U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pdha2 pyruvate dehydrogenase E1 alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 18598, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pdha2provided by MGI
Official Full Name
pyruvate dehydrogenase E1 alpha 2provided by MGI
Primary source
MGI:MGI:97533
See related
Ensembl:ENSMUSG00000047674 AllianceGenome:MGI:97533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdhal
Summary
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in nervous system and testis. Orthologous to human PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 H1; 3 65.3 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (140915765..140918116, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (141210004..141212355, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09142 Neighboring gene RIKEN cDNA 4930590L14 gene Neighboring gene predicted gene, 32754 Neighboring gene STARR-seq mESC enhancer starr_09143 Neighboring gene predicted gene, 32875 Neighboring gene STARR-seq mESC enhancer starr_09144 Neighboring gene STARR-seq mESC enhancer starr_09145 Neighboring gene unc-5 netrin receptor C Neighboring gene predicted gene 15689 Neighboring gene STARR-seq mESC enhancer starr_09146 Neighboring gene STARR-seq mESC enhancer starr_09149 Neighboring gene STARR-seq mESC enhancer starr_09150 Neighboring gene bone morphogenetic protein receptor, type 1B Neighboring gene STARR-seq mESC enhancer starr_09151

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Temporal and tissue-specific interactions involving novel transcription factors and the proximal promoter of the mouse Pdha-2 gene. Iannello RC, et al. J Biol Chem, 1993 Oct 25. PMID 7693672
  2. Transcriptional expression of a testis-specific variant of the mouse pyruvate dehydrogenase E1 alpha subunit. Iannello RC, et al. Biol Reprod, 1992 Jul. PMID 1637947
  3. The expression pattern of the pyruvate dehydrogenase E1 alpha subunit genes during spermatogenesis in adult mouse. Takakubo F, et al. Exp Cell Res, 1992 Mar. PMID 1735460
  4. Pyruvate dehydrogenase E1 alpha subunit genes in the mouse: mapping and comparison with human homologs. Brown RM, et al. Somat Cell Mol Genet, 1990 Sep. PMID 2122529
  5. Isolation and characterisation of the mouse pyruvate dehydrogenase E1 alpha genes. Fitzgerald J, et al. Biochim Biophys Acta, 1992 May 7. PMID 1581363

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
contributes_to pyruvate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
  
involved_in acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Names
PDHE1-A type II
PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT, TESTIS-SPECIFIC FORM, MITOCHONDRIAL PRECURSOR (PDHE1-A TYPE II)
NP_032837.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008811.2 → NP_032837.1  pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032837.1

    Status: VALIDATED

    Source sequence(s)
    AC100752
    Consensus CDS
    CCDS17872.1
    UniProtKB/Swiss-Prot
    P35487, Q497M8
    UniProtKB/TrEMBL
    Q9D9X9
    Related
    ENSMUSP00000060774.3, ENSMUST00000057860.3
    Conserved Domains (1) summary
    TIGR03182
    Location:59 → 371
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    140915765..140918116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35487.1 GenPept UniProtKB/Swiss-Prot:P35487

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous