Oit3 oncoprotein induced transcript 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oit3provided by MGI
Official Full Name: oncoprotein induced transcript 3provided by MGI
Primary source: MGI:MGI:1201782
See related: Ensembl:ENSMUSG00000009654 AllianceGenome:MGI:1201782
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LZP; EF-9
Summary: Predicted to be an extracellular matrix structural constituent. Acts upstream of or within urate homeostasis. Predicted to be located in nucleus. Predicted to be active in cell surface and extracellular space. Is expressed in embryo and liver. Orthologous to human OIT3 (oncoprotein induced transcript 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 16.9), liver E14.5 (RPKM 11.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 29.54 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (59258782..59277601, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (59422960..59441779, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability.
Title: LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability.
Data suggest that OIT3 could maintain urate homeostasis by regulating the excretion and reabsorption of uric acid in renal tubule via cooperating with THP.
Title: OIT3 deficiency impairs uric acid reabsorption in renal tubule.
The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens.
Title: Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules.
mouse LZP localizes mostly on nuclear envelope, and at the same time, it can be secreted into blood in a truncated form.
Title: Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within renal system process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oncoprotein-induced transcript 3 protein

Names: liver-specific zona pellucida domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010959.2 → NP_035089.1 oncoprotein-induced transcript 3 protein precursor

See identical proteins and their annotated locations for NP_035089.1

Status: PROVISIONAL

Source sequence(s)

AK040570

Consensus CDS

CCDS23865.1

UniProtKB/Swiss-Prot

P97806, Q811T0, Q8C9U1, Q8R4V5

Related

ENSMUSP00000009798.5, ENSMUST00000009798.5

Conserved Domains (3) summary

smart00241
Location:268 → 513

ZP; Zona pellucida (ZP) domain

pfam00100
Location:394 → 513

Zona_pellucida; Zona pellucida-like domain

pfam14670
Location:227 → 262

FXa_inhibition; Coagulation Factor Xa inhibitory site