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MCEMP1 mast cell expressed membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 199675, updated on 10-Mar-2024

Summary

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Official Symbol
MCEMP1provided by HGNC
Official Full Name
mast cell expressed membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:27291
See related
Ensembl:ENSG00000183019 MIM:609565; AllianceGenome:HGNC:27291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf59
Summary
This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 39.7), bone marrow (RPKM 28.1) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
19p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7677090..7679829)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7677976..7680714)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7741976..7744715)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RPS27A pseudogene 19 Neighboring gene resistin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9990 Neighboring gene Sharpr-MPRA regulatory region 435 Neighboring gene trafficking protein particle complex subunit 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:7749795-7749977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13895 Neighboring gene Fc epsilon receptor II Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis. Raman K, et al. Stroke, 2016 Mar. PMID 26846866
  2. Identification and expression of a new type II transmembrane protein in human mast cells. Li K, et al. Genomics, 2005 Jul. PMID 15953541
  3. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. Denner J, et al. PLoS One, 2013. PMID 23383108, Free PMC Article
  4. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFbeta-dependent manner.
    Title: Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ-dependent manner.
  2. The expression of the gene MCEMP1 had the strongest association with stroke of 11,181 genes tested.
    Title: Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chromosome 19 open reading frame 59 (C19orf59; MCEMP1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC132456

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
mast cell-expressed membrane protein 1
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174918.3 → NP_777578.3  mast cell-expressed membrane protein 1

    Status: REVIEWED

    Source sequence(s)
    AC008763
    Consensus CDS
    CCDS12183.2
    UniProtKB/Swiss-Prot
    Q8IX19, Q8IX20
    UniProtKB/TrEMBL
    A0A384NYE9
    Related
    ENSP00000329920.3, ENST00000333598.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    7677090..7679829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    7677976..7680714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IX19.1 GenPept UniProtKB/Swiss-Prot:Q8IX19

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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