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Prl8a6 prolactin family 8, subfamily a, member 6 [ Mus musculus (house mouse) ]

Gene ID: 19112, updated on 11-Apr-2024

Summary

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Official Symbol
Prl8a6provided by MGI
Official Full Name
prolactin family 8, subfamily a, member 6provided by MGI
Primary source
MGI:MGI:1332225
See related
Ensembl:ENSMUSG00000021345 AllianceGenome:MGI:1332225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ghd13; Prlpc; PLP-C1; PLP-Ca; Prlpc1; PLP-calpha
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 6.8) See more
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Genomic context

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Location:
13 A3.1; 13 12.45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27616664..27622671, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27432681..27438688, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 8, subfamily a, member 2 Neighboring gene STARR-seq mESC enhancer starr_34015 Neighboring gene prolactin family 2, subfamily b, member 1 Neighboring gene predicted gene, 40836 Neighboring gene prolactin family 8, subfamily a, member 81 Neighboring gene prolactin family8, subfamily a, member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular evolution of prolactin gene family in rodents. Li Y, et al. Yi Chuan Xue Bao, 2006 Jul. PMID 16875316
  2. A new member of the mouse prolactin (PRL)-like protein-C subfamily, PRL-like protein-C alpha: structure and expression. Dai G, et al. Endocrinology, 1998 Dec. PMID 9832456
  3. The mouse prolactin gene family locus. Wiemers DO, et al. Endocrinology, 2003 Jan. PMID 12488360
  4. Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily. Hayakawa K, et al. Mamm Genome, 2012 Jun. PMID 22193412, Free PMC Article
  5. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Tunster SJ, et al. Dev Biol, 2016 Jan 1. PMID 26476147, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolactin-8A6
Names
PRL-like protein C1
growth hormone d13
placental prolactin-like protein C1
prolactin-like protein C 1
prolactin-like protein C-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271378.1 → NP_001258307.1  prolactin-8A6 isoform a precursor

    See identical proteins and their annotated locations for NP_001258307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK005435, AK005478
    Consensus CDS
    CCDS70442.1
    UniProtKB/Swiss-Prot
    Q9DAW0, Q9DAY2, Q9Z249
    UniProtKB/TrEMBL
    A0A0M6L0X0
    Related
    ENSMUSP00000105984.3, ENSMUST00000110355.10
    Conserved Domains (1) summary
    cd10288
    Location:34 → 224
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  2. NM_001271379.1 → NP_001258308.1  prolactin-8A6 isoform c precursor

    See identical proteins and their annotated locations for NP_001258308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK005478
    Consensus CDS
    CCDS70441.1
    UniProtKB/Swiss-Prot
    Q9DAY2
    Related
    ENSMUSP00000079584.6, ENSMUST00000080762.12
    Conserved Domains (1) summary
    cl07831
    Location:34 → 189
    growth_hormone_like; Somatotropin/prolactin hormone family

  3. NM_011167.3 → NP_035297.1  prolactin-8A6 isoform b precursor

    See identical proteins and their annotated locations for NP_035297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK005435, AK005478
    Consensus CDS
    CCDS26398.1
    UniProtKB/Swiss-Prot
    Q9DAY2
    Related
    ENSMUSP00000018392.8, ENSMUST00000018392.9
    Conserved Domains (1) summary
    cd10288
    Location:33 → 223
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RNA

  1. NR_073166.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks most of the in-frame ORF found in variant 1.
    Source sequence(s)
    AK005435, AK005478, AL592443

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    27616664..27622671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAY2.1 GenPept UniProtKB/Swiss-Prot:Q9DAY2

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