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Tmprss15 transmembrane protease, serine 15 [ Mus musculus (house mouse) ]

Gene ID: 19146, updated on 21-Apr-2024

Summary

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Official Symbol
Tmprss15provided by MGI
Official Full Name
transmembrane protease, serine 15provided by MGI
Primary source
MGI:MGI:1197523
See related
Ensembl:ENSMUSG00000022857 AllianceGenome:MGI:1197523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Entk; Prss7
Summary
This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Expression
Biased expression in small intestine adult (RPKM 1.8) and duodenum adult (RPKM 0.4) See more
Orthologs
human all
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Genomic context

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Location:
16 C3.1- C3.2; 16 45.41 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78749896..78887988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78953008..79091097, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930570E03 gene Neighboring gene STARR-seq mESC enhancer starr_41312 Neighboring gene STARR-seq mESC enhancer starr_41313 Neighboring gene STARR-seq mESC enhancer starr_41314 Neighboring gene STARR-seq mESC enhancer starr_41315 Neighboring gene chondrolectin Neighboring gene STARR-seq mESC enhancer starr_41316 Neighboring gene STARR-seq mESC enhancer starr_41317 Neighboring gene STARR-seq mESC enhancer starr_41318 Neighboring gene STARR-seq mESC enhancer starr_41319 Neighboring gene aldo-keto reductase family 1, member D1 pseudogene Neighboring gene ribosomal protein S19, pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression profiling in a mouse model for African trypanosomiasis. Kierstein S, et al. Genes Immun, 2006 Dec. PMID 17066074, Free PMC Article
  2. Two-dimensional gel analysis of zymogen-activating factors in the small intestine of the mouse. Isobe M, et al. J Exp Zool, 1984 Jul. PMID 6381640
  3. Electrophoretic analysis of pancreatic proteases and zymogen-activating factors in the mouse. Isobe M, et al. J Exp Zool, 1984 Jun. PMID 6379096
  4. Development of enteropeptidase activity in mouse small intestine: influence of hormones. Arsenault P, et al. Can J Physiol Pharmacol, 1985 May. PMID 3899338
  5. Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development. Yuan X, et al. Am J Physiol, 1998 Feb. PMID 9486188

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enteropeptidase could inhibit osteoclastogenesis in vitro through the cleavage of RANK.
    Title: Inhibition effect of enteropeptidase on RANKL-RANK signalling by cleavage of RANK.
  2. peptide sequencing of amino terminus of light chain of cow enterokinase, identifying the cleavage site
    Title: The amino-terminal sequence of the catalytic subunit of bovine enterokinase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
enteropeptidase
Names
enterokinase
protease, serine, 7 (enterokinase)
NP_032967.1
NP_849186.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008941.4 → NP_032967.1  enteropeptidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_032967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC112257, AC161815
    Consensus CDS
    CCDS28280.1
    UniProtKB/Swiss-Prot
    P97435, Q148Y3
    Related
    ENSMUSP00000023566.5, ENSMUST00000023566.11
    Conserved Domains (11) summary
    cd06263
    Location:392 → 547
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00192
    Location:228 → 261
    LDLa; Low-density lipoprotein receptor domain class A
    smart00020
    Location:829 → 1064
    Tryp_SPc; Trypsin-like serine protease
    smart00200
    Location:53 → 154
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:723 → 816
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:688 → 722
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:830 → 1066
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:569 → 676
    CUB; CUB domain
    pfam00530
    Location:728 → 819
    SRCR; Scavenger receptor cysteine-rich domain
    pfam00629
    Location:392 → 549
    MAM; MAM domain, meprin/A5/mu
    cl00049
    Location:270 → 376
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

  2. NM_178855.5 → NP_849186.2  enteropeptidase isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC112257, AC161815
    Consensus CDS
    CCDS37380.1
    UniProtKB/TrEMBL
    E9Q6Y6
    Related
    ENSMUSP00000052034.6, ENSMUST00000060402.6
    Conserved Domains (11) summary
    cd06263
    Location:377 → 532
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00192
    Location:213 → 246
    LDLa; Low-density lipoprotein receptor domain class A
    smart00020
    Location:814 → 1049
    Tryp_SPc; Trypsin-like serine protease
    smart00200
    Location:53 → 154
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:708 → 801
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:673 → 707
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:815 → 1051
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:554 → 661
    CUB; CUB domain
    pfam00530
    Location:713 → 804
    SRCR; Scavenger receptor cysteine-rich domain
    pfam00629
    Location:377 → 534
    MAM; MAM domain, meprin/A5/mu
    cl00049
    Location:255 → 361
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    78749896..78887988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97435.1 GenPept UniProtKB/Swiss-Prot:P97435

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