U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rac2 Rac family small GTPase 2 [ Mus musculus (house mouse) ]

Gene ID: 19354, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Rac2provided by MGI
Official Full Name
Rac family small GTPase 2provided by MGI
Primary source
MGI:MGI:97846
See related
Ensembl:ENSMUSG00000033220 AllianceGenome:MGI:97846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTPase activity and protein kinase regulator activity. Involved in positive regulation of lamellipodium assembly; regulation of leukocyte activation; and regulation of leukocyte chemotaxis. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; actin cytoskeleton organization; and cell projection assembly. Located in cytoplasm; membrane; and nuclear envelope. Is expressed in heart. Used to study immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 361.0), thymus adult (RPKM 337.1) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rac2 in Genome Data Viewer
Location:
15 E1; 15 37.57 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78443369..78456983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78559169..78572783, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene somatostatin receptor 3 Neighboring gene STARR-seq mESC enhancer starr_39149 Neighboring gene L antigen family, member 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78394443-78394712 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78402050-78402237 Neighboring gene STARR-positive B cell enhancer ABC_E11809 Neighboring gene predicted gene, 36738 Neighboring gene STARR-positive B cell enhancer ABC_E4140 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78412317-78412601 Neighboring gene STARR-positive B cell enhancer ABC_E9915 Neighboring gene STARR-positive B cell enhancer ABC_E11597 Neighboring gene STARR-positive B cell enhancer ABC_E2444 Neighboring gene STARR-positive B cell enhancer ABC_E10866 Neighboring gene predicted gene, 52186 Neighboring gene cytohesin 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis. Arizmendi N, et al. Respir Res, 2014 Jun 27. PMID 24970330, Free PMC Article
  2. The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues. Johnsson AE, et al. Cell Rep, 2014 Mar 27. PMID 24630994, Free PMC Article
  3. Osteoclasts lacking Rac2 have defective chemotaxis and resorptive activity. Itokowa T, et al. Calcif Tissue Int, 2011 Jan. PMID 21110188, Free PMC Article
  4. Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. Sengupta A, et al. Blood, 2010 Jul 8. PMID 20407032, Free PMC Article
  5. Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury. Dooley JL, et al. Am J Physiol Lung Cell Mol Physiol, 2009 Dec. PMID 19801448, Free PMC Article

See all (151) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rac2 regulates immune complex-mediated granule polarization and exocytosis in neutrophils.
    Title: Rac2 regulates immune complex-mediated granule polarization and exocytosis in neutrophils.
  2. HIF-1alpha promotes paraquat induced acute lung injury and implicates a role NF-kappaB and Rac2 activity.
    Title: HIF-1α promotes paraquat induced acute lung injury and implicates a role NF-κB and Rac2 activity.
  3. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
    Title: Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
  4. Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing Rac2 Is Required for Efferocytosis Internalization and Reduction of Atherosclerosis Development.
    Title: Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing Rac2 Is Required for Efferocytosis Internalization and Reduction of Atherosclerosis Development.
  5. Calcium/calmodulin-dependent regulation of Rac GTPases and Akt in histamine-induced chemotaxis of mast cells.
    Title: Calcium/calmodulin-dependent regulation of Rac GTPases and Akt in histamine-induced chemotaxis of mast cells.
  6. Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice.
    Title: Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice.
  7. Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome.
    Title: Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome.
  8. Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
    Title: Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
  9. HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
    Title: HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
  10. Rac1 and Rac2 have distinct and essential roles in intracellular signaling downstream of H4 receptor-PI3K in histamine-induced chemotaxis of mast cells
    Title: Distinct Roles of Small GTPases Rac1 and Rac2 in Histamine H(4) Receptor-Mediated Chemotaxis of Mast Cells.
Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in bone resorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell projection assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within erythrocyte enucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lymphocyte aggregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of mast cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of mast cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mast cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mast cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mast cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neutrophil migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of respiratory burst ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ras-related C3 botulinum toxin substrate 2
Names
EN-7 protein
RAS-related C3 botulinum substrate 2
p21-Rac2
protein EN-7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009008.3 → NP_033034.1  ras-related C3 botulinum toxin substrate 2

    See identical proteins and their annotated locations for NP_033034.1

    Status: VALIDATED

    Source sequence(s)
    AK171321, AL590144
    Consensus CDS
    CCDS27619.1
    UniProtKB/Swiss-Prot
    Q05144, Q3TBC4, Q9D8X9
    UniProtKB/TrEMBL
    Q8BPG5, Q9D859
    Related
    ENSMUSP00000036384.7, ENSMUST00000043214.8
    Conserved Domains (1) summary
    cd01871
    Location:3 → 176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78443369..78456983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05144.1 GenPept UniProtKB/Swiss-Prot:Q05144

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous