Mybbp1a MYB binding protein (P160) 1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mybbp1aprovided by MGI
Official Full Name: MYB binding protein (P160) 1aprovided by MGI
Primary source: MGI:MGI:106181
See related: Ensembl:ENSMUSG00000040463 AllianceGenome:MGI:106181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P160; p67MBP; p160MBP
Summary: Enables E-box binding activity and transcription corepressor activity. Involved in circadian regulation of gene expression and negative regulation of transcription, DNA-templated. Acts upstream of or within respiratory electron transport chain. Located in cytoplasm and nucleolus. Part of NLS-dependent protein nuclear import complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and limb. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 38.4), ovary adult (RPKM 36.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 44.29 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72332153..72342596)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (72441327..72451770)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.
Title: In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.
Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer.
Title: Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer.
Mybbp1a is a novel negative regulator of Sirt7.
Title: Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a).
Data show that down-regulation of MYBBP1A decreases the growth rate of wild type mouse embryonic stem cells, embryo fibroblasts (MEFs) and of human HeLa cells, where it also promotes apoptosis.
Title: Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor.
Mybbp1a may play a dual role in the rRNA metabolism, potentially linking and coordinating ribosomal DNA transcription and pre-rRNA processing to allow for the efficient synthesis of ribosomes.
Title: Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.
Myb-binding protein 1a was identified as a novel negative regulator of muscle-specific gene expression and myoblast differentiation.
Title: Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.
Myb-binding protein p160 is a novel target of the von Hippel-Lindau tumor suppressor.
Title: Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor.
Ipr1 might be involved in apoptosis pathway via MYBBP1A.
Title: MYBBP1A: a new Ipr1's binding protein in mice.
Results suggest that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
Title: Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
Mybbp1a may connect the ribosome biogenesis and the Myb-dependent transcription, which controls cell cycle progression and proliferation.
Title: Ribosomal stress induces processing of Mybbp1a and its translocation from the nucleolus to the nucleoplasm.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125539 (e-PCR)
- UniSTS:162354

NoName (e-PCR)
- UniSTS:236851

RH136313 (e-PCR)
- UniSTS:210305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription factor binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase I	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect regulation of G1 to G0 transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory electron transport chain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of B-WICH complex	ISO Inferred from Sequence Orthology more info
part_of NLS-dependent protein nuclear import complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myb-binding protein 1A

Names: myb-binding protein of 160 kDa; nuclear protein P160

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016776.3 → NP_058056.2 myb-binding protein 1A

See identical proteins and their annotated locations for NP_058056.2

Status: VALIDATED

Source sequence(s)

BC048858, CJ305435, CN716759

Consensus CDS

CCDS24986.1

UniProtKB/Swiss-Prot

O35851, Q7TPV4, Q80Y66, Q8R4X2, Q99KP0

UniProtKB/TrEMBL

A0JLT5, Q3U2W2

Related

ENSMUSP00000044827.6, ENSMUST00000045633.6

Conserved Domains (3) summary

pfam04931
Location:70 → 835

DNA_pol_phi; DNA polymerase phi

pfam05104
Location:1143 → 1289

Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

pfam15304
Location:1193 → 1340

AKAP2_C; A-kinase anchor protein 2 C-terminus