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Furin furin, paired basic amino acid cleaving enzyme [ Mus musculus (house mouse) ]

Gene ID: 18550, updated on 21-Apr-2024

Summary

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Official Symbol
Furinprovided by MGI
Official Full Name
furin, paired basic amino acid cleaving enzymeprovided by MGI
Primary source
MGI:MGI:97513
See related
Ensembl:ENSMUSG00000030530 AllianceGenome:MGI:97513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fur; PACE; SPC1; Pcsk3; 9130404I01Rik
Summary
This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Broad expression in stomach adult (RPKM 243.5), adrenal adult (RPKM 89.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D2; 7 45.65 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80038942..80055188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80389194..80405441, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene HD domain containing 3 Neighboring gene mannosidase 2, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene feline sarcoma oncogene Neighboring gene predicted gene 44851 Neighboring gene serine hydroxymethyltransferase 2 pseudogene Neighboring gene VISTA enhancer mm169 Neighboring gene Bloom syndrome, RecQ like helicase Neighboring gene STARR-seq mESC enhancer starr_19328 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice. Ojanen MJT, et al. Eur J Immunol, 2023 Jun. PMID 37015057
  2. The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance. Liang Z, et al. iScience, 2022 Oct 21. PMID 36274943, Free PMC Article
  3. Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells. Ortutay Z, et al. Front Immunol, 2021. PMID 33679774, Free PMC Article
  4. Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction. Brouwers B, et al. Diabetes, 2021 Feb. PMID 33277337
  5. Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer. He Z, et al. Cancer Lett, 2020 Aug 1. PMID 32389711

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury.
    Title: Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury.
  2. FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice.
    Title: FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice.
  3. FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy.
    Title: FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy.
  4. Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
    Title: Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
  5. Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
    Title: Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
  6. In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
    Title: In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
  7. Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells.
    Title: Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells.
  8. Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic beta Cells of Mice.
    Title: Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice.
  9. Loss of Furin in beta-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to beta-Cell Dysfunction.
    Title: Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction.
  10. Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
    Title: Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity EXP
Inferred from Experiment
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity TAS
Traceable Author Statement
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in blastocyst formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytokine precursor processing ISO
Inferred from Sequence Orthology
more info
  
involved_in dibasic protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in nerve growth factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide hormone processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cholesterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in secretion by cell ISO
Inferred from Sequence Orthology
more info
  
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
  
involved_in zymogen activation ISO
Inferred from Sequence Orthology
more info
  
involved_in zymogen inhibition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome TAS
Traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in trans-Golgi network transport vesicle membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
furin
Names
dibasic-processing enzyme
paired basic amino acid residue cleaving enzyme
prohormone convertase 3
proprotein convertase subtilisin/kexin type 3
subtilisin pro-protein processing enzyme
NP_001074923.1
NP_035176.1
XP_011249120.1
XP_011249121.1
XP_011249122.1
XP_011249123.1
XP_011249124.1
XP_011249125.1
XP_030098069.1
XP_030098070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081454.2 → NP_001074923.1  furin preproprotein

    See identical proteins and their annotated locations for NP_001074923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC136740
    Consensus CDS
    CCDS21397.1
    UniProtKB/Swiss-Prot
    P23188, Q6GTN6
    Related
    ENSMUSP00000102985.4, ENSMUST00000107362.10
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  2. NM_011046.3 → NP_035176.1  furin preproprotein

    See identical proteins and their annotated locations for NP_035176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC136740
    Consensus CDS
    CCDS21397.1
    UniProtKB/Swiss-Prot
    P23188, Q6GTN6
    Related
    ENSMUSP00000113370.2, ENSMUST00000122232.8
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80038942..80055188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250821.3 → XP_011249123.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249123.1

    Conserved Domains (4) summary
    cd04059
    Location:113 → 412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648 → 685
    FU; Furin-like repeats
    pfam01483
    Location:494 → 580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  2. XM_011250822.3 → XP_011249124.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249124.1

    Conserved Domains (4) summary
    cd04059
    Location:113 → 412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648 → 685
    FU; Furin-like repeats
    pfam01483
    Location:494 → 580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  3. XM_011250819.4 → XP_011249121.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249121.1

    Conserved Domains (4) summary
    cd04059
    Location:113 → 412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648 → 685
    FU; Furin-like repeats
    pfam01483
    Location:494 → 580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  4. XM_011250818.2 → XP_011249120.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249120.1

    Conserved Domains (4) summary
    cd04059
    Location:113 → 412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648 → 685
    FU; Furin-like repeats
    pfam01483
    Location:494 → 580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  5. XM_030242209.2 → XP_030098069.1  furin isoform X2

    UniProtKB/Swiss-Prot
    P23188, Q6GTN6
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  6. XM_011250820.4 → XP_011249122.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249122.1

    Conserved Domains (4) summary
    cd04059
    Location:113 → 412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648 → 685
    FU; Furin-like repeats
    pfam01483
    Location:494 → 580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  7. XM_030242210.2 → XP_030098070.1  furin isoform X2

    UniProtKB/Swiss-Prot
    P23188, Q6GTN6
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  8. XM_011250823.1 → XP_011249125.1  furin isoform X1

    See identical proteins and their annotated locations for XP_011249125.1

    Conserved Domains (4) summary
    cd04059
    Location:113 → 412
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648 → 685
    FU; Furin-like repeats
    pfam01483
    Location:494 → 580
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23188.2 GenPept UniProtKB/Swiss-Prot:P23188

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