Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp2cbprovided by MGI
Official Full Name: protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformprovided by MGI
Primary source: MGI:MGI:1321161
See related: Ensembl:ENSMUSG00000009630 AllianceGenome:MGI:1321161
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP2Ac; D8Ertd766e
Summary: Predicted to enable protein C-terminus binding activity and protein serine/threonine phosphatase activity. Acts upstream of or within several processes, including apoptotic mitochondrial changes; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to hydrogen peroxide. Located in cytoplasm. Part of protein phosphatase type 2A complex. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; gut; and nervous system. Orthologous to human PPP2CB (protein phosphatase 2 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 44.0), testis adult (RPKM 44.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 20.63 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (34089672..34109831)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (33599621..33619804)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein phosphatase 2A catalytic subunit beta suppresses PMA/ionomycin-induced T-cell activation by negatively regulating PI3K/Akt signaling.
Title: Protein phosphatase 2A catalytic subunit β suppresses PMA/ionomycin-induced T-cell activation by negatively regulating PI3K/Akt signaling.
RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cbeta to deactivate IRF3.
Title: RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cβ to deactivate IRF3.
This study demonstrated that M. bovis infection increased PP2Ac expression in murine macrophages, while nilotinib a tyrosine kinase inhibitor (TKI) significantly suppressed PP2Ac expression.
Title: PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis-Infected Macrophages.
PP2B-Abeta limits platelet response to vascular injury by suppressing outside-in alphaII b beta3 integrin signaling
Title: The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling.
TRPV1 activation in endothelial cells may elicit a Ca(2+) -dependent effect on PP2B-PKC signalling, which leads to dephosphorylation of eNOS
Title: Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C.
PP2A activation via rapid, non-nuclear ER signaling may be a novel target for therapeutic approaches to inhibit vascular smooth muscle proliferation, which plays a central role in atherosclerosis and restenosis.
Title: Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation.
This study provides evidence that CaBP4 is dephosphorylated by PP2A in the retina.
Title: Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.
generated conditional null alleles of Ppp2ca and Ppp2cb by flanking with loxP sites exons 3 to 5 of Ppp2ca and exon 3 of Ppp2cb. Ppp2ca(fl/fl) mice did not display any visible phenotype
Title: Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
PP2A/C provides a dual inhibitory effect on Bcl2's survival function by both dephosphorylating Bcl2 and enhancing p53-Bcl2 binding.
Title: Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppp2cb (e-PCR), detects polymorphism
- UniSTS:526872

Ppp2cb (e-PCR), detects polymorphism
- UniSTS:526873

UniSTS:235869 (e-PCR)
- UniSTS:235869

D8Ertd766e (e-PCR), detects polymorphism
- UniSTS:167593

RH135869 (e-PCR)
- UniSTS:209867

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic mitochondrial changes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to antibiotic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lead ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Names: PP2A-beta

NP_001411800.1

EC 3.1.3.16

NP_059070.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424871.1 → NP_001411800.1 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform 2

Status: VALIDATED

Source sequence(s)

AC139025
NM_017374.4 → NP_059070.1 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform 1

See identical proteins and their annotated locations for NP_059070.1

Status: VALIDATED

Source sequence(s)

AC139025

Consensus CDS

CCDS22233.1

UniProtKB/Swiss-Prot

P62715

UniProtKB/TrEMBL

Q8BN07

Related

ENSMUSP00000009774.10, ENSMUST00000009774.11

Conserved Domains (1) summary

cd07415
Location:9 → 293

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain