Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkab1provided by MGI
Official Full Name: protein kinase, AMP-activated, beta 1 non-catalytic subunitprovided by MGI
Primary source: MGI:MGI:1336167
See related: Ensembl:ENSMUSG00000029513 AllianceGenome:MGI:1336167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E430008F22; 1300015D22Rik
Summary: Predicted to enable protein kinase activity and protein kinase binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within nail development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 43.6), liver E14.5 (RPKM 39.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.1 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (116151654..116162449, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (116013586..116024503, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Three-Dimensional Matrix Stiffness Activates the Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic Differentiation.
Title: Three-Dimensional Matrix Stiffness Activates the Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic Differentiation.
Blocking AMPK beta1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.
Title: Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.
Salsalate reduces atherosclerosis through AMPKbeta1 in mice.
Title: Salsalate reduces atherosclerosis through AMPKβ1 in mice.
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta1 isoforms.
Title: Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.
the evidence indicates that AMPK is sufficient but not essential for the maintenance of DAPC expression in skeletal muscle, yet it is required for preserving extrasynaptic utrophin levels in slow oxidative muscles.
Title: The role of AMP-activated protein kinase in the expression of the dystrophin-associated protein complex in skeletal muscle.
activation of AMPK at early stage of adipogenesis is involved in the anti-adipogenesis effect of Red Pepper Seed extract.
Title: Red Pepper Seed Inhibits Differentiation of 3T3-L1 Cells during the Early Phase of Adipogenesis via the Activation of AMPK.
in the absence of the tumor suppressor p53, germline genetic deletion of AMPK beta1 accelerates the appearance of a T-cell lymphoma that reduces lifespan compared to p53 deficiency alone.
Title: AMPK β1 reduces tumor progression and improves survival in p53 null mice.
In lipid-laden macrophages, Ampk activation decreased cholesterol content (foam cell formation) and increased cholesterol efflux to HDL and apoA-I, effects that occurred in an Ampk beta1-dependent manner.
Title: Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.
Salicylate activates the AMP-activated protein kinase (AMPK) by binding at the A-769662 drug binding site on the AMPK beta1-subunit
Title: Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.
AMPK directly relaxes vascular smooth muscle cell by a decrease of [Ca(2+)]i. This is achieved by calcium sequestration via SERCA activation, as well as activation of BKCa channels.
Title: AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (7) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136452 (e-PCR)
- UniSTS:210438

RH127243 (e-PCR)
- UniSTS:207857

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nail development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit beta-1

Names: AMPK subunit beta-1; AMPKb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417558.1 → NP_001404487.1 5'-AMP-activated protein kinase subunit beta-1

Status: VALIDATED

Source sequence(s)

AC115795

UniProtKB/Swiss-Prot

Q91YN6, Q9R078

UniProtKB/TrEMBL

Q542K0

Related

ENSMUSP00000107630.2, ENSMUST00000111999.8
NM_031869.3 → NP_114075.1 5'-AMP-activated protein kinase subunit beta-1

See identical proteins and their annotated locations for NP_114075.1

Status: VALIDATED

Source sequence(s)

AC115795

Consensus CDS

CCDS19598.1

UniProtKB/Swiss-Prot

Q91YN6, Q9R078

UniProtKB/TrEMBL

Q3U5I9, Q542K0

Related

ENSMUSP00000031486.8, ENSMUST00000031486.14

Conserved Domains (2) summary

smart01010
Location:181 → 270

AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain

pfam16561
Location:78 → 159

AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase