lmna lamin A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lmnaprovided by ZNC
Official Full Name: lamin Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020424-3
See related: Ensembl:ENSDARG00000013415 AllianceGenome:ZFIN:ZDB-GENE-020424-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb948; wu:fk66d12
Summary: Acts upstream of or within heart contraction and regulation of cell aging. Predicted to be located in intermediate filament. Is expressed in several structures, including fin; head; mesoderm; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (30520857..30569587, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (30562930..30611687, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results have important implications for understanding the tissue-specific regulation and functions of the lamin A gene
Title: Identification of tissue-specific regulatory region in the zebrafish lamin A promoter.
The induction of embryonic senescence and laminopathies in zebrafish harboring disturbed expressions of the lamin A gene, is described.
Title: Embryonic senescence and laminopathies in a progeroid zebrafish model.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fl21a02.x1 (e-PCR)
- UniSTS:202049

fk66d12.x1 (e-PCR)
- UniSTS:201393

fk69d08.x1 (e-PCR)
- UniSTS:201428

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear lamina	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lamin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152971.1 → NP_694503.1 lamin

See identical proteins and their annotated locations for NP_694503.1

Status: PROVISIONAL

Source sequence(s)

AF397016

UniProtKB/TrEMBL

Q90XD7

Related

ENSDARP00000153174.1, ENSDART00000191716.1

Conserved Domains (6) summary

pfam00038
Location:27 → 383

Filament; Intermediate filament protein

pfam00932
Location:451 → 559

LTD; Lamin Tail Domain

pfam02601
Location:322 → 400

Exonuc_VII_L; Exonuclease VII, large subunit

pfam04871
Location:102 → 202

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

pfam06156
Location:295 → 359

DUF972; Protein of unknown function (DUF972)

cl12013
Location:237 → 350

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

30520857..30569587 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158168.4 → XP_005158225.1 lamin isoform X1

See identical proteins and their annotated locations for XP_005158225.1

UniProtKB/TrEMBL

B3DKC5, B3DKD3

Related

ENSDARP00000145959.1, ENSDART00000191040.1

Conserved Domains (6) summary

pfam00038
Location:27 → 383

Filament; Intermediate filament protein

pfam00932
Location:451 → 559

LTD; Lamin Tail Domain

pfam02601
Location:322 → 400

Exonuc_VII_L; Exonuclease VII, large subunit

pfam04871
Location:102 → 202

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

pfam06156
Location:295 → 359

DUF972; Protein of unknown function (DUF972)

cl12013
Location:237 → 350

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_005158167.4 → XP_005158224.1 lamin isoform X1

See identical proteins and their annotated locations for XP_005158224.1

UniProtKB/TrEMBL

B3DKC5, B3DKD3

Related

ENSDARP00000113049.1, ENSDART00000145087.2

Conserved Domains (6) summary

pfam00038
Location:27 → 383

Filament; Intermediate filament protein

pfam00932
Location:451 → 559

LTD; Lamin Tail Domain

pfam02601
Location:322 → 400

Exonuc_VII_L; Exonuclease VII, large subunit

pfam04871
Location:102 → 202

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

pfam06156
Location:295 → 359

DUF972; Protein of unknown function (DUF972)

cl12013
Location:237 → 350

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature