Rasd1 RAS, dexamethasone-induced 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasd1provided by MGI
Official Full Name: RAS, dexamethasone-induced 1provided by MGI
Primary source: MGI:MGI:1270848
See related: Ensembl:ENSMUSG00000049892 AllianceGenome:MGI:1270848
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dexras1
Summary: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015]
Expression: Biased expression in genital fat pad adult (RPKM 37.6), ovary adult (RPKM 26.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 37.81 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (59854007..59855770, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (59963181..59964944, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-375 acts as a novel factor modulating pituitary prolactin synthesis through Rasd1 and Esr1.
Title: miR-375 acts as a novel factor modulating pituitary prolactin synthesis through Rasd1 and Esr1.
Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis.
Title: Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis.
Dexras1 is critical for maintaining the equilibrium between adipogenesis and osteogenesis upon steroid treatment.
Title: Dexras1 plays a pivotal role in maintaining the equilibrium between adipogenesis and osteogenesis.
Study reveals Dexras1 as an important stage-specific regulator of exercise-induced neurogenesis in the adult hippocampus by enhancing pro-mitogenic signaling to neural progenitor cells and modulating cell survival.
Title: Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche.
These results suggest that Dexras1 is a critical mediator of the IGF-1 signal to activate MAPK, linking glucocorticoid signaling to IGF-1 signaling in adipogenesis.
Title: Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis.
These findings suggest that RASD1 acts as a novel signaling molecule and plays an important role in regulating dynamic uterine remodeling during the estrous cycle in the uterus.
Title: Rapid expression of RASD1 is regulated by estrogen receptor-dependent intracellular signaling pathway in the mouse uterus.
This study demonstrated that provide unprecedented evidence for a selective epigenetic up-regulation of Dexras 1 gene expression in the striatum of EAE mice.
Title: Epigenetic modifications of Dexras 1 along the nNOS pathway in an animal model of multiple sclerosis.
RASD1 is a novel factor in Metaphase I-Metaphase II oocyte transition and may be involved in regulating the progression of cytokinesis and spindle formation
Title: RASD1 Knockdown Results in Failure of Oocyte Maturation.
Results suggest a potential role for Dexras1 in modulating a selective subset of psychiatric symptoms, possibly via its interaction with NMDARs and/or other disease-related binding-partners
Title: Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating.
two mechanisms of Rasd1 induction in the hypothalamus, were identified.
Title: Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236590

Rasd1 (e-PCR), detects polymorphism
- UniSTS:527516

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dexamethasone-induced Ras-related protein 1

NP_033052.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009026.5 → NP_033052.1 dexamethasone-induced Ras-related protein 1

See identical proteins and their annotated locations for NP_033052.1

Status: REVIEWED

Source sequence(s)

AK038932, AW060444

Consensus CDS

CCDS24781.1

UniProtKB/Swiss-Prot

O35626

UniProtKB/TrEMBL

Q5SWR8

Related

ENSMUSP00000051959.8, ENSMUST00000062405.8

Conserved Domains (1) summary

cd04143
Location:25 → 280

Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)