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Phkg1 phosphorylase kinase gamma 1 [ Mus musculus (house mouse) ]

Gene ID: 18682, updated on 11-Apr-2024

Summary

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Official Symbol
Phkg1provided by MGI
Official Full Name
phosphorylase kinase gamma 1provided by MGI
Primary source
MGI:MGI:97579
See related
Ensembl:ENSMUSG00000025537 AllianceGenome:MGI:97579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phkg
Summary
Predicted to enable ATP binding activity; enzyme binding activity; and phosphorylase kinase activity. Predicted to be involved in glycogen metabolic process and protein phosphorylation. Predicted to act upstream of or within carbohydrate metabolic process and phosphorylation. Predicted to be part of phosphorylase kinase complex. Orthologous to human PHKG1 (phosphorylase kinase catalytic subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 14.4), heart adult (RPKM 12.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Phkg1 in Genome Data Viewer
Location:
5 G1.3; 5 68.26 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129892272..129907953, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129863431..129879134, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene predicted gene, 23245 Neighboring gene STARR-positive B cell enhancer ABC_E3624 Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E125 Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A B2 repeat insertion generates alternate structures of the mouse muscle gamma-phosphorylase kinase gene. Maichele AJ, et al. Genomics, 1993 Apr. PMID 8486349
  2. Two exons encode the calmodulin-binding domain in the mouse phosphorylase kinase catalytic subunit gene. Bender PK, et al. Genet Anal Tech Appl, 1993 Jun-Aug. PMID 8110484
  3. Skeletal muscle phosphorylase kinase catalytic subunit mRNAs are expressed in heart tissue but not in liver. Bender PK, et al. J Biol Chem, 1987 Jun 25. PMID 3597394
  4. Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology. Amemiya T, et al. NPJ Syst Biol Appl, 2015. PMID 28725458, Free PMC Article
  5. Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice. Chamberlain JS, et al. Proc Natl Acad Sci U S A, 1987 May. PMID 3472241, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorylase kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphorylase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of phosphorylase kinase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Names
phosphorylase kinase subunit gamma-1
serine/threonine-protein kinase PHKG1
NP_035209.1
XP_011239173.1
XP_036020769.1
XP_036020770.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011079.3 → NP_035209.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

    See identical proteins and their annotated locations for NP_035209.1

    Status: VALIDATED

    Source sequence(s)
    AC242408, BC055102
    Consensus CDS
    CCDS19701.1
    UniProtKB/Swiss-Prot
    P07934
    Related
    ENSMUSP00000026617.7, ENSMUST00000026617.13
    Conserved Domains (1) summary
    cl21453
    Location:16 → 291
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_145486.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC242408

  2. NR_145487.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC242408

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129892272..129907953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240871.4 → XP_011239173.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 185
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036164876.1 → XP_036020769.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 185
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036164877.1 → XP_036020770.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 185
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07934.3 GenPept UniProtKB/Swiss-Prot:P07934

Gene LinkOut

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