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Rab19 RAB19, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19331, updated on 11-Apr-2024

Summary

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Official Symbol
Rab19provided by MGI
Official Full Name
RAB19, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:103292
See related
Ensembl:ENSMUSG00000029923 AllianceGenome:MGI:103292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Predicted to be located in plasma membrane. Predicted to be active in endomembrane system. Orthologous to human RAB19 (RAB19, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 7.5), thymus adult (RPKM 3.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 18.16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39357645..39367600)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39380709..39390666)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53067 Neighboring gene predicted gene, 26008 Neighboring gene STARR-seq mESC enhancer starr_15634 Neighboring gene STARR-seq mESC enhancer starr_15635 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 3 Neighboring gene STARR-seq mESC enhancer starr_15639 Neighboring gene STARR-positive B cell enhancer ABC_E4822 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:39329756-39330023 Neighboring gene makorin, ring finger protein, 1 Neighboring gene STARR-seq mESC enhancer starr_15648 Neighboring gene predicted gene 10244 Neighboring gene predicted gene, 25402

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of a murine cDNA clone encoding Rab19, a novel tissue-specific small GTPase. Lütcke A, et al. Gene, 1995 Apr 3. PMID 7721101
  2. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Chavrier P, et al. Gene, 1992 Mar 15. PMID 1555775
  3. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
  4. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082
  5. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12578829

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
    Title: WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011226.2 → NP_035356.1  ras-related protein Rab-19

    See identical proteins and their annotated locations for NP_035356.1

    Status: VALIDATED

    Source sequence(s)
    BC032936, BQ562779
    Consensus CDS
    CCDS20021.1
    UniProtKB/Swiss-Prot
    O35697, P35294, Q6GTV2
    Related
    ENSMUSP00000031986.5, ENSMUST00000031986.5
    Conserved Domains (2) summary
    cd01864
    Location:15 → 179
    Rab19; Rab GTPase family 19 (Rab19)
    smart00175
    Location:18 → 182
    RAB; Rab subfamily of small GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    39357645..39367600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505760.3 → XP_006505823.1  ras-related protein Rab-19 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:42 → 153
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35294.3 GenPept UniProtKB/Swiss-Prot:P35294

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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