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Rab33a RAB33A, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19337, updated on 11-Apr-2024

Summary

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Official Symbol
Rab33aprovided by MGI
Official Full Name
RAB33A, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:109493
See related
Ensembl:ENSMUSG00000031104 AllianceGenome:MGI:109493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rabs10
Summary
This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be expressed in lymphocytes and in regions of the mouse brain, specifically the cortex, hippocampus and also the olfactory bulb. The ortholog of this protein in rat has been characterized and may participate in anterograde trafficking of synaptophysin-positive vesicles to the plasma membrane. [provided by RefSeq, Jun 2013]
Expression
Biased expression in CNS E18 (RPKM 32.4), CNS E14 (RPKM 23.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X 25.68 cM; X A5
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47602540..47619112)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48513663..48530240)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45782874-45783027 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45786781-45786934 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 1 Neighboring gene STARR-seq mESC enhancer starr_47122 Neighboring gene zinc finger protein 280C Neighboring gene solute carrier family 25 (mitochondrial carrier, brain), member 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab33A: characterization, expression, and suppression by epigenetic modification. Cheng E, et al. J Invest Dermatol, 2006 Oct. PMID 16810302
  2. Structure and expression of the mouse S10 gene. Zheng JY, et al. Biochim Biophys Acta, 1997 Mar 20. PMID 9116044
  3. Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth. Nakazawa H, et al. J Neurosci, 2012 Sep 12. PMID 22972995, Free PMC Article
  4. Molecular cloning of a cDNA encoding a novel small GTP-binding protein. Koda T, et al. FEBS Lett, 1993 Aug 9. PMID 7688322
  5. A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. Zheng JY, et al. J Cell Sci, 1998 Apr. PMID 9512502

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC129488, MGC129489

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-33A
Names
RAB33A, member of RAS oncogene family
small GTP-binding protein S10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425935.1 → NP_001412864.1  ras-related protein Rab-33A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL669901

  2. NM_001425936.1 → NP_001412865.1  ras-related protein Rab-33A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL669901

  3. NM_011228.3 → NP_035358.1  ras-related protein Rab-33A isoform 1

    See identical proteins and their annotated locations for NP_035358.1

    Status: REVIEWED

    Source sequence(s)
    AL669901
    Consensus CDS
    CCDS30110.1
    UniProtKB/Swiss-Prot
    P97950
    UniProtKB/TrEMBL
    Q3SXA7
    Related
    ENSMUSP00000033430.3, ENSMUST00000033430.3
    Conserved Domains (1) summary
    cd04115
    Location:35 → 204
    Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    47602540..47619112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251262.2 → XP_030107122.1  ras-related protein Rab-33A isoform X2

    UniProtKB/Swiss-Prot
    P97950
    UniProtKB/TrEMBL
    Q3SXA7
    Conserved Domains (1) summary
    cd04115
    Location:35 → 204
    Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

  2. XM_036161859.1 → XP_036017752.1  ras-related protein Rab-33A isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:108 → 225
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_036161860.1 → XP_036017753.1  ras-related protein Rab-33A isoform X2

    UniProtKB/Swiss-Prot
    P97950
    UniProtKB/TrEMBL
    Q3SXA7
    Conserved Domains (1) summary
    cd04115
    Location:35 → 204
    Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

  4. XM_036161858.1 → XP_036017751.1  ras-related protein Rab-33A isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:108 → 225
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_030251263.1 → XP_030107123.1  ras-related protein Rab-33A isoform X4

    Conserved Domains (1) summary
    cl38936
    Location:1 → 103
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_036161861.1 → XP_036017754.1  ras-related protein Rab-33A isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:2 → 119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97950.1 GenPept UniProtKB/Swiss-Prot:P97950

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