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Edem1 ER degradation enhancer, mannosidase alpha-like 1 [ Mus musculus (house mouse) ]

Gene ID: 192193, updated on 11-Apr-2024

Summary

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Official Symbol
Edem1provided by MGI
Official Full Name
ER degradation enhancer, mannosidase alpha-like 1provided by MGI
Primary source
MGI:MGI:2180139
See related
Ensembl:ENSMUSG00000030104 AllianceGenome:MGI:2180139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EDEM; mKIAA0212; A130059K23Rik
Summary
Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in positive regulation of retrograde protein transport, ER to cytosol and trimming of terminal mannose on C branch. Acts upstream of or within ubiquitin-dependent ERAD pathway. Is integral component of endoplasmic reticulum membrane. Is expressed in embryo and liver. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 71.9), liver adult (RPKM 21.5) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E2; 6 49.87 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (108800984..108836317)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (108824045..108859356)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1705 Neighboring gene STARR-seq mESC enhancer starr_16978 Neighboring gene predicted gene, 35359 Neighboring gene STARR-positive B cell enhancer ABC_E8121 Neighboring gene STARR-positive B cell enhancer ABC_E6466 Neighboring gene ADP-ribosylation factor-like 8B Neighboring gene predicted gene, 51409 Neighboring gene predicted gene, 35417 Neighboring gene STARR-positive B cell enhancer mm9_chr6:108775076-108775377 Neighboring gene STARR-positive B cell enhancer ABC_E3668 Neighboring gene STARR-positive B cell enhancer ABC_E3669 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:108785919-108786120 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:108786185-108786368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:108789575-108789776 Neighboring gene predicted pseudogene 6749 Neighboring gene predicted gene, 53302

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol. Slominska-Wojewodzka M, et al. Mol Biol Cell, 2006 Apr. PMID 16452630, Free PMC Article
  2. EDEM contributes to maintenance of protein folding efficiency and secretory capacity. Eriksson KK, et al. J Biol Chem, 2004 Oct 22. PMID 15308654
  3. Cleavage and degradation of EDEM1 promotes coxsackievirus B3 replication via ATF6a-mediated unfolded protein response signalling. Zhang HM, et al. Cell Microbiol, 2020 Jul. PMID 32083795
  4. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes. Sharma M, et al. Autophagy, 2014 Sep. PMID 25046112, Free PMC Article
  5. EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans. Hosokawa N, et al. Glycobiology, 2010 May. PMID 20065073

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cleavage and degradation of EDEM1 promotes coxsackievirus B3 replication via ATF6a-mediated unfolded protein response signalling.
    Title: Cleavage and degradation of EDEM1 promotes coxsackievirus B3 replication via ATF6a-mediated unfolded protein response signalling.
  2. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes
    Title: Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes.
  3. Data suggest Edem1/Edem2 participate in ricin translocation; overexpression of Edem2, in contrast to Edem1, promotes ricin subunit A transport from endoplasmic reticulum (ER) to cytosol; transport of ricin P250A mutant is Edem1/Edem2-independent.
    Title: The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol.
  4. analysis of a shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins
    Title: A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins.
  5. Cells with defective EDEM1 turnover contain unphysiologically high levels of EDEM1, show enhanced ER associated degradation activity and are characterized by impaired capacity to efficiently complete maturation of model glycopolypeptides.
    Title: Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities.
  6. EDEM is involved in retrotranslocation of ricin from the ER to the cytosol.
    Title: EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol.
  7. role of the lectins Htm1p/EDEM in the degradation process of CFTR
    Title: Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast.
  8. EDEM has a role in maintenance of protein folding efficiency and secretory capacity
    Title: EDEM contributes to maintenance of protein folding efficiency and secretory capacity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0212

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables alpha-mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ERAD pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum mannose trimming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mannose trimming involved in glycoprotein ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of retrograde protein transport, ER to cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to ER ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in trimming of terminal mannose on C branch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum quality control compartment ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ER degradation-enhancing alpha-mannosidase-like protein 1
Names
ER degradation ER degradation enhancer, mannosidase alpha-like 1
ER degradation-enhancing alpha-mannosidase-like 1
NP_619618.1
XP_006505809.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138677.2 → NP_619618.1  ER degradation-enhancing alpha-mannosidase-like protein 1

    See identical proteins and their annotated locations for NP_619618.1

    Status: VALIDATED

    Source sequence(s)
    AB042828, AC132443, BB619976
    Consensus CDS
    CCDS20402.1
    UniProtKB/Swiss-Prot
    Q8CFM1, Q925U4
    UniProtKB/TrEMBL
    Q3U9S2
    Related
    ENSMUSP00000086565.4, ENSMUST00000089162.5
    Conserved Domains (1) summary
    pfam01532
    Location:132 → 577
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    108800984..108836317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505746.5 → XP_006505809.1  ER degradation-enhancing alpha-mannosidase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505809.1

    UniProtKB/TrEMBL
    Q8BYV2
    Conserved Domains (1) summary
    pfam01532
    Location:1 → 387
    Glyco_hydro_47; Glycosyl hydrolase family 47

RNA

  1. XR_001785109.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925U4.1 GenPept UniProtKB/Swiss-Prot:Q925U4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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