U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rrh retinal pigment epithelium derived rhodopsin homolog [ Mus musculus (house mouse) ]

Gene ID: 20132, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Rrhprovided by MGI
Official Full Name
retinal pigment epithelium derived rhodopsin homologprovided by MGI
Primary source
MGI:MGI:1097709
See related
Ensembl:ENSMUSG00000028012 AllianceGenome:MGI:1097709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to act upstream of or within protein-chromophore linkage and signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in photoreceptor outer segment. Predicted to be integral component of plasma membrane. Is expressed in eye. Orthologous to human RRH (retinal pigment epithelium-derived rhodopsin homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 1.6), testis adult (RPKM 0.2) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 G3; 3 59.09 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129596837..129618140, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129808575..129822505, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E827 Neighboring gene STARR-seq mESC enhancer starr_08971 Neighboring gene STARR-seq mESC enhancer starr_08975 Neighboring gene STARR-seq mESC enhancer starr_08976 Neighboring gene predicted gene, 35986 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:129256142-129256329 Neighboring gene ELOVL fatty acid elongase 6 Neighboring gene STARR-seq mESC enhancer starr_08981 Neighboring gene epidermal growth factor Neighboring gene STARR-positive B cell enhancer ABC_E6124 Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene predicted gene, 36130 Neighboring gene STARR-positive B cell enhancer ABC_E7942 Neighboring gene GAR1 ribonucleoprotein Neighboring gene predicted gene, 36180 Neighboring gene complement component factor i

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. Cook JD, et al. J Biol Chem, 2017 Dec 29. PMID 29109151, Free PMC Article
  2. Expression of opsin genes early in ocular development of humans and mice. Tarttelin EE, et al. Exp Eye Res, 2003 Mar. PMID 12573668
  3. Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. Sun H, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275222, Free PMC Article
  4. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables photoreceptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
visual pigment-like receptor peropsin
Names
peropsin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409853.1 → NP_001396782.1  visual pigment-like receptor peropsin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC111097
    UniProtKB/TrEMBL
    Q80XL3
    Related
    ENSMUSP00000029648.8, ENSMUST00000029648.11

  2. NM_001409854.1 → NP_001396783.1  visual pigment-like receptor peropsin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC111097

  3. NM_001409855.1 → NP_001396784.1  visual pigment-like receptor peropsin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC111097

  4. NM_001409856.1 → NP_001396785.1  visual pigment-like receptor peropsin isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC111097
    UniProtKB/TrEMBL
    A0A0G2JF76
    Related
    ENSMUSP00000143054.2, ENSMUST00000200079.5

  5. NM_009102.4 → NP_033128.1  visual pigment-like receptor peropsin isoform 2

    See identical proteins and their annotated locations for NP_033128.1

    Status: VALIDATED

    Source sequence(s)
    AC111097
    Consensus CDS
    CCDS38633.1
    UniProtKB/Swiss-Prot
    O35214
    UniProtKB/TrEMBL
    Q543W9
    Related
    ENSMUSP00000143093.2, ENSMUST00000196902.5
    Conserved Domains (1) summary
    pfam00001
    Location:43 → 294
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    129596837..129618140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319507.2 → XP_017174996.1  visual pigment-like receptor peropsin isoform X2

    UniProtKB/TrEMBL
    Q9D1T9
    Conserved Domains (2) summary
    cd14964
    Location:6 → 24
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 170
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_036162965.1 → XP_036018858.1  visual pigment-like receptor peropsin isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:27 → 53
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:26 → 104
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35214.1 GenPept UniProtKB/Swiss-Prot:O35214

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous