Prl4a1 prolactin family 4, subfamily a, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prl4a1provided by MGI
Official Full Name: prolactin family 4, subfamily a, member 1provided by MGI
Primary source: MGI:MGI:1206587
See related: Ensembl:ENSMUSG00000005891 AllianceGenome:MGI:1206587
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ghd23; PLP-A; Prlpa
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Acts upstream of or within response to hypoxia. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in decidua; ectoplacental cone; extraembryonic component; and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward placenta adult (RPKM 133.5) See more
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Genomic context

Location:: 13 A3.1; 13 12.66 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (28200195..28207531)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (28016212..28023548)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

keratin-positive trophoblast secretion of prolactin-like protein a (Prlpa) and placental growth factor (PlGF) during decidualization are altered in the absence of keratins
Title: Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues.
PLP-A contributes to hypoxia-induced adaptations critical to hemochorial placentation and thus nutrient flow to extraembryonic and embryonic tissues.
Title: A prolactin family paralog regulates reproductive adaptations to a physiological stressor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin-4A1

Names: PRL-like protein A; growth hormone d23; placental prolactin-like protein A; prolactin-like protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011165.4 → NP_035295.1 prolactin-4A1 precursor

See identical proteins and their annotated locations for NP_035295.1

Status: VALIDATED

Source sequence(s)

AK141285, BC052218

Consensus CDS

CCDS26409.1

UniProtKB/Swiss-Prot

O35256

UniProtKB/TrEMBL

A0A0M6L0M4

Related

ENSMUSP00000021779.7, ENSMUST00000021779.8

Conserved Domains (1) summary

cd10288
Location:37 → 227

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones