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Pax7 paired box 7 [ Mus musculus (house mouse) ]

Gene ID: 18509, updated on 21-Apr-2024

Summary

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Official Symbol
Pax7provided by MGI
Official Full Name
paired box 7provided by MGI
Primary source
MGI:MGI:97491
See related
Ensembl:ENSMUSG00000028736 AllianceGenome:MGI:97491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pax-7
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; sensory organ; and skeletal musculature. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 2.5), CNS E11.5 (RPKM 2.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 70.83 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139464357..139560841, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139737059..139833530, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene taste receptor, type 1, member 2 Neighboring gene predicted gene, 42334 Neighboring gene STARR-seq mESC enhancer starr_11839 Neighboring gene STARR-seq mESC enhancer starr_11840 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:139369700-139369901 Neighboring gene predicted gene, 46873 Neighboring gene STARR-seq mESC enhancer starr_11842 Neighboring gene RIKEN cDNA 4933427I22 gene Neighboring gene predicted gene 1667 Neighboring gene STARR-seq mESC enhancer starr_11844 Neighboring gene kelch domain containing 7A Neighboring gene microRNA 2139

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Melatonin improves muscle injury and differentiation by increasing Pax7 expression. Su CM, et al. Int J Biol Sci, 2023. PMID 36923937, Free PMC Article
  2. Pax7 pioneer factor action requires both paired and homeo DNA binding domains. Pelletier A, et al. Nucleic Acids Res, 2021 Jul 21. PMID 34197620, Free PMC Article
  3. Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice. Sincennes MC, et al. Nat Commun, 2021 May 31. PMID 34059674, Free PMC Article
  4. Epigenetic effects induced by the ectopic expression of Pax7 in 3T3-L1. Elgaabari A, et al. J Biochem, 2021 Sep 22. PMID 33729538
  5. Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas. Florkowska A, et al. Stem Cell Res Ther, 2020 Jun 17. PMID 32552916, Free PMC Article

See all (736) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-mobility group box-1 impedes skeletal muscle regeneration via downregulation of Pax-7 synthesis by increasing miR-342-5p expression.
    Title: High-mobility group box-1 impedes skeletal muscle regeneration via downregulation of Pax-7 synthesis by increasing miR-342-5p expression.
  2. Melatonin improves muscle injury and differentiation by increasing Pax7 expression.
    Title: Melatonin improves muscle injury and differentiation by increasing Pax7 expression.
  3. PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs.
    Title: PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs.
  4. Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity.
    Title: Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity.
  5. Epigenetic effects induced by the ectopic expression of Pax7 in 3T3-L1.
    Title: Epigenetic effects induced by the ectopic expression of Pax7 in 3T3-L1.
  6. Pax7 pioneer factor action requires both paired and homeo DNA binding domains.
    Title: Pax7 pioneer factor action requires both paired and homeo DNA binding domains.
  7. Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.
    Title: Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.
  8. Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice.
    Title: Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice.
  9. Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells.
    Title: Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells.
  10. Wnt/beta-catenin signaling induces the myomiRs miR-133b and miR-206 to suppress Pax7 and induce the myogenic differentiation program.
    Title: Wnt/β-catenin signaling induces the myomiRs miR-133b and miR-206 to suppress Pax7 and induce the myogenic differentiation program.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle tissue morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of myoblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of chromatin organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle satellite cell commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spinal cord association neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
paired box protein Pax-7
Names
paired box gene 7
paired box transcription factor PAX7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011039.3 → NP_035169.1  paired box protein Pax-7

    See identical proteins and their annotated locations for NP_035169.1

    Status: VALIDATED

    Source sequence(s)
    AL831790, AL844480
    Consensus CDS
    CCDS18850.1
    UniProtKB/Swiss-Prot
    P47239, Q9ES16
    Related
    ENSMUSP00000030508.7, ENSMUST00000030508.14
    Conserved Domains (3) summary
    smart00351
    Location:34 → 159
    PAX; Paired Box domain
    pfam00046
    Location:218 → 272
    Homeobox; Homeobox domain
    pfam12360
    Location:345 → 383
    Pax7; Paired box protein 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    139464357..139560841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538630.2 → XP_006538693.1  paired box protein Pax-7 isoform X2

    Conserved Domains (3) summary
    smart00351
    Location:34 → 160
    PAX; Paired Box domain
    pfam00046
    Location:219 → 273
    Homeobox; Homeobox domain
    pfam12360
    Location:346 → 384
    Pax7; Paired box protein 7

  2. XM_006538629.2 → XP_006538692.1  paired box protein Pax-7 isoform X1

    UniProtKB/TrEMBL
    G3UX36
    Related
    ENSMUSP00000133536.2, ENSMUST00000174681.2
    Conserved Domains (3) summary
    smart00351
    Location:34 → 161
    PAX; Paired Box domain
    pfam00046
    Location:220 → 274
    Homeobox; Homeobox domain
    pfam12360
    Location:347 → 385
    Pax7; Paired box protein 7

  3. XM_006538631.2 → XP_006538694.1  paired box protein Pax-7 isoform X3

    Conserved Domains (3) summary
    smart00351
    Location:34 → 158
    PAX; Paired Box domain
    pfam00046
    Location:217 → 271
    Homeobox; Homeobox domain
    pfam12360
    Location:344 → 382
    Pax7; Paired box protein 7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47239.2 GenPept UniProtKB/Swiss-Prot:P47239

Gene LinkOut

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