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Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) [ Mus musculus (house mouse) ]

Gene ID: 18974, updated on 5-Mar-2024

Summary

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Official Symbol
Pole2provided by MGI
Official Full Name
polymerase (DNA directed), epsilon 2 (p59 subunit)provided by MGI
Primary source
MGI:MGI:1197514
See related
Ensembl:ENSMUSG00000020974 AllianceGenome:MGI:1197514
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA-dependent DNA replication and error-prone translesion synthesis. Predicted to act upstream of or within DNA replication. Predicted to be located in nuclear body. Predicted to be part of epsilon DNA polymerase complex. Is expressed in several structures, including limb mesenchyme; musculature; nervous system; respiratory system; and tongue. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 11.5), liver E14.5 (RPKM 10.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Pole2 in Genome Data Viewer
Location:
12 C2; 12 28.73 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69248547..69274979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69201773..69228205, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330151L19 gene Neighboring gene mannoside acetylglucosaminyltransferase 2 Neighboring gene dynein, axonemal assembly factor 2 Neighboring gene STARR-seq mESC enhancer starr_32361 Neighboring gene STARR-positive B cell enhancer ABC_E10753 Neighboring gene kelch domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32363 Neighboring gene kelch domain containing 2 Neighboring gene nuclear export mediator factor Neighboring gene STARR-seq mESC enhancer starr_32364 Neighboring gene STARR-positive B cell enhancer ABC_E10754

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon. Jokela M, et al. Nucleic Acids Res, 1998 Feb 1. PMID 9443964, Free PMC Article
  2. The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA. Wada M, et al. J Biochem, 2002 Mar. PMID 11872158
  3. Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Bellelli R, et al. Mol Cell, 2018 May 17. PMID 29754823, Free PMC Article
  4. Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. Zhou L, et al. FASEB J, 2017 Jan. PMID 27694478, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The second largest subunit of mouse DNA polymerase epsilon was found to interact with SAP18. The interaction induced repression of transcription.
    Title: The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of epsilon DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase epsilon subunit 2
Names
DNA polymerase II subunit 2
DNA polymerase epsilon small subunit
DNA polymerase epsilon subunit B
NP_035263.1
XP_006515661.1
XP_006515662.1
XP_011242320.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011133.2 → NP_035263.1  DNA polymerase epsilon subunit 2

    See identical proteins and their annotated locations for NP_035263.1

    Status: PROVISIONAL

    Source sequence(s)
    AF036898, AK077592
    Consensus CDS
    CCDS36463.1
    UniProtKB/Swiss-Prot
    O54956, Q6P3Y7, Q8BP72
    UniProtKB/TrEMBL
    Q3TA87
    Related
    ENSMUSP00000021359.6, ENSMUST00000021359.7
    Conserved Domains (2) summary
    pfam04042
    Location:288 → 489
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam12213
    Location:3 → 73
    Dpoe2NT; DNA polymerases epsilon N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69248547..69274979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244018.2 → XP_011242320.1  DNA polymerase epsilon subunit 2 isoform X1

    UniProtKB/TrEMBL
    Q3TA87
    Conserved Domains (1) summary
    pfam04042
    Location:228 → 429
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

  2. XM_006515599.1 → XP_006515662.1  DNA polymerase epsilon subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam04042
    Location:40 → 241
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

  3. XM_006515598.4 → XP_006515661.1  DNA polymerase epsilon subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VN66
    Conserved Domains (2) summary
    pfam12213
    Location:4 → 74
    Dpoe2NT; DNA polymerases epsilon N terminal
    cl13995
    Location:288 → 404
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54956.2 GenPept UniProtKB/Swiss-Prot:O54956

Gene LinkOut

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