Trim27 tripartite motif-containing 27 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim27provided by MGI
Official Full Name: tripartite motif-containing 27provided by MGI
Primary source: MGI:MGI:97904
See related: Ensembl:ENSMUSG00000021326 AllianceGenome:MGI:97904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rfp; Gm19403
Summary: Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin-like protein transferase activity. Involved in innate immune response; negative regulation of viral transcription; and suppression of viral release by host. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of actin nucleation. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and retina. Orthologous to human TRIM27 (tripartite motif containing 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 33.3), adrenal adult (RPKM 32.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 7.67 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (21363570..21378893)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (21179450..21194723)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL14 promotes IL-6-induced viability, glycolysis and inflammation in HaCaT cells via the m6A modification of TRIM27.
Title: METTL14 promotes IL-6-induced viability, glycolysis and inflammation in HaCaT cells via the m6A modification of TRIM27.
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling.
Title: TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling.
Knockdown of TRIM27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of PPARgamma and reducing NOX4 expression.
Title: Knockdown of TRIM27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of PPARγ and reducing NOX4 expression.
Tripartite Motif-Containing 27 Attenuates Liver Ischemia/Reperfusion Injury by Suppressing Transforming Growth Factor beta-Activated Kinase 1 (TAK1) by TAK1 Binding Protein 2/3 Degradation.
Title: Tripartite Motif-Containing 27 Attenuates Liver Ischemia/Reperfusion Injury by Suppressing Transforming Growth Factor β-Activated Kinase 1 (TAK1) by TAK1 Binding Protein 2/3 Degradation.
Tri-domain proteins 27 reduce inflammation and apoptosis in HK-2 cells and protect against acute kidney injury in mice.
Title: Tri-domain proteins 27 reduce inflammation and apoptosis in HK-2 cells and protect against acute kidney injury in mice.
The roles of Trim27 in hematopoiesis were studied by enforcing its expression in mouse hematopoietic stem and progenitor cells (HSPC). Ectopic expression of Trim27 in mouse fetal liver HSPC confers repopulating advantage with myeloid dominance. Trim27 up-regulated essential regulators of myelopoiesis.The myeloproliferative advantage caused by overexpressing Trim27/TRIM27 is conserved between mouse and human hematopoiesis.
Title: Trim27 confers myeloid hematopoiesis competitiveness by up-regulating myeloid master genes.
Deficiency of TRIM27 significantly impairs dextran sulfate sodium (DSS)-induced STAT3 activation, inflammatory cytokine expression and colitis as well as azoxymethane (AOM)/DSS-induced colitis-associated cancer in mice
Title: TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.
Trim27 connecting Slx2 may regulate meiotic processes in multiple ways by influencing XY body formation and germ cell proliferation during spermatogenesis.
Title: Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis.
our study suggests that nicotine may induce murine spermatozoal apoptosis via the TNF apoptotic pathway through up-regulation of deubiquitinated RIP1 by Trim27 promoter hypomethylation.
Title: Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation.
TRIM27 inhibits VSV infection-induced type I IFN production by promoting TBK1 degradation.
Title: Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3)
Targeted (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB276471 (e-PCR)
- UniSTS:208897

L46855 (e-PCR)
- UniSTS:180489

AW538890 (e-PCR)
- UniSTS:180490

TRIM27 (e-PCR)
- UniSTS:505620

RH142154 (e-PCR)
- UniSTS:125843

Trim27 (e-PCR), detects polymorphism
- UniSTS:527585

RH128894 (e-PCR)
- UniSTS:212202

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of actin nucleation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in suppression of viral release by host	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein RFP

Names: RING-type E3 ubiquitin transferase TRIM27; ret finger protein; tripartite motif protein 27; tripartite motif-containing protein 27

NP_033080.2

EC 2.3.2.27

XP_006516669.1

EC 2.3.2.27

XP_036013819.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429048.1 → NP_001415977.1 zinc finger protein RFP isoform 2

Status: VALIDATED

Source sequence(s)

AC138330
NM_001429049.1 → NP_001415978.1 zinc finger protein RFP isoform 3

Status: VALIDATED

Source sequence(s)

AC138330
NM_001429050.1 → NP_001415979.1 zinc finger protein RFP isoform 4

Status: VALIDATED

Source sequence(s)

AC138330
NM_001429051.1 → NP_001415980.1 zinc finger protein RFP isoform 5

Status: VALIDATED

Source sequence(s)

AC138330
NM_009054.4 → NP_033080.2 zinc finger protein RFP isoform 1

See identical proteins and their annotated locations for NP_033080.2

Status: VALIDATED

Source sequence(s)

AC138330

Consensus CDS

CCDS36607.1

UniProtKB/Swiss-Prot

Q62157, Q62158, Q8C2Q5, Q99LK1

UniProtKB/TrEMBL

Q6NSS3

Related

ENSMUSP00000021761.6, ENSMUST00000021761.13

Conserved Domains (4) summary

COG1196
Location:140 → 312

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd15814
Location:315 → 491

SPRY_PRY_TRIM27; PRY/SPRY domain in tripartite motif-containing protein 27 (TRIM27), also known as RING finger protein 76 (RNF76)

cd16594
Location:13 → 57

RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

cd19762
Location:94 → 137

Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

RNA

NR_190573.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC138330

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

21363570..21378893

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157926.1 → XP_036013819.1 zinc finger protein RFP isoform X1

UniProtKB/Swiss-Prot

Q62157, Q62158, Q8C2Q5, Q99LK1

UniProtKB/TrEMBL

Q6NSS3

Conserved Domains (4) summary

COG1196
Location:140 → 312

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd15814
Location:315 → 491

SPRY_PRY_TRIM27; PRY/SPRY domain in tripartite motif-containing protein 27 (TRIM27), also known as RING finger protein 76 (RNF76)

cd16594
Location:13 → 57

RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

cd19762
Location:94 → 137

Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
XM_006516606.3 → XP_006516669.1 zinc finger protein RFP isoform X1

See identical proteins and their annotated locations for XP_006516669.1

UniProtKB/Swiss-Prot

Q62157, Q62158, Q8C2Q5, Q99LK1

UniProtKB/TrEMBL

Q6NSS3

Related

ENSMUSP00000152730.2, ENSMUST00000222544.2

Conserved Domains (4) summary

COG1196
Location:140 → 312

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd15814
Location:315 → 491

SPRY_PRY_TRIM27; PRY/SPRY domain in tripartite motif-containing protein 27 (TRIM27), also known as RING finger protein 76 (RNF76)

cd16594
Location:13 → 57

RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

cd19762
Location:94 → 137

Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins