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Zfp286 zinc finger protein 286 [ Mus musculus (house mouse) ]

Gene ID: 192651, updated on 30-Apr-2024

Summary

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Official Symbol
Zfp286provided by MGI
Official Full Name
zinc finger protein 286provided by MGI
Primary source
MGI:MGI:2384758
See related
Ensembl:ENSMUSG00000047342 AllianceGenome:MGI:2384758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Orthologous to several human genes including ZNF286A (zinc finger protein 286A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 2.6), CNS E18 (RPKM 2.5) and 12 other tissues See more
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Genomic context

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Location:
11 B2; 11 38.68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62640003..62680385, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62751951..62789506, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 287 Neighboring gene nuclear encoded tRNA trytophan 8 (anticodon CCA) Neighboring gene WD repeat and SOCS box-containing 2, pseudogene Neighboring gene zinc finger protein 286, opposite strand Neighboring gene predicted gene, 24151 Neighboring gene tripartite motif-containing 16 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene F-box and WD-40 domain protein 10 Neighboring gene STARR-seq mESC enhancer starr_29719

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC39058

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 286A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364096.1 → NP_001351025.1  zinc finger protein 286A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627097, BB627774
    Conserved Domains (5) summary
    smart00349
    Location:1 → 62
    KRAB; krueppel associated box
    COG5048
    Location:301 → 461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220 → 242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001364097.1 → NP_001351026.1  zinc finger protein 286A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627097
    Conserved Domains (5) summary
    smart00349
    Location:1 → 62
    KRAB; krueppel associated box
    COG5048
    Location:301 → 461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220 → 242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001364098.1 → NP_001351027.1  zinc finger protein 286A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627097
    Consensus CDS
    CCDS88169.1
    UniProtKB/TrEMBL
    Q5SVS7
    Related
    ENSMUSP00000104345.2, ENSMUST00000108705.8
    Conserved Domains (1) summary
    smart00349
    Location:50 → 111
    KRAB; krueppel associated box

  4. NM_001364100.1 → NP_001351029.1  zinc finger protein 286A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627097, BC038632
    Related
    ENSMUST00000145474.8
    Conserved Domains (1) summary
    smart00349
    Location:50 → 111
    KRAB; krueppel associated box

  5. NM_138949.4 → NP_620399.3  zinc finger protein 286A isoform 1

    See identical proteins and their annotated locations for NP_620399.3

    Status: VALIDATED

    Source sequence(s)
    AK031547, AL627097, CJ164719
    Consensus CDS
    CCDS24831.1
    UniProtKB/TrEMBL
    Q8C0E6
    Related
    ENSMUSP00000055517.7, ENSMUST00000054654.13
    Conserved Domains (6) summary
    smart00349
    Location:50 → 111
    KRAB; krueppel associated box
    COG5048
    Location:350 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:352 → 374
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:50 → 85
    KRAB; KRAB box
    pfam13465
    Location:422 → 447
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62640003..62680385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245695.2 → XP_030101555.1  zinc finger protein 286A isoform X7

    UniProtKB/TrEMBL
    A0A140LIZ8
    Related
    ENSMUSP00000147022.2, ENSMUST00000207597.2
    Conserved Domains (1) summary
    smart00349
    Location:50 → 111
    KRAB; krueppel associated box

  2. XM_030245694.2 → XP_030101554.1  zinc finger protein 286A isoform X6

    Conserved Domains (1) summary
    smart00349
    Location:107 → 168
    KRAB; krueppel associated box

  3. XM_017314347.2 → XP_017169836.1  zinc finger protein 286A isoform X5

    Conserved Domains (4) summary
    COG5048
    Location:234 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:153 → 175
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:140 → 164
    zf-H2C2_2; Zinc-finger double domain

  4. XM_030245693.1 → XP_030101553.1  zinc finger protein 286A isoform X5

    Conserved Domains (4) summary
    COG5048
    Location:234 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:153 → 175
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:140 → 164
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011248814.1 → XP_011247116.1  zinc finger protein 286A isoform X4

    See identical proteins and their annotated locations for XP_011247116.1

    UniProtKB/TrEMBL
    Q8R0E0
    Conserved Domains (4) summary
    COG5048
    Location:243 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:275 → 295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:162 → 184
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:149 → 173
    zf-H2C2_2; Zinc-finger double domain

  6. XM_030245692.2 → XP_030101552.1  zinc finger protein 286A isoform X4

    UniProtKB/TrEMBL
    Q8R0E0
    Conserved Domains (4) summary
    COG5048
    Location:243 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:275 → 295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:162 → 184
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:149 → 173
    zf-H2C2_2; Zinc-finger double domain

  7. XM_030245691.2 → XP_030101551.1  zinc finger protein 286A isoform X4

    UniProtKB/TrEMBL
    Q8R0E0
    Conserved Domains (4) summary
    COG5048
    Location:243 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:275 → 295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:162 → 184
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:149 → 173
    zf-H2C2_2; Zinc-finger double domain

  8. XM_030245690.2 → XP_030101550.1  zinc finger protein 286A isoform X4

    UniProtKB/TrEMBL
    Q8R0E0
    Conserved Domains (4) summary
    COG5048
    Location:243 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:275 → 295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:162 → 184
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:149 → 173
    zf-H2C2_2; Zinc-finger double domain

  9. XM_011248815.3 → XP_011247117.1  zinc finger protein 286A isoform X8

    Conserved Domains (4) summary
    COG5048
    Location:316 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:348 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:235 → 257
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:222 → 246
    zf-H2C2_2; Zinc-finger double domain

  10. XM_011248812.3 → XP_011247114.1  zinc finger protein 286A isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:1 → 62
    KRAB; krueppel associated box
    COG5048
    Location:301 → 461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220 → 242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain

  11. XM_036156440.1 → XP_036012333.1  zinc finger protein 286A isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:340 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:259 → 281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:246 → 270
    zf-H2C2_2; Zinc-finger double domain

  12. XM_006532543.3 → XP_006532606.3  zinc finger protein 286A isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:370 → 530
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:289 → 311
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:276 → 300
    zf-H2C2_2; Zinc-finger double domain

  13. XM_011248811.4 → XP_011247113.2  zinc finger protein 286A isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:1 → 62
    KRAB; krueppel associated box
    COG5048
    Location:301 → 461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220 → 242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
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