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Ppp1cb protein phosphatase 1 catalytic subunit beta [ Mus musculus (house mouse) ]

Gene ID: 19046, updated on 11-Apr-2024

Summary

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Official Symbol
Ppp1cbprovided by MGI
Official Full Name
protein phosphatase 1 catalytic subunit betaprovided by MGI
Primary source
MGI:MGI:104871
See related
Ensembl:ENSMUSG00000014956 AllianceGenome:MGI:104871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200010B19
Summary
Enables protein serine/threonine phosphatase activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and protein dephosphorylation. Located in cytoplasm. Is expressed in cornea; lens epithelium; lens fiber; limb; and retina. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 116.5), liver E14 (RPKM 43.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 17.33 cM; 5 B1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32616192..32651057)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32458848..32493713)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phospholipase B1 Neighboring gene predicted gene, 36840 Neighboring gene STARR-seq mESC enhancer starr_12791 Neighboring gene STARR-seq mESC enhancer starr_12792 Neighboring gene STARR-seq mESC enhancer starr_12794 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12795 Neighboring gene predicted gene 15614 Neighboring gene STARR-seq mESC enhancer starr_12798 Neighboring gene methyltransferase-like protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12799 Neighboring gene STARR-positive B cell enhancer ABC_E8048 Neighboring gene predicted gene 10461 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1cβ, is essential for smooth muscle contraction. Chang AN, et al. J Biol Chem, 2018 Oct 26. PMID 30185619, Free PMC Article
  2. Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis. Cho YL, et al. Biochem Biophys Res Commun, 2015 Nov 13. PMID 26449462
  3. Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity. Gräff J, et al. Learn Mem, 2010 Jul. PMID 20592054
  4. Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. Garcia-Haro L, et al. FEBS Lett, 2012 Nov 30. PMID 23116618
  5. The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Ohkura H, et al. Cell, 1989 Jun 16. PMID 2544298

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Smooth muscle-specific conditional PP1cbeta knockout decreased contractile force development in bladder, ileal, and aortic tissues and reduced mouse survival.
    Title: The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1cβ, is essential for smooth muscle contraction.
  2. PPP1CB is a novel adipogenic activator that promotes adipogenesis in vivo and in vitro.
    Title: Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis.
  3. PP-1 is more abundant than PP-2A in the mouse eye; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-Balpha/beta/gamma are all differentially expressed.
    Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in glycogen granule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase PP1-beta catalytic subunit
Names
PP-1B
NP_766295.2
XP_006503843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172707.3 → NP_766295.2  serine/threonine-protein phosphatase PP1-beta catalytic subunit

    See identical proteins and their annotated locations for NP_766295.2

    Status: VALIDATED

    Source sequence(s)
    AC102372, AK017392, AK160743, AK166623
    Consensus CDS
    CCDS19193.1
    UniProtKB/Swiss-Prot
    P62141, Q3TBE5, Q3TL90, Q542E7, Q8C285, Q9DBY2
    UniProtKB/TrEMBL
    Q3U7K1
    Related
    ENSMUSP00000015100.9, ENSMUST00000015100.15
    Conserved Domains (1) summary
    cd07414
    Location:7 → 297
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    32616192..32651057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503780.2 → XP_006503843.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1

    Conserved Domains (1) summary
    cl13995
    Location:7 → 197
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62141.3 GenPept UniProtKB/Swiss-Prot:P62141

Gene LinkOut

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