4 → 69

Acetyltransf_1; Acetyltransferase (GNAT) family