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Oprd1 opioid receptor, delta 1 [ Mus musculus (house mouse) ]

Gene ID: 18386, updated on 21-Apr-2024

Summary

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Official Symbol
Oprd1provided by MGI
Official Full Name
opioid receptor, delta 1provided by MGI
Primary source
MGI:MGI:97438
See related
Ensembl:ENSMUSG00000050511 AllianceGenome:MGI:97438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DOR; Nbor; mDOR; DOR-1
Summary
Enables G protein-coupled opioid receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adult locomotory behavior; and neuropeptide signaling pathway. Located in membrane. Is integral component of membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and neural retina. Orthologous to human OPRD1 (opioid receptor delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 3.5), cortex adult (RPKM 2.6) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 64.78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131834980..131872042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132110188..132144486, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1 Neighboring gene VISTA enhancer mm1387 Neighboring gene STARR-positive B cell enhancer ABC_E4674 Neighboring gene predicted gene, 36157 Neighboring gene VISTA enhancer mm80 Neighboring gene STARR-positive B cell enhancer ABC_E3518 Neighboring gene STARR-seq mESC enhancer starr_11553 Neighboring gene STARR-seq mESC enhancer starr_11554 Neighboring gene nuclear encoded tRNA alanine 3 (anticodon CGC) Neighboring gene STARR-seq mESC enhancer starr_11556 Neighboring gene predicted gene 13215 Neighboring gene STARR-seq mESC enhancer starr_11557 Neighboring gene YTH N6-methyladenosine RNA binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Delta Opioid Receptor in Astrocytes Contributes to Neuropathic Cold Pain and Analgesic Tolerance in Female Mice. Reiss D, et al. Front Cell Neurosci, 2021. PMID 34602984, Free PMC Article
  2. Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain. Zhou W, et al. J Biol Chem, 2021 Jan-Jun. PMID 33428940, Free PMC Article
  3. Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia. Dripps IJ, et al. Sci Rep, 2020 Oct 19. PMID 33077757, Free PMC Article
  4. Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain. Jimenez-Vargas NN, et al. Proc Natl Acad Sci U S A, 2020 Jun 30. PMID 32546520, Free PMC Article
  5. In vivo mapping of a GPCR interactome using knockin mice. Degrandmaison J, et al. Proc Natl Acad Sci U S A, 2020 Jun 9. PMID 32457152, Free PMC Article

See all (189) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early-life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through upregulation of delta opioid receptors in mice.
    Title: Early-life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through upregulation of δ opioid receptors in mice.
  2. Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
    Title: Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
  3. Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis.
    Title: Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis.
  4. A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.
    Title: A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.
  5. Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons.
    Title: Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons.
  6. Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.
    Title: Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.
  7. Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain.
    Title: Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain.
  8. Basolateral Amygdala Drives a GPCR-Mediated Striatal Memory Necessary for Predictive Learning to Influence Choice.
    Title: Basolateral Amygdala Drives a GPCR-Mediated Striatal Memory Necessary for Predictive Learning to Influence Choice.
  9. Delta-Opioid Receptor gene is transcriptionally more diverse than previously demonstrated, producing novel protein isoforms in humans and mice.
    Title: Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms.
  10. DOR-MOR co-expression is limited to excitatory interneurons in the spinal cord dorsal horn and ventral horn motor circuits and regulates mechanical pain.
    Title: Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
Submit: New GeneRIF Correction See all GeneRIFs (76)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled enkephalin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled enkephalin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled opioid receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled opioid receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled opioid receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal dense core vesicle EXP
Inferred from Experiment
more info
 PubMed 
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in spine apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
delta-type opioid receptor
Names
D-OR-1
K56
MSL-2
delta 1 opioid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013622.3 → NP_038650.3  delta-type opioid receptor

    See identical proteins and their annotated locations for NP_038650.3

    Status: VALIDATED

    Source sequence(s)
    AK043873, L06322
    Consensus CDS
    CCDS18718.1
    UniProtKB/Swiss-Prot
    P32300
    UniProtKB/TrEMBL
    A2AD37, Q8BLP9
    Related
    ENSMUSP00000050077.2, ENSMUST00000056336.2
    Conserved Domains (2) summary
    pfam00001
    Location:66 → 318
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:59 → 232
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    131834980..131872042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538628.5 → XP_006538691.1  delta-type opioid receptor isoform X1

    UniProtKB/TrEMBL
    B1ACW5
    Conserved Domains (2) summary
    cd14964
    Location:35 → 61
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:27 → 280
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32300.1 GenPept UniProtKB/Swiss-Prot:P32300

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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