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Ptprg protein tyrosine phosphatase receptor type G [ Mus musculus (house mouse) ]

Gene ID: 19270, updated on 21-Apr-2024

Summary

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Official Symbol
Ptprgprovided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Gprovided by MGI
Primary source
MGI:MGI:97814
See related
Ensembl:ENSMUSG00000121513 AllianceGenome:MGI:97814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPTPgamma; 5430405N12Rik
Summary
Predicted to enable identical protein binding activity and protein tyrosine phosphatase activity. Acts upstream of or within toxin transport. Predicted to be located in extracellular space. Is expressed in several structures, including central nervous system and retina. Orthologous to human PTPRG (protein tyrosine phosphatase receptor type G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 13.7), ovary adult (RPKM 13.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A1; 14 6.33 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (10227722..10916341, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (11553440..12242041)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35954 Neighboring gene predicted gene, 24578 Neighboring gene centrosomal protein 15 Neighboring gene STARR-seq mESC enhancer starr_35952 Neighboring gene STARR-seq mESC enhancer starr_35951 Neighboring gene predicted gene, 53822 Neighboring gene STARR-seq mESC enhancer starr_35947 Neighboring gene STARR-seq mESC enhancer starr_35940 Neighboring gene STARR-seq mESC enhancer starr_35939 Neighboring gene STARR-seq mESC enhancer starr_35937 Neighboring gene STARR-seq mESC enhancer starr_35926 Neighboring gene STARR-seq mESC enhancer starr_35924 Neighboring gene predicted gene, 52128 Neighboring gene STARR-seq mESC enhancer starr_35922 Neighboring gene STARR-seq mESC enhancer starr_35921 Neighboring gene STARR-seq mESC enhancer starr_35920 Neighboring gene STARR-seq mESC enhancer starr_35919 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35918 Neighboring gene STARR-seq mESC enhancer starr_35917 Neighboring gene predicted gene, 25466

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance. Brenachot X, et al. Nat Commun, 2017 Nov 28. PMID 29180649, Free PMC Article
  2. Extracellular HCO3- is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ. Boedtkjer E, et al. J Cereb Blood Flow Metab, 2016 May. PMID 26661205, Free PMC Article
  3. Distribution of different isoforms of receptor protein tyrosine phosphatase γ (Ptprg-RPTP γ) in adult mouse brain: upregulation during neuroinflammation. Lorenzetto E, et al. Brain Struct Funct, 2014 May. PMID 23536318
  4. Characterization of PTPRG in knockdown and phosphatase-inactive mutant mice and substrate trapping analysis of PTPRG in mammalian cells. Zhang W, et al. PLoS One, 2012. PMID 23029056, Free PMC Article
  5. Receptor protein tyrosine phosphatase gamma, Ptp gamma, regulates hematopoietic differentiation. Sorio C, et al. Blood, 1997 Jul 1. PMID 9207437

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPRG is an ischemia risk locus essential for HCO3(-)-dependent regulation of endothelial function and tissue perfusion.
    Title: PTPRG is an ischemia risk locus essential for HCO(3)(-)-dependent regulation of endothelial function and tissue perfusion.
  2. vasoconstriction promoted through RPTPgamma-dependent changes in VSMC Ca(2+)-sensitivity
    Title: Extracellular HCO3- is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ.
  3. Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
    Title: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
  4. Results demonstrate that PTPRG plasmatic form (sPTPRG) represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage.
    Title: Identification of protein tyrosine phosphatase receptor gamma extracellular domain (sPTPRG) as a natural soluble protein in plasma.
  5. confirm previous findings and enrich the current knowledge of RPTPgamma distribution in the CNS, highlighting a role of RPTPgamma during neuroinflammation processes
    Title: Distribution of different isoforms of receptor protein tyrosine phosphatase γ (Ptprg-RPTP γ) in adult mouse brain: upregulation during neuroinflammation.
  6. RPTPgamma is expressed in a variety of tissues during embryogenesis.
    Title: Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase gamma
Names
Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma)
R-PTP-gamma
NP_001334522.1
NP_033007.2
XP_006518019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347593.1 → NP_001334522.1  receptor-type tyrosine-protein phosphatase gamma isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is much shorter than isoform 1.
    Source sequence(s)
    AC154682, AK144283, CF724833
    Consensus CDS
    CCDS84092.1
    UniProtKB/TrEMBL
    Q3UND4

  2. NM_008981.3 → NP_033007.2  receptor-type tyrosine-protein phosphatase gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_033007.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154682, AK134814, BC079595, L09562
    Consensus CDS
    CCDS26816.1
    UniProtKB/Swiss-Prot
    Q05909
    UniProtKB/TrEMBL
    A0A991ELE1
    Related
    ENSMUSP00000159543.1, ENSMUST00000248537.1
    Conserved Domains (5) summary
    PLN02179
    Location:17 → 272
    PLN02179; carbonic anhydrase
    smart00194
    Location:844 → 1115
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:873 → 1115
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:348 → 438
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd03122
    Location:67 → 319
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    10227722..10916341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517956.5 → XP_006518019.1  receptor-type tyrosine-protein phosphatase gamma isoform X1

    UniProtKB/Swiss-Prot
    Q05909
    Conserved Domains (5) summary
    PRK12495
    Location:613 → 689
    PRK12495; hypothetical protein; Provisional
    cd00063
    Location:348 → 438
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd03122
    Location:67 → 319
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    cd17667
    Location:816 → 1089
    R-PTPc-G-1; catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1
    cd17670
    Location:1173 → 1377
    R-PTP-G-2; PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05909.1 GenPept UniProtKB/Swiss-Prot:Q05909

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