Ogn osteoglycin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ognprovided by MGI
Official Full Name: osteoglycinprovided by MGI
Primary source: MGI:MGI:109278
See related: Ensembl:ENSMUSG00000021390 AllianceGenome:MGI:109278
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OG; OIF; SLRR3A; mimecan; mimican; 3110079A16Rik
Summary: Predicted to enable growth factor activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Predicted to be involved in negative regulation of smooth muscle cell proliferation. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and skeleton. Orthologous to human OGN (osteoglycin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 41.4), limb E14.5 (RPKM 40.9) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 25.34 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49761491..49777977)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49608015..49624501)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Age-dependent mechanical properties of tail tendons in wild-type and mimecan gene-knockout mice - A preliminary study.
Title: Age-dependent mechanical properties of tail tendons in wild-type and mimecan gene-knockout mice - A preliminary study.
Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial-mesenchymal transformation in a mouse model of myocarditis.
Title: Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial-mesenchymal transformation in a mouse model of myocarditis.
Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin.
Title: Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin.
Osteoglycin negatively regulates cardiac fibrotic remodelling by attenuating myofibroblast proliferation and migration through LPA3-mediated and Rho/ROCK-dependent inhibition of MT1-MMP translocation, MMP2 activation and EGFR transactivation.
Title: Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling.
NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin.
Title: Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
These results reveal a novel pathway in which miR-155 inhibits Ogn expression to regulate proliferation and differentiation of C2C12 myoblast cells.
Title: Osteoglycin inhibition by microRNA miR-155 impairs myogenesis.
elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1).
Title: C/EBPβ LIP augments cell death by inducing osteoglycin.
OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration.
Title: Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway.
The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4.
Title: A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis.
mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1beta and IL-6 expression in the hypothalamus.
Title: Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D31951 (e-PCR)
- UniSTS:160298

D31951 (e-PCR)
- UniSTS:124824

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring compression resistance	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in articular cartilage development	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed

General protein information

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Preferred Names: mimecan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008760.5 → NP_032786.1 mimecan precursor

See identical proteins and their annotated locations for NP_032786.1

Status: VALIDATED

Source sequence(s)

AK160760, AK163772, BB630217, BE629408

Consensus CDS

CCDS26505.1

UniProtKB/Swiss-Prot

Q62000

UniProtKB/TrEMBL

Q543C5

Related

ENSMUSP00000021822.6, ENSMUST00000021822.7

Conserved Domains (4) summary

cd00116
Location:143 → 275

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:123 → 144

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:143 → 225

LRR_8; Leucine rich repeat

pfam15376
Location:61 → 158

DUF4603; Domain of unknown function (DUF4603)