Pdgfra platelet derived growth factor receptor, alpha polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdgfraprovided by MGI
Official Full Name: platelet derived growth factor receptor, alpha polypeptideprovided by MGI
Primary source: MGI:MGI:97530
See related: Ensembl:ENSMUSG00000029231 AllianceGenome:MGI:97530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD140a; Pdgfr-2
Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]
Expression: Broad expression in limb E14.5 (RPKM 29.6), lung adult (RPKM 20.2) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 39.55 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (75311988..75358867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (75151322..75198206)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling.
Title: Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling.
Myeloid Cell-Specific Deletion of PDGFR-alpha Promotes Dysbiotic Intestinal Microbiota and thus Increased Colitis Susceptibility.
Title: Myeloid Cell-Specific Deletion of PDGFR-α Promotes Dysbiotic Intestinal Microbiota and thus Increased Colitis Susceptibility.
ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination by Cleaving NG2 Proteoglycan and Attenuating PDGFRalpha Signaling.
Title: ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination by Cleaving NG2 Proteoglycan and Attenuating PDGFRα Signaling.
PDGF receptor signal mediates the contribution of Nestin-positive cell lineage to subcutaneous fat development.
Title: PDGF receptor signal mediates the contribution of Nestin-positive cell lineage to subcutaneous fat development.
Temporal control of PDGFRalpha regulates the fibroblast-to-myofibroblast transition in wound healing.
Title: Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing.
Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRalpha signalling in cerebellar development.
Title: Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development.
PDGFRalpha-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms.
Title: PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms.
Platelet-Derived Growth Factor Receptor Type alpha Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension.
Title: Platelet-Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension.
PDGF-AA promotes cell-to-cell communication in osteocytes through PI3K/Akt signaling pathway.
Title: PDGF-AA promotes cell-to-cell communication in osteocytes through PI3K/Akt signaling pathway.
PDGFRalpha-lineage origin directs monocytes to trafficking proficiency to support peripheral immunity.
Title: PDGFRα-lineage origin directs monocytes to trafficking proficiency to support peripheral immunity.

Submit: New GeneRIF Correction See all GeneRIFs (151)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (27) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pdgfra (e-PCR), detects polymorphism
- UniSTS:526091

Pdgfra (e-PCR), detects polymorphism
- UniSTS:144153

D5Mit201 (e-PCR), detects polymorphism
- UniSTS:130332

Pdgfra (e-PCR), detects polymorphism
- UniSTS:464686

NoName (e-PCR)
- UniSTS:548151

M84607 (e-PCR)
- UniSTS:124992

D5Mit235 (e-PCR), detects polymorphism
- UniSTS:130369

PMC317149P1 (e-PCR)
- UniSTS:273076

RH135893 (e-PCR)
- UniSTS:209891

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor alpha-receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor alpha-receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables platelet-derived growth factor alpha-receptor activity	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables platelet-derived growth factor binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor binding	TAS Traceable Author Statement more info	PubMed
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Leydig cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adrenal gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anatomical structure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac myofibril assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in embryonic cranial skeleton morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within estrogen metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female gonad development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within luteinization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within luteinization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric glomerular capillary formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in retina vasculature development in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction involved in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: platelet-derived growth factor receptor alpha

Names: Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); CD140 antigen-like family member A; PDGF alpha chain; PDGF-R-alpha; PDGFR-alpha; alpha-type platelet-derived growth factor receptor

NP_001076785.1

EC 2.7.10.1

NP_001334647.1

EC 2.7.10.1

NP_001334648.1

EC 2.7.10.1

NP_035188.2

EC 2.7.10.1

XP_006504324.1

EC 2.7.10.1

XP_006504325.1

EC 2.7.10.1

XP_006504326.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083316.2 → NP_001076785.1 platelet-derived growth factor receptor alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_001076785.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK147267, BC053036, BY628767, CD354225, CK627326

Consensus CDS

CCDS19351.1

UniProtKB/Swiss-Prot

P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3

Related

ENSMUSP00000127173.2, ENSMUST00000168162.5

Conserved Domains (5) summary

cd04972
Location:416 → 497

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05859
Location:313 → 413

Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)

cd05861
Location:228 → 311

Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)

cd05105
Location:555 → 956

PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha

pfam13927
Location:28 → 100

Ig_3; Immunoglobulin domain
NM_001347718.1 → NP_001334647.1 platelet-derived growth factor receptor alpha isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 1, which results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as 'In-PDGFRalpha') is shorter and has a distinct C-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).

Source sequence(s)

AC120348, AK081664, AK147267

Consensus CDS

CCDS89929.1

UniProtKB/Swiss-Prot

P26618

Related

ENSMUSP00000143906.2, ENSMUST00000202681.4
NM_001347719.1 → NP_001334648.1 platelet-derived growth factor receptor alpha isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 1, which results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as 'In-PDGFRalpha') is shorter and has a distinct C-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).

Source sequence(s)

AC120348, AK081664, AK147267

Consensus CDS

CCDS89929.1

UniProtKB/Swiss-Prot

P26618

Related

ENSMUSP00000143891.2, ENSMUST00000201711.4
NM_011058.3 → NP_035188.2 platelet-derived growth factor receptor alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_035188.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AC120348, AK147267, BY628767, CK627326

Consensus CDS

CCDS19351.1

UniProtKB/Swiss-Prot

P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3

Related

ENSMUSP00000000476.9, ENSMUST00000000476.15

Conserved Domains (5) summary

cd04972
Location:416 → 497

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05859
Location:313 → 413

Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)

cd05861
Location:228 → 311

Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)

cd05105
Location:555 → 956

PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha

pfam13927
Location:28 → 100

Ig_3; Immunoglobulin domain

RNA

NR_144636.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) includes a 3' terminal exon that extends past a splice site that is used in variant 1. This variant is represented as non-coding because it lacks a stop codon, rendering the transcript a candidate for non-stop decay.

Source sequence(s)

AC120348, AK139094, AK147267

Related

ENSMUST00000202186.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

75311988..75358867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504263.5 → XP_006504326.1 platelet-derived growth factor receptor alpha isoform X1

See identical proteins and their annotated locations for XP_006504326.1

UniProtKB/Swiss-Prot

P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3

Conserved Domains (5) summary

cd04972
Location:416 → 497

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05859
Location:313 → 413

Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)

cd05861
Location:228 → 311

Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)

cd05105
Location:555 → 956

PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha

pfam13927
Location:28 → 100

Ig_3; Immunoglobulin domain
XM_006504261.5 → XP_006504324.1 platelet-derived growth factor receptor alpha isoform X1

See identical proteins and their annotated locations for XP_006504324.1

UniProtKB/Swiss-Prot

P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3

Conserved Domains (5) summary

cd04972
Location:416 → 497

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05859
Location:313 → 413

Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)

cd05861
Location:228 → 311

Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)

cd05105
Location:555 → 956

PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha

pfam13927
Location:28 → 100

Ig_3; Immunoglobulin domain
XM_006504262.5 → XP_006504325.1 platelet-derived growth factor receptor alpha isoform X1

See identical proteins and their annotated locations for XP_006504325.1

UniProtKB/Swiss-Prot

P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3

Conserved Domains (5) summary

cd04972
Location:416 → 497

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05859
Location:313 → 413

Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)

cd05861
Location:228 → 311

Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)

cd05105
Location:555 → 956

PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha

pfam13927
Location:28 → 100

Ig_3; Immunoglobulin domain