Rdx radixin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rdxprovided by MGI
Official Full Name: radixinprovided by MGI
Primary source: MGI:MGI:97887
See related: Ensembl:ENSMUSG00000032050 AllianceGenome:MGI:97887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables protein domain specific binding activity. Involved in cellular response to thyroid hormone stimulus; establishment of protein localization; and positive regulation of G1/S transition of mitotic cell cycle. Acts upstream of or within apical protein localization and microvillus assembly. Located in several cellular components, including lamellipodium; microvillus; and ruffle. Colocalizes with plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Used to study Dubin-Johnson syndrome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 32.7), placenta adult (RPKM 29.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 28.62 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (51958450..52000038)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (52047150..52088738)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results showed that Among designated developmental stages, RDX has highest fold difference in early embryonic and postnatal stages.
Title: Deciphering brain-specific transcriptomic expression of Ezr, Rad and Msn genes in the development of Mus musculus.
LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia.
Title: The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.
Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP.
Title: The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins.
identification of radixin as a PRG-2 interaction partner and showing that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2
Title: Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.
This study describes a novel mechanism that regulates plasma receptor pools in the control of synaptic receptor density.
Title: Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
These results indicate that radixin plays an important role in regulating P-glycoprotein localization and P-glycoprotein functional activity at the intestinal membrane.
Title: Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo.
The specific location of radixin-positive cells in the peri-infarct region and in microglia suggests a role for radixin in microglial activation after stroke.
Title: Radixin expression in microglia after cortical stroke lesion.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
Title: A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin proteins and the formation of phagocytic cup-like structures on neuronal dendrites
Title: Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin.
Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein.
Title: Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical protein localization	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in cellular response to thyroid hormone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microvillus assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rap protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell tip	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium base	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: radixin

Names: ESP10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104616.1 → NP_001098086.1 radixin isoform a

See identical proteins and their annotated locations for NP_001098086.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).

Source sequence(s)

AK162204, BE994963, DV662898

Consensus CDS

CCDS40634.1

UniProtKB/Swiss-Prot

P26043, Q3TS85, Q9QW27

UniProtKB/TrEMBL

Q3UJJ8

Related

ENSMUSP00000128249.2, ENSMUST00000163153.9

Conserved Domains (3) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 583

ERM; Ezrin/radixin/moesin family
NM_001104617.1 → NP_001098087.1 radixin isoform b

See identical proteins and their annotated locations for NP_001098087.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks multiple 3' coding exons and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AK016711, BC053417, BY739389

Consensus CDS

CCDS52793.1

UniProtKB/TrEMBL

Q7TSG6, Q8C2N4

Related

ENSMUSP00000055303.10, ENSMUST00000061352.11

Conserved Domains (4) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:91 → 206

FERM_M; FERM central domain

pfam09379
Location:9 → 71

FERM_N; FERM N-terminal domain
NM_009041.3 → NP_033067.2 radixin isoform a

See identical proteins and their annotated locations for NP_033067.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform a). Variants 1 and 2 encode the same protein.

Source sequence(s)

AK162204, AK168449, BE994963, BY739389

Consensus CDS

CCDS40634.1

UniProtKB/Swiss-Prot

P26043, Q3TS85, Q9QW27

UniProtKB/TrEMBL

Q3UJJ8

Related

ENSMUSP00000000590.9, ENSMUST00000000590.16

Conserved Domains (3) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 583

ERM; Ezrin/radixin/moesin family