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Zfp469 zinc finger protein 469 [ Mus musculus (house mouse) ]

Gene ID: 195209, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp469provided by MGI
Official Full Name
zinc finger protein 469provided by MGI
Primary source
MGI:MGI:2684868
See related
Ensembl:ENSMUSG00000043903 AllianceGenome:MGI:2684868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm22
Summary
Is expressed in several structures, including craniocervical region bone; sensory organ; skeleton; tarsus; and urinary system. Used to study brittle cornea syndrome 1. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 1.6), limb E14.5 (RPKM 1.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 70.85 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122770009..122999389)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122043123..122272650)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene BTG3 associated nuclear protein Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene microRNA 7237 Neighboring gene STARR-seq mESC enhancer starr_22941 Neighboring gene STARR-seq mESC enhancer starr_22942 Neighboring gene predicted gene, 34413 Neighboring gene predicted gene, 39268 Neighboring gene Zfpm1R1 and Zfpm1R2 erythroid cis-regulatory modules Neighboring gene STARR-positive B cell enhancer ABC_E8268 Neighboring gene Zfpm1R7 and Zfpm1R21 erythroid cis-regulatory modules Neighboring gene STARR-seq mESC enhancer starr_22944 Neighboring gene STARR-positive B cell enhancer ABC_E2277 Neighboring gene STARR-positive B cell enhancer ABC_E6695 Neighboring gene Zfpm1R13 and Zfpm1R24 erythroid cis-regulatory modules Neighboring gene STARR-positive B cell enhancer ABC_E6696 Neighboring gene Zfpm1R19 and Zfpm1R14 erythroid cis-regulatory modules Neighboring gene predicted gene, 39269 Neighboring gene STARR-seq mESC enhancer starr_22945 Neighboring gene Zfpm1R6 erythroid cis-regulatory module Neighboring gene zinc finger protein, multitype 1 Neighboring gene Zfpm1R18 erythroid cis-regulatory module Neighboring gene Zfpm1R10 erythroid cis-regulatory module Neighboring gene Zfpm1R12 erythroid cis-regulatory module Neighboring gene predicted gene, 46056

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Two primate-specific small non-protein-coding RNAs in transgenic mice: neuronal expression, subcellular localization and binding partners. Khanam T, et al. Nucleic Acids Res, 2007. PMID 17175535, Free PMC Article
  2. A mouse model of brittle cornea syndrome caused by mutation in Zfp469. Stanton CM, et al. Dis Model Mech, 2021 Sep 1. PMID 34368841, Free PMC Article
  3. Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling. Aboudehen K, et al. J Biol Chem, 2018 Jun 15. PMID 29716997, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mouse model of brittle cornea syndrome caused by mutation in Zfp469.
    Title: A mouse model of brittle cornea syndrome caused by mutation in Zfp469.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix constituent secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression involved in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within substantia propria of cornea development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
zinc finger protein 469

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362883.2 → NP_001349812.1  zinc finger protein 469

    Status: VALIDATED

    Source sequence(s)
    AC121976
    Consensus CDS
    CCDS90472.1
    UniProtKB/TrEMBL
    A0A571BEL3
    Related
    ENSMUSP00000158621.2, ENSMUST00000187142.3
    Conserved Domains (3) summary
    PHA03247
    Location:3281 → 3701
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:3171 → 3191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3171 → 3191
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    122770009..122999389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248576.4 → XP_011246878.1  zinc finger protein 469 isoform X1

    See identical proteins and their annotated locations for XP_011246878.1

    UniProtKB/TrEMBL
    A0A571BEL3
    Conserved Domains (3) summary
    PHA03247
    Location:3281 → 3701
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:3171 → 3191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3171 → 3191
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_036153837.1 → XP_036009730.1  zinc finger protein 469 isoform X1

    UniProtKB/TrEMBL
    A0A571BEL3
    Conserved Domains (3) summary
    PHA03247
    Location:3281 → 3701
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:3171 → 3191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3171 → 3191
    zf-C2H2; Zinc finger, C2H2 type

  3. XM_006531558.5 → XP_006531621.1  zinc finger protein 469 isoform X1

    See identical proteins and their annotated locations for XP_006531621.1

    UniProtKB/TrEMBL
    A0A571BEL3
    Conserved Domains (3) summary
    PHA03247
    Location:3281 → 3701
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:3171 → 3191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3171 → 3191
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein
Heading Accession and Version

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