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Plp1 proteolipid protein (myelin) 1 [ Mus musculus (house mouse) ]

Gene ID: 18823, updated on 21-Apr-2024

Summary

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Official Symbol
Plp1provided by MGI
Official Full Name
proteolipid protein (myelin) 1provided by MGI
Primary source
MGI:MGI:97623
See related
Ensembl:ENSMUSG00000031425 AllianceGenome:MGI:97623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
jp; Plp; msd; rsh; DM20; jimpy
Summary
Predicted to enable identical protein binding activity. Predicted to be a structural constituent of myelin sheath. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including cell maturation; long-chain fatty acid biosynthetic process; and neurogenesis. Located in myelin sheath. Is expressed in several structures, including alimentary system; cardiovascular system; musculature; nervous system; and sensory organ. Used to study Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 410.7), cortex adult (RPKM 272.7) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
X F1; X 59.1 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135720897..135739331)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136820148..136838582)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3262 Neighboring gene mortality factor 4 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E11056 Neighboring gene cDNA sequence BC065397 Neighboring gene glycine receptor, alpha 4 subunit Neighboring gene predicted gene, 54085 Neighboring gene STARR-seq mESC enhancer starr_47979 Neighboring gene RAB9B, member RAS oncogene family Neighboring gene predicted gene 15026

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse. Woods C, et al. Am J Physiol Gastrointest Liver Physiol, 2023 Feb 1. PMID 36511517
  2. TRPV2: A Key Player in Myelination Disorders of the Central Nervous System. Enrich-Bengoa J, et al. Int J Mol Sci, 2022 Mar 25. PMID 35408977, Free PMC Article
  3. Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia. Trevisiol A, et al. PLoS Biol, 2020 Nov. PMID 33196637, Free PMC Article
  4. Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease. Elitt MS, et al. Nature, 2020 Sep. PMID 32610343, Free PMC Article
  5. Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons. Lüders KA, et al. Glia, 2019 Apr. PMID 30637801

See all (472) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microglia-mediated demyelination protects against CD8[+] T cell-driven axon degeneration in mice carrying PLP defects.
    Title: Microglia-mediated demyelination protects against CD8(+) T cell-driven axon degeneration in mice carrying PLP defects.
  2. Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.
    Title: Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.
  3. Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag.
    Title: Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag.
  4. Identifying oligodendrocyte enhancers governing Plp1 expression.
    Title: Identifying oligodendrocyte enhancers governing Plp1 expression.
  5. Identity and lineage fate of proteolipid protein 1 gene (Plp1)-expressing cells in the embryonic murine spinal cord.
    Title: Identity and lineage fate of proteolipid protein 1 gene (Plp1)-expressing cells in the embryonic murine spinal cord.
  6. Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease.
    Title: Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease.
  7. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.
    Title: Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone.
  8. This report the mouse model in which maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons.
    Title: Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons.
  9. These results suggest that colitis promotes rapid enteric neurogenesis in adult mice and humans through differentiation of Sox2- and PLP1-expressing cells, which represent enteric glia and/or neural progenitors
    Title: Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells.
  10. This study demonstrated that Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.
    Title: Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of myelin sheath ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in AMPA selective glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within astrocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axon development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within axon ensheathment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system myelination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myelination IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myelination TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of integrin alphav-beta3 complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in myelin sheath HDA PubMed 
is_active_in myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myelin proteolipid protein
Names
lipophilin
myelin synthesis deficiency
rump shaker

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290561.2 → NP_001277490.1  myelin proteolipid protein isoform 2

    See identical proteins and their annotated locations for NP_001277490.1

    Status: VALIDATED

    Source sequence(s)
    AK160872, AL672008, BC027010
    Consensus CDS
    CCDS72436.1
    UniProtKB/Swiss-Prot
    P60202
    UniProtKB/TrEMBL
    Q3UYM8
    Related
    ENSMUSP00000108708.2, ENSMUST00000113085.2
    Conserved Domains (1) summary
    pfam01275
    Location:5 → 238
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  2. NM_001359117.1 → NP_001346046.1  myelin proteolipid protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671887, AL672008
    Consensus CDS
    CCDS30424.1
    UniProtKB/Swiss-Prot
    P60202, Q9WUS9
    UniProtKB/TrEMBL
    Q3UYM8
    Conserved Domains (1) summary
    pfam01275
    Location:5 → 273
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  3. NM_001359118.1 → NP_001346047.1  myelin proteolipid protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671887, AL672008
    Consensus CDS
    CCDS72436.1
    Conserved Domains (1) summary
    pfam01275
    Location:5 → 238
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  4. NM_001359119.1 → NP_001346048.1  myelin proteolipid protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671887, AL672008
    Consensus CDS
    CCDS30424.1
    UniProtKB/Swiss-Prot
    P60202, Q9WUS9
    UniProtKB/TrEMBL
    Q3UYM8
    Conserved Domains (1) summary
    pfam01275
    Location:5 → 273
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  5. NM_001359120.1 → NP_001346049.1  myelin proteolipid protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671887, AL672008
    Consensus CDS
    CCDS30424.1
    UniProtKB/Swiss-Prot
    P60202, Q9WUS9
    UniProtKB/TrEMBL
    Q3UYM8
    Conserved Domains (1) summary
    pfam01275
    Location:5 → 273
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  6. NM_011123.4 → NP_035253.1  myelin proteolipid protein isoform 1

    See identical proteins and their annotated locations for NP_035253.1

    Status: VALIDATED

    Source sequence(s)
    AK160872, AL672008, BC027010
    Consensus CDS
    CCDS30424.1
    UniProtKB/Swiss-Prot
    P60202, Q9WUS9
    UniProtKB/TrEMBL
    Q3UYM8
    Related
    ENSMUSP00000033800.7, ENSMUST00000033800.13
    Conserved Domains (1) summary
    pfam01275
    Location:5 → 273
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    135720897..135739331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001290562.1: Suppressed sequence

    Description
    NM_001290562.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60202.2 GenPept UniProtKB/Swiss-Prot:P60202

Gene LinkOut

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