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Pvt1 Pvt1 oncogene [ Mus musculus (house mouse) ]

Gene ID: 19296, updated on 5-Mar-2024

Summary

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Official Symbol
Pvt1provided by MGI
Official Full Name
Pvt1 oncogeneprovided by MGI
Primary source
MGI:MGI:97824
See related
Ensembl:ENSMUSG00000097039 AllianceGenome:MGI:97824
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mis-1; Pvt-1; Mlvi-1; Ayu21-84Imeg; Gt(pU21)84Imeg
Summary
This gene produces a long non-coding RNA that has been identified as a candidate oncogene. In humans, increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Consistently, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. In mouse, this gene has also been found to be a potential regulator of cardiac hypertrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in cortex adult (RPKM 2.0), bladder adult (RPKM 1.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Pvt1 in Genome Data Viewer
Location:
15 D1; 15 26.24 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (61909835..62132064)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (62037986..62260215)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38814 Neighboring gene STARR-seq mESC enhancer starr_38815 Neighboring gene origin of replication upstream of Myc Neighboring gene STARR-seq mESC enhancer starr_38818 Neighboring gene STARR-seq mESC enhancer starr_38819 Neighboring gene predicted gene, 18788 Neighboring gene STARR-seq mESC enhancer starr_38820 Neighboring gene myelocytomatosis oncogene Neighboring gene STARR-seq mESC enhancer starr_38824 Neighboring gene predicted gene, 53890 Neighboring gene STARR-positive B cell enhancer ABC_E5482 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:62001280-62001493 Neighboring gene STARR-positive B cell enhancer ABC_E7373 Neighboring gene STARR-positive B cell enhancer mm9_chr15:62013150-62013450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:62044000-62044201 Neighboring gene macroH2A.3 histone Neighboring gene STARR-seq mESC enhancer starr_38830 Neighboring gene STARR-positive B cell enhancer mm9_chr15:62189952-62190252 Neighboring gene STARR-seq mESC enhancer starr_38831 Neighboring gene STARR-seq mESC enhancer starr_38832 Neighboring gene STARR-seq mESC enhancer starr_38833 Neighboring gene STARR-seq mESC enhancer starr_38834 Neighboring gene predicted gene, 41333 Neighboring gene STARR-seq mESC enhancer starr_38835 Neighboring gene predicted gene, 22521

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth. Eckberg K, et al. Am J Physiol Renal Physiol, 2022 Sep 1. PMID 35862648, Free PMC Article
  2. Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation. Zhang H, et al. Mol Neurobiol, 2021 Nov. PMID 34436749
  3. N(6) -methyladenosine modification of lncRNA Pvt1 governs epidermal stemness. Lee J, et al. EMBO J, 2021 Apr 15. PMID 33729590, Free PMC Article
  4. Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone. Liu B, et al. Mol Med Rep, 2020 Oct. PMID 32945428, Free PMC Article
  5. Long Noncoding RNA from PVT1 Exon 9 Is Overexpressed in Prostate Cancer and Induces Malignant Transformation and Castration Resistance in Prostate Epithelial Cells. Pal G, et al. Genes (Basel), 2019 Nov 22. PMID 31766781, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth.
    Title: Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth.
  2. Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation.
    Title: Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation.
  3. Circular RNA PVT1 silencing prevents ischemia-reperfusion injury in rat by targeting microRNA-125b and microRNA-200a.
    Title: Circular RNA PVT1 silencing prevents ischemia-reperfusion injury in rat by targeting microRNA-125b and microRNA-200a.
  4. Knockdown of lncRNA PVT1 attenuated macrophage M1 polarization and relieved sepsis induced myocardial injury via miR-29a/HMGB1 axis.
    Title: Knockdown of lncRNA PVT1 attenuated macrophage M1 polarization and relieved sepsis induced myocardial injury via miR-29a/HMGB1 axis.
  5. ZFP36L2 regulates myocardial ischemia/reperfusion injury and attenuates mitochondrial fusion and fission by LncRNA PVT1.
    Title: ZFP36L2 regulates myocardial ischemia/reperfusion injury and attenuates mitochondrial fusion and fission by LncRNA PVT1.
  6. N(6) -methyladenosine modification of lncRNA Pvt1 governs epidermal stemness.
    Title: N(6) -methyladenosine modification of lncRNA Pvt1 governs epidermal stemness.
  7. LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF-beta/SMAD4 signaling.
    Title: LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF-β/SMAD4 signaling.
  8. lncRNA PVT1 modulates NLRP3mediated pyroptosis in septic acute kidney injury by targeting miR20a5p.
    Title: lncRNA PVT1 modulates NLRP3‑mediated pyroptosis in septic acute kidney injury by targeting miR‑20a‑5p.
  9. Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone.
    Title: Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone.
  10. The findings demonstrate that Pvt1b acts at the intersection of the p53 and Myc transcriptional networks to reinforce the anti-proliferative activities of p53.
    Title: p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Other Names

  • plasmacytoma variant translocation 1

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003368.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC126552, AK010708, AK043790, AK169445, BY473510
    Related
    ENSMUST00000243276.1

  2. NR_132746.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon and lacks two internal exons compared to variant 1.
    Source sequence(s)
    AC126552, AK010708, AK020628, AK169445, BY473510
    Related
    ENSMUST00000181657.9

  3. NR_132747.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks internal exons and uses an alternate 3'-terminal exon compared to variant 1.
    Source sequence(s)
    AC126552, AI428930, AK013704, AK043252, AK043790
    Related
    ENSMUST00000243734.1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    61909835..62132064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011222.1: Suppressed sequence

    Description
    NM_011222.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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