Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkag1provided by MGI
Official Full Name: protein kinase, AMP-activated, gamma 1 non-catalytic subunitprovided by MGI
Primary source: MGI:MGI:108411
See related: Ensembl:ENSMUSG00000067713 AllianceGenome:MGI:108411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prkaac
Summary: Predicted to enable several functions, including adenyl ribonucleotide binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to contribute to AMP-activated protein kinase activity. Involved in import into nucleus. Located in nucleus. Is expressed in several structures, including future brain; heart; liver; and nervous system. Orthologous to human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14.5 (RPKM 48.6), liver E14 (RPKM 44.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.73 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98710678..98729354, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98812797..98831508, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production.
Title: The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production.
These results emphasize the clinical relevance of activating AMPK in the liver to combat non-alcoholic fatty liver disease.
Title: Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet.
Transgenic activation of skeletal muscle AMPKgamma1 in this model plays an important sex-specific role in skeletal muscle metabolism and whole body energy homeostasis.
Title: Skeletal muscle AMP-activated protein kinase γ1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity.
Data indicate that a diet high in iron improves glucose tolerance by activating AMPK through mechanisms that include deacetylation.
Title: Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice.
Results demonstrate that AMPKgamma1 subunit is required for the maintenance of erythrocyte membrane elasticity.
Title: The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia.
AMPK is not necessary for exercise training-induced increases in mitochondrial markers, but it is essential for fiber type IIb to IIa/x transformation and increases in hexokinase II protein[AMP-activated protein kinase gamma1]
Title: Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift.
In R70Qgamma1-expressing mice, there is an increase in muscle glycogen synthase activity associated with an increase in exercise capacity.
Title: Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484907

RH124519 (e-PCR)
- UniSTS:161341

NoName (e-PCR)
- UniSTS:548494

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables AMP binding	ISO Inferred from Sequence Orthology more info
contributes_to AMP-activated protein kinase activity	ISO Inferred from Sequence Orthology more info
enables AMP-activated protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of catalytic activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit gamma-1

Names: AMPK gamma1; AMPK subunit gamma-1; AMPKg

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411575.1 → NP_001398504.1 5'-AMP-activated protein kinase subunit gamma-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC161165
NM_016781.3 → NP_058061.2 5'-AMP-activated protein kinase subunit gamma-1 isoform 1

See identical proteins and their annotated locations for NP_058061.2

Status: VALIDATED

Source sequence(s)

AC161165

Consensus CDS

CCDS49724.1

UniProtKB/Swiss-Prot

O54950, Q5PRE8

UniProtKB/TrEMBL

Q3TWR3

Related

ENSMUSP00000132499.2, ENSMUST00000168846.3

Conserved Domains (2) summary

cd04618
Location:45 → 174

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:201 → 320

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...